From Structure to Process, From Organ to Cell: Recent Developments of FE-Analysis in Orthopaedic Biomechanics

Huiskes, R.; Hollister, Scott J.

doi:10.1115/1.2895534

Cited by 126 publications

(80 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Initially, this method was used to investigate questions of structural failure (Huiskes and Hollister, 1993). Currently, this method is successfully used in the context of understanding the biomechanical behavior of the bone under physiological loading conditions.…”

Section: Discussionmentioning

confidence: 99%

Finite‐element modeling of the anthropoid mandible: The effects of altered boundary conditions

2005

View full text Add to dashboard Cite

Finite-element modeling provides a full-field method for describing the stress environment of the skull. The utility of finite-element models, however, remains uncertain given our ignorance of whether such models validly portray states of stress and strain. For example, the effects of boundary conditions that are chosen to represent the mechanical environment in vivo are largely unknown. We conducted an in vitro strain gauge experiment on a fresh, fully dentate adult mandible of Macaca fascicularis to model a simplified loading regime by finite-element analysis for purposes of model validation. Under various conditions of material and structural complexity, we constructed dentate and edentulous models to measure the effects of changing boundary conditions (force orientation and nodal constraints) on strain values predicted at the gauge location. Our results offer a prospective assessment of the difficulties encountered when attempting to validate finite-element models from in vivo strain data. Small errors in the direction of load application produce significant changes in predicted strains. An isotropic model, although convenient, shows poor agreement with experimental strains, while a heterogeneous orthotropic model predicts strains that are more congruent with these data. Most significantly, we find that an edentulous model performs better than a dentate one in recreating the experimental strains. While this result is undoubtedly tied to our failure to model the periodontal ligament, we interpret the finding to mean that in the absence of occlusal loads, teeth within alveoli do not contribute significantly to the structural stiffness of the mandible. © 2005 Wiley-Liss, Inc. Key words: mandible; computed tomography; image reconstruction; finite-element methodFinite-element analysis (FEA) is the method of choice for theoretical analysis of the mechanical behavior of complex shapes in biology. The approach of FEA approximates real geometry using a large number of smaller simple geometric elements (e.g., triangles, bricks, tetrahedrons). Since complex shapes defy simple mathematical solution (i.e., in terms of engineering formulas), FEA simplifies a problem by analyzing multiple simple elements of known shapes with established mathematical solutions. These multiple solutions are in the end combined together to depict states of stress and strain through the entire structure.The last half of the 20th century saw increasing interest in testing and analysis of bone biomechanics (Cowin, 2001), including increased use of finite-element (FE) methods. Many theoretical and experimental studies have sought to quantify the distribution of stresses and strain in the mandible (Knoell, 1977;Hylander, 1984;Bouvier

show abstract

Section: Discussionmentioning

confidence: 99%

Finite‐element modeling of the anthropoid mandible: The effects of altered boundary conditions

2005

View full text Add to dashboard Cite

show abstract

“…Because the damage-accumulation process itself ciin now also be simulated (Figure 13), the actual endurance limits of reconstructions with new devices can be estimated. at least on a relative b with traditional reconstruction methods (Huiskes and Hollister 1993). FEA also produces infomiation about stress-shielding of the bone, interface motions and stresses at modular prosthetic connections.…”

Section: Finite-element Stress Analysis (Fea)mentioning

confidence: 99%

“…In recent years, however, methods of FE hone-remodeling analysis have been developed, which are suitable for simulating the bone-remodeling process in computer models (Huiskes and Hollister 1993). These models are based on strain-adaptive boneremodeling theory-quantitative formulations of Wolff's law-and they effectively estimate the longterm bone loss around hip stems with regard to shape, material and fit of a particular stem design (Huiskes et al 1092;Figure 14).…”

Section: Fe Bone-remodeling Analysismentioning

confidence: 99%

Failed innovation in total hip replacement: Diagnosis and proposals for a cure

Huiskes

1993

Acta Orthopaedica Scandinavica

Self Cite

206

109

View full text Add to dashboard Cite

“…FE has been used across the full spectrum of orthopaedic devices and there have been a number of thorough reviews (Huiskes and Chao, 1983;Huiskes and Hollister, 1993;Prendergast, 1997;Viceconti et al, 2009;Laz and Browne, 2010;Erdemir et al, 2012;Pankaj, 2013;Taylor et al, 2013;Carr and Goswami, 2009;Prendergast, 2001). The main focus of this review will be hip and knee replacement, as these have been studied the most, but the issues raised are applicable to the simulation of all orthopaedic devices.…”

Section: Introductionmentioning

confidence: 99%

Four decades of finite element analysis of orthopaedic devices: Where are we now and what are the opportunities?

Taylor

Prendergast

2015

Journal of Biomechanics

139

106

View full text Add to dashboard Cite

a b s t r a c tFinite element has been used for more than four decades to study and evaluate the mechanical behaviour total joint replacements. In Huiskes seminal paper "Failed innovation in total hip replacement: diagnosis and proposals for a cure", finite element modelling was one of the potential cures to avoid poorly performing designs reaching the market place. The size and sophistication of models has increased significantly since that paper and a range of techniques are available from predicting the initial mechanical environment through to advanced adaptive simulations including bone adaptation, tissue differentiation, damage accumulation and wear. However, are we any closer to FE becoming an effective screening tool for new devices? This review contains a critical analysis of currently available finite element modelling techniques including (i) development of the basic model, the application of appropriate material properties, loading and boundary conditions, (ii) describing the initial mechanical environment of the bone-implant system, (iii) capturing the time dependent behaviour in adaptive simulations, (iv) the design and implementation of computer based experiments and (v) determining suitable performance metrics.The development of the underlying tools and techniques appears to have plateaued and further advances appear to be limited either by a lack of data to populate the models or the need to better understand the fundamentals of the mechanical and biological processes. There has been progress in the design of computer based experiments. Historically, FE has been used in a similar way to in vitro tests, by running only a limited set of analyses, typically of a single bone segment or joint under idealised conditions. The power of finite element is the ability to run multiple simulations and explore the performance of a device under a variety of conditions. There has been increasing usage of design of experiments, probabilistic techniques and more recently population based modelling to account for patient and surgical variability. In order to have effective screening methods, we need to continue to develop these approaches to examine the behaviour and performance of total joint replacements and benchmark them for devices with known clinical performance.Finite element will increasingly be used in the design, development and pre-clinical testing of total joint replacements. However, simulations must include holistic, closely corroborated, multi-domain analyses which account for real world variability.

show abstract

From Structure to Process, From Organ to Cell: Recent Developments of FE-Analysis in Orthopaedic Biomechanics

Cited by 126 publications

References 68 publications

Finite‐element modeling of the anthropoid mandible: The effects of altered boundary conditions

Finite‐element modeling of the anthropoid mandible: The effects of altered boundary conditions

Failed innovation in total hip replacement: Diagnosis and proposals for a cure

Four decades of finite element analysis of orthopaedic devices: Where are we now and what are the opportunities?

Contact Info

Product

Resources

About