Trabecular bone remodeling: An experimental model

Goldstein, Steven A.; Matthews, Larry S.; Kuhn, Janet L.; Hollister, Scott J.

doi:10.1016/0021-9290(91)90384-y

Cited by 174 publications

(89 citation statements)

References 35 publications

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“…It is generally accepted that this relationship between bone morphology (density/micro-architecture) and loading is the result of a local load-adaptive bone remodeling process regulated and carried out by bone cells in such a way that bone tissue is added to high-load locations and removed from low-load locations ('Wolff's law') (Schulte et al 2011;Adams et al 1997;Forwood and Turner 1995;Goldstein et al 1991;Rubin and Lanyon 1987;Frost 1987;Wolff 1892). This implies that, eventually, all bone tissue should be loaded uniform, thus producing a bone morphology that is optimized for the external loading history that it is subjected to.…”

Section: Introductionmentioning

confidence: 99%

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Christen

Rietbergen

Lambers

et al. 2011

Biomech Model Mechanobiol

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Bone adapts its morphology (density/microarchitecture) in response to the local loading conditions in such a way that a uniform tissue loading is achieved ('Wolff's law'). This paradigm has been used as a basis for bone remodeling simulations to predict the formation and adaptation of trabecular bone. However, in order to predict bone architectural changes in patients, the physiological external loading conditions, to which the bone was adapted, need to be determined. In the present study, we developed a novel bone loading estimation method to predict such external loading conditions by calculating the loading history that produces the most uniform bone tissue loading. We applied this method to murine caudal vertebrae of two groups that were in vivo loaded by either 0 or 8 N, respectively. Plausible load cases were sequentially applied to micro-finite element models of the mice vertebrae, and scaling factors were calculated for each load case to derive the most uniform tissue strainenergy density when all scaled load cases are applied simultaneously. The bone loading estimation method was able to predict the difference in loading history of the two groups and the correct load magnitude for the loaded group. This result suggests that the bone loading history can be estimated from its morphology and that such a method could be useful for predicting the loading history for bone remodeling studies or at sites where measurements are difficult, as in bone in vivo or fossil bones.

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Section: Introductionmentioning

confidence: 99%

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Christen

Rietbergen

Lambers

et al. 2011

Biomech Model Mechanobiol

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“…[10][11][12][13] In vivo intermittent compressive loading via a hydraulic bone chamber stimulated bone matrix synthesis in trabecular bone of the canine tibial and femoral metaphyses. 14 While clearly showing adaptive changes in bone to loading, the morbidity of this model limited its broader application.…”

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confidence: 99%

Trabecular bone adaptation to loading in a rabbit model is not magnitude‐dependent

Yang¹,

Willie²,

Beach³

et al. 2013

Journal Orthopaedic Research

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Although mechanical loading is known to influence trabecular bone adaptation, the role of specific loading parameters requires further investigation. Previous studies demonstrated that the number of loading cycles and loading duration modulate the adaptive response of trabecular bone in a rabbit model of applied loading. In the current study, we investigated the influence of load magnitude on the adaptive response of trabecular bone using the rabbit model. Cyclic compressive loads, producing peak pressures of either 0.5 or 1.0 MPa, were applied daily (5 days/week) at 1 Hz and 50 cycles/day for 4 weeks post-operatively to the trabecular bone on the lateral side of the distal right femur, while the left side served as an nonloaded control. The adaptive response was characterized by microcomputed tomography and histomorphometry. Bone volume fraction, bone mineral content, tissue mineral density, and mineral apposition rate (MAR) increased in loaded limbs compared to the contralateral control limbs. No load magnitude dependent difference was observed, which may reflect the critical role of loading compared to the operated, nonloaded contralateral limb. The increased MAR suggests that loading stimulated new bone formation rather than just maintaining bone volume. The absence of a dose-dependent response of trabecular bone observed in this study suggests that a range of load magnitudes should be examined for biophysical therapies aimed at augmenting current treatments to enhance long-term fixation of orthopedic devices. Keywords: trabecular bone; bone adaptation; rabbit; microcomputed tomography; mechanical stimulation Mechanical loading plays a central role in skeletal development and maintenance via both modeling and remodeling processes. 1-3 Throughout life the skeleton adapts by changing bone mass and architecture to the functional demands placed on it by mechanical stimuli. In cortical bone, loading must be dynamic rather than static to elicit an anabolic response 4 and adaptive remodeling is preferentially responsive to short periods of strain change. 5 For example, high-magnitude strains, varied by regulating the applied load 6-8 and strain rate, 9 enhanced cortical bone mass.Age-related bone loss, disuse-related bone loss, bone healing, and osseointegration around implants are all intimately coupled with the mechanical loading environment in trabecular bone. Despite the importance of studies on cortical diaphyseal bone adaptation to mechanical loading, prevention and treatment of osteoporosis and osteoarthritis requires investigation of trabecular bone adaptation. In addition, important questions remain concerning trabecular bone functional adaptation to a variety of loading parameters.Well-controlled and minimally invasive experimental models of loading in trabecular bone have been difficult to develop. [10][11][12][13] In vivo intermittent compressive loading via a hydraulic bone chamber stimulated bone matrix synthesis in trabecular bone of the canine tibial and femoral metaphyses. 14 While clearl...

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“…7). Goldstein et al (1991) observed continued remodeling and woven bone in that particular animal suggesting that a damage repair response was initiated.…”

Section: Micro-structural Modelingmentioning

confidence: 84%

From Structure to Process, From Organ to Cell: Recent Developments of FE-Analysis in Orthopaedic Biomechanics

Huiskes

Hollister

1993

Journal of Biomechanical Engineering

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126

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The introduction of finite element analysis (FEA) into orthopaedic biomechanics allowed continuum structural analysis of bone and bone-implant composites of complicated shapes (Huiskes and Chao, J. Biomechanics, Vol. 16, 1983, pp. 385–409). However, besides having complicated shapes, musculoskeletal tissues are hierarchical composites with multiple structural levels that adapt to their mechanical environment. Mechanical adaptation influences the success of many orthopaedic treatments, especiallly total joint replacements. Recent advances in FEA applications have begun to address questions concerning the optimality of bone structure, the processes of bone remodeling, the mechanics of soft hydrated tissues, and the mechanics of tissues down to the microstructural and cell levels. Advances in each of these areas, which have brought FEA from a continuum stress analysis tool to a tool which plays an ever-increasing role in the scientific understanding of tissue structure, adaptation, and the optimal design of orthopaedic implants, are reviewed.

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Trabecular bone remodeling: An experimental model

Cited by 174 publications

References 35 publications

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Trabecular bone adaptation to loading in a rabbit model is not magnitude‐dependent

From Structure to Process, From Organ to Cell: Recent Developments of FE-Analysis in Orthopaedic Biomechanics

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