Trabectome outcomes across the spectrum of glaucoma disease severity

Ahmed, Sarah Farukhi; Bhatt, Anand; Schmutz, Mason; Mosaed, Sameh

doi:10.1007/s00417-018-4023-8

Cited by 22 publications

(16 citation statements)

References 12 publications

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“…A study by Ahmed et al15 using the Trabectome demonstrated a 6-month IOP of 15.7±4.0 mmHg and mean medications of 2.1±1.4, versus our observation of 15.0±3.0 mmHg and 1.2±1.4 medications.…”

Section: Discussioncontrasting

confidence: 98%

<p>Outcome of phacoemulsification combined with excisional goniotomy using the Kahook Dual Blade in severe glaucoma patients at 6 months</p>

Hirabayashi

King

Lee

et al. 2019

OPTH

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Purpose The aim of this study was to describe 6-month rates of achieving target IOP without requiring additional glaucoma surgery after excisional goniotomy using the Kahook Dual Blade combined with phacoemulsification (phaco-KDB) in patients with severe-stage glaucoma. Methods Retrospective review of 42 eyes from 36 patients with severe glaucoma who received phaco-KDB. Primary and secondary open-angle and combined-mechanism glaucoma were included. Preoperative, intraoperative, and postoperative data were collected through the 6-month follow-up period. The primary outcome was proportion of patients achieving IOP ≤15 mmHg without additional glaucoma procedures. Secondary outcomes were mean change in IOP, reduction of glaucoma medications, additional glaucoma procedures needed, and adverse events. Results Preoperative baseline mean IOP was 17.1±4.8 mmHg (mean ± SD) and number of medications was 2.4±1.3. At 6 months, 64.3% (27/42) of eyes had achieved IOP ≤15 mmHg without additional glaucoma procedures, 45.2% (19/42) reached this target IOP on fewer medications, and 31.0% (13/42) on no medications. Mean IOP reduction was 2.1±4.67 mmHg ( P =0.022) and mean medication reduction was 1.2±1.4 ( P ≤0.001). Visually significant complications were experienced by 7.1% (3/42) of eyes, and 7.1% (3/42) required additional IOP-lowering procedures within 6 months of surgery. Conclusion Patients with severe-stage open-angle glaucoma achieved significant IOP and medication reductions following phaco-KDB. Notably, about two-thirds of eyes achieved an IOP of ≤15 mmHg at 6 months without additional glaucoma procedures. Complications and need for additional procedures were rare. Phaco-KDB may be an effective and safe alternative to more invasive filtering surgery in many patients with severe glaucoma.

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Section: Discussioncontrasting

confidence: 98%

<p>Outcome of phacoemulsification combined with excisional goniotomy using the Kahook Dual Blade in severe glaucoma patients at 6 months</p>

Hirabayashi

King

Lee

et al. 2019

OPTH

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“…Given the minimally invasive nature of AIT, this figure justifies its application in eyes that do not undoubtedly qualify for filtering surgery, which has a less favorable safety profile. 4 The outcomes in our patients are consistent with several recent reports. 5 Though being a simple and safe outpatient procedure with topical anesthesia, trabectome surgery has not found broad acceptance in the community due to a low predictability of success in a given case and the absence of randomized clinical trials confirming its effect and success rates.…”

Section: Discussionsupporting

confidence: 93%

Effect of Preoperative Intraocular Pressure in Patients with and without Intolerance to Their IOP-Lowering Medication on the Outcome of Trabectome Surgery

Wons¹,

Mihic²,

Pfister³

et al. 2021

OPTH

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“…Exfoliative glaucoma was associated with a higher success rate [26]. In a series of eyes undergoing Trabectome with or without cataract extraction, IOP lowering was similar in eyes with mild compared to moderate to severe glaucoma [25].…”

Section: Trabectomementioning

confidence: 97%

“…The Trabectome handpiece needle tip pierces the trabecular meshwork and then circumferentially ablates the trabecular meshwork for 3 to 6 clock hours. It is approved in the USA for use with and without concurrent cataract surgery and across the spectrum of disease severity and subtypes [25].…”

Section: Trabectomementioning

confidence: 99%

An Update on Microinvasive Glaucoma Surgery Concurrent With Cataract Extraction

Tassel

Chen

2019

Curr Ophthalmol Rep

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Purpose of Review In this article, we review the current options for microinvasive glaucoma surgery (MIGS) combined with cataract extraction in the USA and the efficacy of the various approaches. Recent Findings MIGS is a rapidly growing area of research and clinical interest. Available surgeries aim to reduce intraocular pressure by improving aqueous outflow through the trabecular or subconjunctival pathways or by reducing aqueous production. Summary Multiple approaches to MIGS are utilized in clinical practice. On average, these surgeries are safe and modestly effective in reducing intraocular pressure. Future research will demonstrate which surgical approaches are most efficacious, whether and how to combine MIGS, and the role of MIGS in improving patient quality of life.

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Trabectome outcomes across the spectrum of glaucoma disease severity

Cited by 22 publications

References 12 publications

<p>Outcome of phacoemulsification combined with excisional goniotomy using the Kahook Dual Blade in severe glaucoma patients at 6 months</p>

<p>Outcome of phacoemulsification combined with excisional goniotomy using the Kahook Dual Blade in severe glaucoma patients at 6 months</p>

Effect of Preoperative Intraocular Pressure in Patients with and without Intolerance to Their IOP-Lowering Medication on the Outcome of Trabectome Surgery

An Update on Microinvasive Glaucoma Surgery Concurrent With Cataract Extraction

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