Iodine concentration in different human brain parts

Andrási, Erzsébet; Bélavári, Cs.; Stibilj, Vekoslava; Dermelj, M.; Gawlik, D.

doi:10.1007/s00216-003-2313-3

Cited by 12 publications

(4 citation statements)

References 27 publications

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“…The nature and site of iodine binding in the human brain is still unknown. The results of Andrasi et al (Andrási et al, 2004) investigations on iodine distribution between the lipid fraction and in the brain tissue without lipid have indicated that its mean contents vary between 910 ± 147 ng/g dry weight and 281 ± 68 ng/g dry weight depending on the brain region (the highest content was found in susbstantia nigra and the lowest in vermis crebelli).…”

Section: Brainmentioning

confidence: 98%

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

Błażewicz¹

2012

Macro to Nano Spectroscopy

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Section: Brainmentioning

confidence: 98%

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

Błażewicz¹

2012

Macro to Nano Spectroscopy

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“…hyperintense on T1W and hypointense on T2W). These structures are very metabolically active and contain large amounts of iodine [83] and so may be more susceptible to insults caused by ID. Additionally, Alves et al [68] found hyperintense white matter in the anterior and posterior forceps, splenium and frontal lobes on T2W MRI.…”

Section: Location Of the Abnormalitiesmentioning

confidence: 99%

Brain Findings Associated with Iodine Deficiency Identified by Magnetic Resonance Methods: A Systematic Review

Hernández¹,

Wilson²,

Combet³

et al. 2013

OJRad

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Objectives: Iodine deficiency (ID) is a common cause of preventable brain damage and mental retardation worldwide, according to the World Health Organisation. It may adversely affect brain maturation processes that potentially result in structural and metabolic brain abnormalities, visible on Magnetic Resonance (MR) techniques. Currently, however, there has been no review of the appearance of these brain changes on MR methods. Methods: A systematic review was conducted using 3 online search databases (Medline, Embase and Web of Knowledge) using multiple combinations of the following search terms: iodine, iodine deficiency, magnetic resonance, MRI, MRS, brain, imaging and iodine deficiency disorders (i.e. hypothyroxinaemia, congenital hypothyroidism, hypothyroidism and cretinism). Results: Up to May 2013, 1673 related papers were found. Of these, 29 studies confirmed their findings directly using MR Imaging and/or MR Spectroscopy. Of them, 28 were in humans and involved 157 subjects, 46 of whom had primary hypothyroidism, 97 had congenital hypothyroidism, 3 had endemic cretinism and 11 had subclinical hypothyroidism. The studies were small, with a mean relevant sample size of 6, median 2, range 1 -35, while 14 studies were individual case reports. T1-weighted was the most commonly used MRI sequence (20/29 studies) and 1.5 Tesla was the most commonly used magnet strength (6/10 studies that provided this information). Pituitary abnormalities (18/29 studies) and cerebellar atrophy (3/29 studies) were the most prevalent brain abnormalities found. Only fMRI studies (3/29) reported cognition-related abnormalities but the brain changes found were limited to a visual description in all studies. Conclusions: More studies that use MR methods to identify changes on brain volume or other global structural abnormalities and explain the mechanism of ID causing thyroid dysfunction and hence cognitive damage are required. Given the role of MR techniques in cognitive studies, this review provides a starting point for researching the macroscopic structural brain changes caused by ID.

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“…A detection limit of about 200 ng g -1 was attained at the analysis of biological samples by instrumental NAA with epithermal neutrons (EINAA) using a relatively low neutron flux reactor [6], and it could be lowered to about 20 ng g -1 if combined with a Compton suppression counting system [7]. Using radiochemical NAA (RNAA), even better detection limits could be obtained (down to ng g -1 level) [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Determination of iodine in foodstuffs consumed in libya using instrumental and radiochemical neutron activation analysis

et al. 2006

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Iodine was determined in foodstuffs consumed in Libya employing two modes of NAA. The first mode was instrumental using short-time irradiation with epithermal neutrons behind a Cd shield (EINAA). The other mode utilized short-time irradiation with the reactor-pile neutrons followed by radiochemical separation (RNAA). The radiochemical separation procedure was based on the alkaline-oxidative fusion of samples and extraction of elemental iodine into chloroform. Separation yield determined using the radiotracer 131 I was within the range of 90 to 95 %. For quality control purposes, standard reference materials were analyzed in both modes employed. Using RNAA, a detection limit of ~1 ng g -1 could be obtained indicating superiority of the method in measuring ultra-trace levels of iodine. On the other hand, more than one order of magnitude higher detection limit did not allow sufficiently accurate determination of iodine in Libyan foodstuffs using EINAA.

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Iodine concentration in different human brain parts

Cited by 12 publications

References 27 publications

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

A Review of Spectrophotometric and Chromatographic Methods and Sample Preparation Procedures for Determination of Iodine in Miscellaneous Matrices

Brain Findings Associated with Iodine Deficiency Identified by Magnetic Resonance Methods: A Systematic Review

Determination of iodine in foodstuffs consumed in libya using instrumental and radiochemical neutron activation analysis

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