Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox

Jose, Antresa; Cherian, Kripa Elizabeth; Nandyal, Munaf Babajan; Jiwanmall, Stephen Amarjeet; Kattula, Dheeraj; Paul, Thomas; Kapoor, Nitin

doi:10.3390/medsci9040069

Cited by 4 publications

(3 citation statements)

References 46 publications

(58 reference statements)

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“…A study from India indicated that individuals with BMI ≥ 35 kg/m 2 have a lower BMD than those with BMI ≥ 25–35 kg/m 2 . (0.723 gm/cm 2 versus 0.762 gm/cm 2 ; P 0.002) [ 12 ]. Another study from China based on 8365 adolescents aged 12–15 years concluded that obese subjects had a higher risk of having low BMD compared to subjects of normal weight for both sexes [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Association between obesity and bone mineral density in middle-aged adults

2022

J Orthop Surg Res

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Background The relationship between obesity and bone mineral density (BMD) varies in different studies. Our aim in this study was to explore the association between obesity (body mass index ≥ 30) and BMD among adults 40–59 years of age. Methods This study was conducted on a sample of 2218 participants (986 men and 1232 women) aged 40 to 59 years from the National Health and Nutrition Examination Survey 2011–2018. The independent variable was body mass index (BMI). The outcome variable was lumbar BMD. The associations of BMI with lumbar BMD were examined using multivariable linear regression models. Results BMI was positively associated with lumbar BMD after adjusting for other covariates [β 0.006; 95% confidence interval (CI) 0.003–0.008]. An inverted U-shaped association between BMI and lumbar BMD was further identified, with the point of infection at approximately 50 kg/m2. In the subgroup analyses, the relationship between BMI and lumbar BMD in women and blacks was an inverted U-shape. Conclusion Based on the results, it may be beneficial to appropriately increase BMI to promote BMD. However, considering the inverted U-shaped association, excessive BMI may be harmful to bone health in women and blacks.

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Section: Discussionmentioning

confidence: 99%

Association between obesity and bone mineral density in middle-aged adults

2022

J Orthop Surg Res

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“…31 Importantly, if a fracture injury occurs, the presence of obesity tends to hamper repair 32 and may disrupt bone morphology via inflammatory and other mechanisms 33,34 as identified in a laboratory study by Stephen et al, 35 and may be especially accentuated in those categorized as being morbidly obese. 36 As concluded by Crivelli et al, 37 when these findings are viewed concurrently, they tend to suggest that both visceral and subcutaneous fat may be detrimental for bone health in pre-and postmenopausal women, and that severe obesity may increase the risk of vertebral fractures, even in young women. Moreover, Copes et al, 38 note that the belief that obesity confers protection against bone fractures may yet be challenged if other conditions affecting people with obesity, such as type 2 diabetes and chronic kidney disease that can cause bone loss, poor bone quality and increased risk of hip and spine fractures are overlooked.…”

Section: Resultsmentioning

confidence: 97%

Obesity and bone health: key 2020–2022 highlights and implications

Marks¹

2022

AOWMC

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Sound bone health is crucial for life affirming activities, but is bone physiology impacted in the face of excess body weight? Since fractures and osteoporosis are on the rise, is obesity a risk factor for, as well as a possible negative albeit remediable correlate of bone health in the older adult? To examine this premise the PUBMED and GOOGLE SCHOLAR data bases were sourced for relevant data published between January 1 2020 and November 1 2022 in an effort to capture post COVID-19 possible research observations on the topic. These data bases show while a pervasive idea has been that obesity may be beneficial in some respects to bone mineral density attributes and impart fracture protection, several current publications tend to portray a negative impact of obesity on bone health via multiple proposed mechanisms. However, the research points to a strong need for continued research as well as clinical vigilance of vulnerable individuals both young and old in a period where obesity rates in all age groups appear to be on the rise, along with cases of bone fragility and osteoarthritis that can both foster high morbidity and mortality rates and possibly more challenging weight issues in the face of painful fractures or joint derangement.

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“…However, more recent literature has suggested that this does not hold true in those with morbid obesity. [ 119 ]…”

Section: T He a Ssociation With ...mentioning

confidence: 99%

Subclinical kwashiorkor in adults: A new age paradigm

Kapoor¹,

Bhattacharya²,

Agarwal³

et al. 2022

Indian J Endocr Metab

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Childhood protein-energy undernutrition (PEU) is a well-recognized problem and therefore a lot of work has been done to identify and manage paediatric PEU. Though there have been several reports of low protein consumption in adults from developing countries, PEU and its subtle forms (subclinical PEU) are not yet recognized as adult disorders. Physicians and public perception do not favour easy recognition and action. In this review, the authors provide a scoping review of the existing literature on this entity providing insights into its recognition, pathogenesis and management. Adult subclinical PEU is an enormous under-recognized challenge that can have detrimental consequences if not recognized and corrected in time. PEU has grave health and economic impact on the patient and society. Therefore, it is important to recognize subclinical PEU and prevent its progression to full-blown form.

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Trabecular Bone Score and Bone Mineral Density in Postmenopausal Women with Morbid Obesity—A Clinical Paradox

Cited by 4 publications

References 46 publications

Association between obesity and bone mineral density in middle-aged adults

Association between obesity and bone mineral density in middle-aged adults

Obesity and bone health: key 2020–2022 highlights and implications

Subclinical kwashiorkor in adults: A new age paradigm

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