TP53 codon 72 Polymorphism and bladder cancer risk: a meta-analysis and emphasis on the role of tumor or smoking status

Abstract

Background: Various studies had explored the relationship between TP53 codon 72 polymorphisms and the risk of bladder cancer (BC). However, their results remained inconsistent and the definite role of smoking or tumor status associated with this polymorphism in BC cases was seldom involved. Hence, this meta-analysis was to disclose such associations.Methods: Systematical and comprehensive retrieval of online databases PubMed, PMC, EMBASE and Web of Science were conducted to obtain eligible studies, up to May 30th, 2018. Pooled odds ratios (ORs) with 95% confidence intervals (CI) were utilized to assess the associations between TP53 codon 72 polymorphisms and BC susceptibilities under five genetic comparison models.Results: Ultimately, this meta-analysis enrolled 22 applicable studies with 3,791 BC cases and 4,917 controls. Our results suggested that the variant genotypes were associated with BC risk in Asian subgroup (allele model: OR=1.19, 95% CI=1.04-1.34; dominant model: OR=1.27, 95% CI=1.06-1.52; homozygote model: OR=1.36, 95% CI=1.03-1.80), while negative outcomes were presented in Caucasians. In the relationship between TP53 codon 72 polymorphisms and BC tumor stage in Asian group, positive results were presented in allele model: OR=1.68, 95% CI=1.04-2.72; dominant model: OR=2.46, 95% CI=1.08-5.61; heterozygous model: OR=2.32, 95% CI=1.04-5.14; homozygote model: OR=2.66, 95% CI=1.04-6.81. However, no evidence was revealed between this polymorphism and BC tumor grade. Besides, significant associations were displayed between TP53 codon 72 polymorphism and smoking status (allele model: OR=1.40, 95% CI=1.06-1.84; dominant model OR=1.72, 95% CI=1.18-2.50; heterozygous model: OR=1.77, 95% CI=1.19-2.64).Conclusion: Taken together, our results shed light on that TP53 codon 72 polymorphism was significantly associated with the susceptibility to BC in Asians. In addition, positive associations were also revealed between this polymorphism and tumor stage/smoking status in BC cases.

Dietary fat intake and risk of bladder cancer: Evidence from a meta-analysis of observational studies

“…It was estimated that there were 430,000 new cases and 165,000 bladder cancer deaths in 2012 (2). Risk factors such as genetic factors (3,4), secondhand smoking (5), diabetes mellitus (6), vitamin A (7), fruits and vegetables (8) and so on had been well documented. Previous paper had been suggested that dietary may be an important factors in the development of bladder cancer because many dietrelated metabolites were in direct contacting with the bladder epithelium during excretion (9).…”

Associations of MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) Polymorphisms with Susceptibility to Bladder Cancer: A Systematic Review and Meta-Analysis

“…According to our findings, the association of the MTHFR rs1801133 (677C>T) and rs180113 (1298A>C) polymorphisms with bladder cancer may be due to differences in ethnicity, genetic background, life style, smoking habits, and etc. in a meta-analysis, Zhang et al, (2018) verified the relationship between TP53 codon 72 and bladder cancer risk in Asians, but not Caucasians. These results indicated that genetic variants might be an ethnicity related factor of susceptibility to bladder cancer.…”

Combined Genotype Effects of <b><i>TP53</i></b> and <b><i>PAI-1</i></b> Polymorphisms in Breast Cancer Susceptibility: Multifactor Dimensionality Reduction and in silico Analysis

“…Polymorphisms in PAI-1 and TP53 genes may be involved in their expression and thus contribute to breast cancer susceptibility, progression, and therapeutic responses [22, 34]. Various studies have suggested the association of these polymorphisms in the development of various cancers including endometrium, colorectal, lung, and breast cancers [14, 22, 35]. In this current paper, we investigated the effects of 2 polymorphisms of codon 72 in TP53 and 4G/5G of PAI-1 in Iranian-Azeri women with the risk of breast cancer.…”