Combined Genotype Effects of &lt;b&gt;&lt;i&gt;TP53&lt;/i&gt;&lt;/b&gt; and &lt;b&gt;&lt;i&gt;PAI-1&lt;/i&gt;&lt;/b&gt; Polymorphisms in Breast Cancer Susceptibility: Multifactor Dimensionality Reduction and in silico Analysis

Pouladi, Nasser; Shavali, Mojtaba; Abdolahi, Sepehr

doi:10.1159/000514398

Cited by 6 publications

(2 citation statements)

References 38 publications

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“…No other articles were found from the references manually. A total of 37 articles were identified in this article, which included 33 articles with 9550 cases and 10431 controls samples for the rs1799889 polymorphism, 8,12 -43 5 articles with 2705 cases and 3168 controls samples for the rs2227631 polymorphism 23,38,41,44,45 and 4 articles with 2799 cases and 4011 controls samples for the rs2227667 polymorphism. 44 -47…”

Section: Resultsmentioning

confidence: 99%

PAI-1 Polymorphisms Have Significant Associations With Cancer Risk, Especially Feminine Cancer

Peng

Guo

Li³

2021

Technol Cancer Res Treat

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Background: The plasminogen activator inhibitor-1 (PAI-1) was found in many types of tumor cells, which involved in tumorigenesis. Some studies investigated the associations between PAI-1 polymorphisms and various cancers, but the results were inconsistent. So this study did a meta-analysis to assess the strength of relationship between PAI-1 and cancer. Methods: Articles that meet the requirements were searched from PubMed, EMBASE, MEDLINE, Scopus, CNKI, Wanfang and SinoMed electronic databases before June 17th 2021. Stata version 11.2 was performed to merge the odds ratios (ORs) values and calculate 95% confidence intervals (CIs). Stratified analyses were assessed on the basis of types of cancer, ethnicity and source of the control group. Heterogeneity and sensitivity analysis were tested, and publication bias was also estimated. A meta-regression analysis was applied to explore sources of heterogeneity. The false-positive report probabilities (FPRP) and the Bayesian False Discovery Probability (BFDP) test were used to assess the credibility of statistically significant associations. Results: Ultimately, in this study, 33 eligible reports were included with 9550 cases and 10431 controls for the rs1799889 polymorphism, 5 reports with 2705 cases and 3168 controls for the rs2227631 polymorphism, and 4 reports with 2799 cases and 4011 controls for the rs2227667 polymorphism. The ORs and 95% CIs showed a statistically significant relationship between rs1799889 4G>5G polymorphism and cancer risk, especially in feminine cancer. The term refers to cancers that occur in the female reproductive system, such as ovarian, breast, endometrial and cervical cancer. Moreover, there was no association observed for the PAI-1 promoter A>G polymorphism (rs2227631 and rs2227667). In further subgroup analyses of 4G>5G polymorphism (rs1799889), an increased susceptibility to cancer was observed in Caucasians group and some types of cancer groups. Conclusions: This article comes to a conclusion that the rs1799889 polymorphism might help to increase the risk of cancer; moreover, the susceptibility to feminine cancer is more evident.

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Section: Resultsmentioning

confidence: 99%

PAI-1 Polymorphisms Have Significant Associations With Cancer Risk, Especially Feminine Cancer

Peng

Guo

Li³

2021

Technol Cancer Res Treat

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“…Furthermore, the multifactor dimensionality reduction (MDR) method was used to generate the best 1-dimensional model to do for the detection and characterization of gene-gene interactions along with confounding factors using the MDR 3.0.2 software. [15] The MDR multi-factor dimensionality reduction method performed well when dealing with high-order sparse data in addition to logistic regression. The best interaction model was selected on the basis of testing balance accuracy and cross-validation consistency.…”

Section: Statisticsmentioning

confidence: 99%

Association of single nucleotide polymorphisms of IL-6 gene with frailty in the Chinese Bai nationality

Li,

Yang,

Meng

et al. 2023

Medicine

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To investigate the impact of 3 single nucleotide polymorphisms (SNPs) in the interleukin-6 (IL-6) gene and their interaction on susceptibility to frailty in the elderly in rural areas of China Bai nationality. Taking the Bai people in Dali, China as the research object, and according to the frailty phenotype scale, there were 2 groups: frail and non-frail. Basic information about the study participants was gathered using a questionnaire. Clinical biochemical indices were also evaluated and the Sanger method was used to identify the sequences of the IL-6 gene loci at rs1524107, rs1800796, and rs10499563. SHEsis online software was used to analyze the linkage disequilibrium of IL-6 gene sites and the relationship between haploids and frailty. The MDR software was used to analyze the 3 sites and their interactions. Among 231 rural Bai elderly people, 63 (27.3%) were frail and 168 (72.7%) were non-frail. The SNPs of rs1524107, rs1800796, and rs10499563 in the IL-6 gene were not associated with the occurrence of frailty, nor were they associated with clinical indicators such as grip strength and gait speed. After adjusting for age and gender, there was no significant difference in the distribution of the 3 genetic models composed of the 3 SNPs between frail and non-frail populations (all P > .05). The 3 haplotypes were not associated with the occurrence of frailty, and the interaction between the 3 loci was not associated with the susceptibility to frailty. The SNP of rs1524107, rs1800796, and rs10499563 sites of IL-6 gene may not be related to frailty susceptibility in Dali Bai people. Differences in frailty mechanisms among other populations at the gene level, which are of enormous significance for the prevention and treatment of frailty, require further research with larger samples and more gene loci.

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Clinical value of echocardiography combined with serum Cav-1, NFATc1, and PAI-1 in the diagnosis of Kawasaki disease complicated with coronary artery lesions

Zhang,

Liu

2023

Heart Vessels

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Combined Genotype Effects of <b><i>TP53</i></b> and <b><i>PAI-1</i></b> Polymorphisms in Breast Cancer Susceptibility: Multifactor Dimensionality Reduction and in silico Analysis

Cited by 6 publications

References 38 publications

PAI-1 Polymorphisms Have Significant Associations With Cancer Risk, Especially Feminine Cancer

PAI-1 Polymorphisms Have Significant Associations With Cancer Risk, Especially Feminine Cancer

Association of single nucleotide polymorphisms of IL-6 gene with frailty in the Chinese Bai nationality

Clinical value of echocardiography combined with serum Cav-1, NFATc1, and PAI-1 in the diagnosis of Kawasaki disease complicated with coronary artery lesions

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