TPH2 genotype is associated with PTSD’s avoidance symptoms in Chinese female earthquake survivors

Cao, Chengqi; Wang, Li; Wang, Richu; Qing, Yulan; Zhang, Jianxin

doi:10.1097/ypg.0000000000000048

Cited by 8 publications

(3 citation statements)

References 35 publications

(38 reference statements)

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“…Cao et al conducted a study of a total of 326 Chinese adults who lost their children during the Wenchuan disaster. They found that TPH2 rs11178997 genotype, an SNP located in the transcriptional control region, may play an important functional role in PTSD development and contributed to PTSD symptoms (Cao, Wang, Wang, Qing, & Zhang, 2014). This was consistent with a previous study on the TPH2 rs11178997 genotype in 200 adults exposed to the 1988 Spitak earthquake from 12 families (Goenjian et al, 2012).…”

Section: Gene â Environment (G â E)supporting

confidence: 64%

Systematic Review on Post-Traumatic Stress Disorder Among Survivors of the Wenchuan Earthquake

Hong

Efferth

2016

Trauma, Violence, & Abuse

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Post-traumatic stress disorder (PTSD) widely occurs among victims or witness of disasters. With flashbacks, hyperarousal, and avoidance being the typical symptoms, PTSD became a focus of psychological research. The earthquake in Wenchuan, China, on May 12, 2008, was without precedent in magnitude and aftermath and caused huge damage, which drew scientists' attention to mental health of the survivors. We conducted a systematic overview by collecting published articles from the PubMed database and classifying them into five points: epidemiology, neuropathology, biochemistry, genetics and epigenetics, and treatment. The large body of research during the past 6 years showed that adolescents and adults were among the most studied populations with high prevalence rates for PTSD. Genomic and transcriptomic studies focusing on gene × environment studies as well as epigenetics are still rare, although a few available data showed great potential to better understand the pathophysiology of PTSD as multifactorial disease. Phytotherapy with Chinese herbs and acupuncture are rarely reported as of yet, although the first published data indicated promising therapy effects. Future studies should focus on the following points: (1) The affected populations under observation should be better defined concerning individual risk factor, time of observation, spatial movement, and individual disease courses of patients. (2) The role of social support for prevalence rates of PTSD should be observed in more detail. (3) Efficacy and safety of Chinese medicine should be studied to find potential interventions and effective treatments of PTSD.

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Section: Gene â Environment (G â E)supporting

confidence: 64%

Systematic Review on Post-Traumatic Stress Disorder Among Survivors of the Wenchuan Earthquake

Hong

Efferth

2016

Trauma, Violence, & Abuse

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“…One hundred and forty (45.5%) participants self-reported as Han ethnicity, 161 (52.3%) as Qiang, and seven (2.3%) as other ethnicities in China (including Hui and Tibetan). The current study is part of a larger project involving this sample, and other aspects of the project have been reported elsewhere Cao, Wang, Wang, Qing, & Zhang, 2014;Wang et al, 2013).…”

Section: Participantsmentioning

confidence: 99%

The COMT gene variant is associated with depression's decreased positive affect symptoms in Chinese adults

Cao

Wang

et al. 2014

PsyCh Journal

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This study examined the association between the COMT Val(158) Met genotype and depression symptoms. A total of 326 Chinese adults who experienced the deadly 2008 Wenchuan earthquake and lost children during the disaster participated in this study. Depression symptoms were measured using the Center for Epidemiological Studies Depression Scale (CES-D). The single nucleotide polymorphism (SNP) was successfully genotyped using the MassARRAY system. Results indicated that although the Val(158) Met genotype was not associated with total depression symptoms, it was significantly correlated with decreased positive affect symptoms of depression in males. The findings indicated that COMT may play an important functional role in the development of depression, and contribute to the extant knowledge of the genetic basis and sex-specific expression of symptoms in depression.

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“…It is estimated that due to this disaster, 400,000 urban people had lost their jobs, more than 5 million farmers' crops were destroyed, and the total economic loss exceeded 150 billion dollars. [10] Among the post-disaster mental problems, PTSD is the most harmful one. PTSD is a serious and lasting disorder that develops after exposure to events that cause psychological trauma, such as earthquakes or tsunamis.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of post-traumatic stress disorder after earthquakes among the elderly in China: A meta-analysis

Hong¹,

Liu²,

Xu³

et al. 2021

World Journal of Emergency Medicine

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BACKGROUND: The study aims to investigate the occurrence of post-traumatic stress disorder (PTSD) after earthquakes among the elderly. METHODS: Data from cross-sectional studies focusing on the prevalence of PTSD after earthquakes among the elderly were collected from PubMed, EMBASE, Cochrane Library, and China National Knowledge Infrastructure in December 2019. The search terms included post-traumatic stress disorder, earthquake, and elderly. This study used Review Manager 5.0 to evaluate the impact of the results. In addition, forest plots, sensitivity analysis, and bias analysis were carried out on the included articles. The combined estimate of the risk ratio and the standard deviation of the 95% confi dence interval (95% CI) were measurements of the size of the eff ect. RESULTS: There were 4,834 patients included from 10 eligible studies. The sample sizes of PTSD group and non-PTSD group were 1,277 and 3,557, respectively. The meta-analysis showed that the overall occurrence of PTSD after earthquakes among the elderly was 0.25; the occurrence in females was higher than that in males, and the occurrence in the same province indicated little diff erence (Wenchuan city 0.25 and Ya'an city 0.24). CONCLUSIONS: After earthquakes, the occurrence of PTSD is higher among the elderly than among other age groups, and higher among the females than among the males, while there is little difference among different areas within the same province. This indicated that prioritized specific psychological interventions should be provided to the aged and the females.

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TPH2 genotype is associated with PTSD’s avoidance symptoms in Chinese female earthquake survivors

Cited by 8 publications

References 35 publications

Systematic Review on Post-Traumatic Stress Disorder Among Survivors of the Wenchuan Earthquake

Systematic Review on Post-Traumatic Stress Disorder Among Survivors of the Wenchuan Earthquake

The COMT gene variant is associated with depression's decreased positive affect symptoms in Chinese adults

Prevalence of post-traumatic stress disorder after earthquakes among the elderly in China: A meta-analysis

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