Effect of Preoperative Intraocular Pressure in Patients with and without Intolerance to Their IOP-Lowering Medication on the Outcome of Trabectome Surgery

Wons, Juliana; Mihic, Nadine; Pfister, Isabel B.; Anastasi, Stefano; Garweg, Justus G.; Halberstadt, Markus

doi:10.2147/opth.s303603

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…This is a retrospective, multisurgeon case study wherein we study the effectiveness of canaloplasty performed via an ab interno surgical technique in reducing IOP and medication dependence as a standalone procedure or in combination with cataract surgery in POAG patients, in mild-moderate vs. severe POAG, and controlled (≤18 mmHg) vs. uncontrolled (>18 mmHg) IOP eyes [ 27 , 28 ]. The eyes that were included in the group successfully controlled with medications at baseline, with an IOP equal to or less than 18 mmHg, were enrolled to reduce patient reliance on medications or due to intolerance to medications.…”

Section: Methodsmentioning

confidence: 99%

Long‐Term Clinical and Safety Outcomes of Canaloplasty Performed across All Grades of Glaucoma Severity

Patel

Reiss

2023

Journal of Ophthalmology

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Purpose. To investigate the clinical effectiveness of canaloplasty performed with an ab interno technique using the iTrack microcatheter (Nova Eye Medical) in patients with mild-moderate glaucoma as compared to severe glaucoma. Methods. This is a retrospective single-center case series. Patients were preoperatively categorized as mild/moderate vs. severe glaucoma assessed using the mean deviation (MD) score and controlled group (baseline intraocular pressure (IOP) ≤18 mmHg) vs. uncontrolled group (>18 mmHg). All patients with glaucoma were eligible for recruitment except those who had undergone previous glaucoma surgery (with the exception of selective laser trabeculoplasty or SLT). Patients underwent canaloplasty via an ab interno surgical technique with or without phacoemulsification and were monitored for IOP, glaucoma medication usage, and surgical complications. Results. In total, 72 eyes were followed for 3.4 ± 0.5 years. Mean pre-op IOP (mmHg) was 19.3 ± 7.7 in the standalone group (n = 9) and 18.5 ± 5.6 in the combined group (n = 63) ( p = 0.38 ). At the last follow-up, mean IOP reduced by 36% to 12.4 ± 4.4 ( p = 0.02 ) in the standalone group and by 26% to 13.7 ± 4.8 in the combined group ( p < 0.001 ). Mean pre-op IOP (mmHg) was 18.6 ± 5.2 in the severe group (n = 24) and 18.6 ± 6.2 in the mild-moderate group (n = 48) ( p = 0.48 ). Mean IOP was 14.1 ± 6.3 (−24%; p < 0.001 ) and 13.3 ± 3.7 (−29%; p < 0.001 ), respectively, at the last follow-up. Mean glaucoma medication usage decreased from 2.5 ± 0.9 to 2.1 ± 0.9 (−15%; p = 0.083 ) in the severe group and 2.3 ± 1.0 to 1.4 ± 1.3 (−40%; p < 0.001 ) in the mild/moderate group. There was one localized Descemet’s membrane detachment in the moderate group. Conclusion. iTrack canaloplasty achieved a statistically significant IOP reduction in mild-moderate and severe eyes and was found to be an effective option for reducing IOP and medications in patients with mild-moderate primary open-angle glaucoma (POAG). In severe eyes, it has reduced IOP while the medications remained stable.

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Section: Methodsmentioning

confidence: 99%

Long‐Term Clinical and Safety Outcomes of Canaloplasty Performed across All Grades of Glaucoma Severity

Patel

Reiss

2023

Journal of Ophthalmology

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“…The Trabectome is used to ablate the juxtacanalicular TM and reduce the outflow resistance of aqueous in order to lower IOP 38. The Trabectome has also been reported to be effective and safe in multiple types of glaucoma, including PACG 26,39,40…”

Section: Methodsmentioning

confidence: 99%

“…38 The Trabectome has also been reported to be effective and safe in multiple types of glaucoma, including PACG. 26,39,40 Ab interno canaloplasty (AbiC) is characterized by dilating the SC by lowering the distal resistance of aqueous outflow to decrease the IOP. [41][42][43][44][45] AbiC can effectively lower the IOP in eyes with POAG.…”

Section: Enhancing Aqueous Outflow Through Schlemm Canal Surgerymentioning

confidence: 99%

Minimally Invasive Glaucoma Surgery in Primary Angle-Closure Glaucoma

Song

Zhang

et al. 2022

Asia-Pacific Journal of Ophthalmology

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Primary angle-closure glaucoma (PACG) is responsible for half of the glaucoma-related blindness worldwide. Cataract surgery with or without trabeculectomy has been considered to be the first-line treatment in eyes with medically uncontrolled PACG. While minimally invasive glaucoma surgery has become an important surgical approach for primary open-angle glaucoma, its indications and benefits in PACG are less clear. This review summarizes the efficacy and safety profile of minimally invasive glaucoma surgery in PACG to unfold new insights into the surgical management of PACG.

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IOP-lowering and drug-sparing effects of trabectome surgery with or without cyclodialysis ab interno

Garweg

Pfister

Gerhardt

et al. 2023

Graefes Arch Clin Exp Ophthalmol

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Effect of Preoperative Intraocular Pressure in Patients with and without Intolerance to Their IOP-Lowering Medication on the Outcome of Trabectome Surgery

Cited by 6 publications

References 22 publications

Long‐Term Clinical and Safety Outcomes of Canaloplasty Performed across All Grades of Glaucoma Severity

Long‐Term Clinical and Safety Outcomes of Canaloplasty Performed across All Grades of Glaucoma Severity

Minimally Invasive Glaucoma Surgery in Primary Angle-Closure Glaucoma

IOP-lowering and drug-sparing effects of trabectome surgery with or without cyclodialysis ab interno

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