Trabecular Bone Score in Overweight and Normal-Weight Young Women

Berro, Abdel-Jalil; Ayoub, Marie-Louise; Pinti, Antonio; Ahmaı̈di, Saı̈d; Khoury, Georges; Khoury, César El; Zakhem, Eddy; Cortet, Bernard; Hage, Rawad El

doi:10.1007/978-3-319-78759-6_6

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…Currently, there is consistent evidence about the important role of weight-dependent loading of the skeleton in establishing and maintaining bone mass and strength during development. The direct pathway for weight to influence bone is thought to be mechanical loading [30,31]. In accordance with these data, our findings support the positive association between BMI and bone outcomes.…”

Section: Discussionsupporting

confidence: 90%

Body Mass Index, Lean Mass, and Body Fat Percentage as Mediators of the Relationship between Milk Consumption and Bone Health in Young Adults

et al. 2019

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Identifying environmental factors that influence bone health is crucial for developing effective intervention strategies that maximize peak bone mass. The aim of this study was to estimate the relationship between milk consumption and bone mineral density (BMD) in young adults, and to examine whether this relationship is mediated by body mass index (BMI) and total lean and fat mass. A cross-sectional study involving college students (n = 239) from a Spanish public university was performed. Data on milk consumption and anthropometric and body composition variables were collected. The Pearson correlation coefficients among total body BMD, body composition variables, and milk consumption ranged from −0.111 to −1.171, most of them statistically significant (p < 0.05). The ANCOVA (analysis of covariance) models showed that those with higher regular milk consumption had less total body BMD than those with lower regular milk consumption (p < 0.05), even after controlling for different sets of confounders. In the mediation analysis, BMI and lean and fat mass turned out to act as full mediators of the relationship between regular milk consumption and total body BMD (z = −1.7148, −1.3208, and −1.8549, respectively; p ≤ 0.05). In conclusion, milk consumption, per se, does not seem to have a direct effect on bone development, because its association seems to be fully mediated by body composition variables in young adults.

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Section: Discussionsupporting

confidence: 90%

Body Mass Index, Lean Mass, and Body Fat Percentage as Mediators of the Relationship between Milk Consumption and Bone Health in Young Adults

et al. 2019

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“…A relatively recent measure, the trabecular bone score (TBS), has gained some interest in this regard. 8 The trabecular bone score is a texture parameter inferred from recording gray pixel variations in DXA images. Higher scores mean stronger microarchitecture, more resilient to fracture and vice versa.…”

Section: Characteristics Of Studiesmentioning

confidence: 99%

Body mass index inversely associated with bone microarchitecture quality: a systematic review and meta-analysis

Kusuman

Wiryadana

Setiawan

et al. 2022

IJBS

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Introduction: The rising prevalence of obesity forces the orthopedist to consider it in fracture risk assessment. Multiple studies have consistently demonstrated that people with obesity have increased bone mineral density (BMD). Although it appears other factors in bone strength may influence the fracture risk, including bone microarchitecture, which recently can be measured by trabecular bone score (TBS). The complex associations between TBS and BMI remain unclear, and some studies show inconsistent findings. This systematic review and meta-analysis aimed to understand whether increased BMI is associated with lower TBS by indirectly pooling all the available evidence from the published literature. Methods: A literature search was carried out using PubMed, Cochrane Library, Google Scholar and other popular journal databases using the terms "trabecular bone score", "body mass index" and the possible synonyms. We extracted the total sample, mean and standard deviation of TBS for patients within each BMI category from the selected literature. A meta-analysis was conducted using a random-effects model and inverse variant methods to synthesize the pooled effect size (mean difference) for each gender subgroup. Results: After an initial search and screening of 2399 studies, seven reports published between 2016-2019 were included (five cross-sectional, one cohort, and one randomized clinical trial). These include 2872 samples which were mostly women (2286). One thousand thirty-one samples were with normal BMI, 1124 samples were with overweight BMI, and 717 samples were with obesity. The included studies varied by age group and gender. The between-study heterogeneity with I2 index ranging 0%-76% studies in man showed higher heterogeneity. Compared with normal individuals, those with overweight and obesity had lower TBS with a mean difference of -0.02 (95% CI -0.03 to -0.01) and -0.07 (95% CI, -0.09 to -0.05), respectively. The differences were consistent across gender, although larger differences were found in men. Conclusion: Individuals with higher BMI have a lower TBS than individuals with normal BMI in a stepwise manner. It suggests that the inclusion of TBS can improve the assessment of fracture risk in obese individuals.

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Intrapopulation variation in lower limb trabecular architecture

Mulder

Stock

Saers

et al. 2020

American J Phys Anthropol

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ObjectivesTrabecular structure is frequently used to differentiate between highly divergent mechanical environments. Less is known regarding the response of the structural properties to more subtle behavioral differences, as the range of intrapopulation variation in trabecular architecture is rarely studied. Examining the extent to which lower limb trabecular architecture varies when inferred mobility levels and environment are consistent between groups within a relatively homogenous population may aid in the contextualization of interpopulation differences, improve detectability of sexual dimorphism in trabecular structure, and improve our understanding of trabecular bone functional adaptation.Materials and methodsThe study sample was composed of adult individuals from three high/late medieval cemeteries from Cambridge (10th–16th c.), a hospital (n = 57), a parish cemetery (n = 44) and a friary (n = 14). Trabecular architecture was quantified in the epiphyses of the femur and tibia, using high resolution computed tomography.ResultsThe parish individuals had the lowest bone volume fraction and trabecular thickness in most regions. Multiple sex differences were observed, but the patterns were not consistent across volumes of interest.DiscussionDifferences between the three groups highlight the great variability of trabecular bone architecture, even within a single sedentary population. This indicates that trabecular bone may be used in interpreting subtle behavioral differences, and suggests that multiple archaeological sites need to be studied to characterize structural variation on a population level. Variation in sex and group differences across anatomical locations further demonstrates the site‐specificity in trabecular bone functional adaptation, which might explain why little consistent sexual dimorphism has been reported previously.

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Trabecular Bone Score in Overweight and Normal-Weight Young Women

Cited by 5 publications

References 30 publications

Body Mass Index, Lean Mass, and Body Fat Percentage as Mediators of the Relationship between Milk Consumption and Bone Health in Young Adults

Body Mass Index, Lean Mass, and Body Fat Percentage as Mediators of the Relationship between Milk Consumption and Bone Health in Young Adults

Body mass index inversely associated with bone microarchitecture quality: a systematic review and meta-analysis

Intrapopulation variation in lower limb trabecular architecture

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