TPLS as predictive platform for twin-screw wet granulation process and formulation development

Ryckaert, Alexander; Hauwermeiren, Daan Van; Dhondt, Jens; Man, Alexander De; Funke, Adrian; Djurić, Dejan; Vervaet, Chris; Beer, Thomas De

doi:10.1016/j.ijpharm.2021.120785

Cited by 9 publications

(6 citation statements)

References 31 publications

(40 reference statements)

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“…In practice, the material library was presented in the form of tabular data, in which the rows were different materials, and the columns were material quality attributes. Table 1 shows the typical sizes of reported pharmaceutical material libraries after retrieving articles in Web of Science using “material library” or “material database” as key words [ 1 , 3 , 4 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. The material name and attributes in each material library are shown in Table S1 in the Supplementary Materials .…”

Section: Introductionmentioning

confidence: 99%

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Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct Compression Tablet Tensile Strength by Latent Variable Modeling

Cao,

Shen,

Zhao

et al. 2024

Pharmaceutics

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The material library is an emerging, new data-driven approach for developing pharmaceutical process models. How many materials or samples should be involved in a particular application scenario is unclear, and the impact of sample size on process modeling is worth discussing. In this work, the direct compression process was taken as the research object, and the effects of different sample sizes of material libraries on partial least squares (PLS) modeling in the prediction of tablet tensile strength were investigated. A primary material library comprising 45 materials was built. Then, material subsets containing 5 × i (i = 1, 2, 3, …, 8) materials were sampled from the primary material library. Each subset underwent sampling 1000 times to analyze variations in model fitting performance. Both hierarchical sampling and random sampling were employed and compared, with hierarchical sampling implemented with the help of the tabletability classification index d. For each subset, modeling data were organized, incorporating 18 physical properties and tableting pressure as the independent variables and tablet tensile strength as the dependent variable. A series of chemometric indicators was used to assess model performance and find important materials for model training. It was found that the minimum R2 and RMSE values reached their maximum, and the corresponding values were kept almost unchanged when the sample sizes varied from 20 to 45. When the sample size was smaller than 15, the hierarchical sampling method was more reliable in avoiding low-quality few-shot PLS models than the random sampling method. Two important materials were identified as useful for building an initial material library. Overall, this work demonstrated that as the number of materials increased, the model’s reliability improved. It also highlighted the potential for effective few-shot modeling on a small material library by controlling its information richness.

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Section: Introductionmentioning

confidence: 99%

“…Supplementary Materials S2: Table S2: The information of 45 materials including names, abbreviations, batch numbers suppliers and physical attributes. References [ 1 , 3 , 4 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ] are cited in the supplementary materials.…”

mentioning

confidence: 99%

Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct Compression Tablet Tensile Strength by Latent Variable Modeling

Cao,

Shen,

Zhao

et al. 2024

Pharmaceutics

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show abstract

“…In addition, porosity is an important property used to physically describe the wet granulation process, in particular granule consolidation behavior (Iveson et al, 1996). Nevertheless, most studies about TSWG investigated the effect of process parameters and material properties on granule attributes such as size, density and friability (Dhenge et al, 2010(Dhenge et al, , 2011(Dhenge et al, , 2012Vercruysse et al, 2015Vercruysse et al, , 2012Fonteyne et al, 2013Fonteyne et al, , 2015Vanhoorne et al, 2016;Meier et al, 2017;Portier et al, 2020a;Ryckaert et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation

Peeters

Jiménez

Matsunami

et al. 2023

International Journal of Pharmaceutics

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“…Experimental analyses were also performed for assessing the impact of material properties [8] and the screw configurations [9]. Sometimes, datadriven models were further developed to predict granule CQAs of different process settings [10] and formulations [11].…”

Section: Introductionmentioning

confidence: 99%

Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity

et al. 2023

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TPLS as predictive platform for twin-screw wet granulation process and formulation development

Cited by 9 publications

References 31 publications

Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct Compression Tablet Tensile Strength by Latent Variable Modeling

Sample Size Requirements of a Pharmaceutical Material Library: A Case in Predicting Direct Compression Tablet Tensile Strength by Latent Variable Modeling

Evaluation of the influence of material properties and process parameters on granule porosity in twin-screw wet granulation

Model development and calibration of two-dimensional population balance model for twin-screw wet granulation based on particle size distribution and porosity

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