TP53 and XRCC1 polymorphisms and breast cancer prognosis: a case-case study

Rodrigues, Marina Silva; Machado, Camila Almeida; Pagnoncelli, Dante; Avvad, Elizabeth; Paixão, Julio Cesar; Gallo, C.

doi:10.1590/s1807-59322011000600030

Cited by 8 publications

(7 citation statements)

References 30 publications

(33 reference statements)

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“…Previous study showed an improved survival rate for breast cancer patients with XRCC1-399 Gln/Gln receiving chemotherapy (Bewick et al, 2009;Rodrigues et al, 2011). One study conducted in Canada reported XRCC1 Arg399Gln was an independent predictor for progression (Bewick et al, 2009), and another study showed a nonsignificant decreased risk of survival for breast cancer (Rodrigues et al, 2011). Similar results were found for the survival of non-small-cell lung cancer, colorectal cancer, gastric cancer and ovarian cancer (Khrunin et al, 2010;Engin et al, 2011;Tahara et al, 2011;Liao et al, 2012).…”

Section: Discussionmentioning

confidence: 56%

“…Several studies have found an association of XRCC1-399 with the risk of various cancers, such as breast cancer, colorectal cancer, lung cancer, thyroid carcinoma, gastric cancer and breast cancer (Engin et al, 2011;Fard-Esfahani et al, 2011;Xu et al, 2011;Raabe et al, 2012;Zhao et al, 2012). Previous study showed an improved survival rate for breast cancer patients with XRCC1-399 Gln/Gln receiving chemotherapy (Bewick et al, 2009;Rodrigues et al, 2011). One study conducted in Canada reported XRCC1 Arg399Gln was an independent predictor for progression (Bewick et al, 2009), and another study showed a nonsignificant decreased risk of survival for breast cancer (Rodrigues et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

Rong¹,

Huang²,

Zheng³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

Rong¹,

Huang²,

Zheng³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…However, the variant 194Trp/Trp genotype was previously been reported as a protective factor for gastric cancer in Chinese (Shen et al, 2000) and pancreatic cancer in US Caucasians (Jiao et al, 2006). In addition to GIC, XRCC1 Arg194Trp SNP was also associated with other cancers such as breast, lung, glioma and thyroid (Chen et al, 2002;Pachouri et al, 2007;Rodrigues et al, 2011;Du et al, 2013;Feng et al, 2014;Xu et al, 2014). This suggests that 194Trp allele in XRCC1 gene might be a core factor in altering the DNA repair mechanism and leads to several cancers development, and further investigation will be needed for this aspect.…”

Section: Discussionmentioning

confidence: 98%

Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo

Halim¹,

Chong²,

Goh³

et al. 2016

Asian Pacific Journal of Cancer Prevention

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Background: The XRCC1 protein facilitates various DNA repair pathways; single-nucleotide polymorphisms (SNPs) in this gene are associated with a risk of gastrointestinal cancer (GIC) with inconsistent results, but no data have been previously reported for the Sabah, North Borneo, population. We accordingly investigated the XRCC1 Arg194Trp and Arg399Gln SNPs in terms of GIC risk in Sabah. Materials and Methods: We performed genotyping for both SNPs for 250 GIC patients and 572 healthy volunteers using a polymerase chain reactionrestriction fragment length polymorphism approach. We validated heterozygosity and homozygosity for both SNPs using direct sequencing. Results: The presence of a variant 194Trp allele in the Arg194Trp SNP was significantly associated with a higher risk of GIC, especially with gastric and colorectal cancers. We additionally found that the variant 399Gln allele in Arg399Gln SNP was associated with a greater risk of developing gastric cancer. Our combined analysis revealed that inheritance of variant alleles in both SNPs increased the GIC risk in Sabah population. Based on our etiological analysis, we found that subjects ≥50 years and males who carrying the variant 194Trp allele, and Bajau subjects carrying the 399Gln allele had a significantly increased risk of GIC. Conclusions: Our findings suggest that inheritance of variant alleles in XRCC1 Arg194Trp and Arg399Gln SNPs may act as biomarkers for the early detection of GIC, especially for gastric and colorectal cancers in the Sabah population.

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“…Genetic factors and individual lifestyle habits could both influence the risk of breast cancer (2). Studies have shown that the risk of breast cancer is associated with a combination of factors, such as older age, early menstrual period, late or no pregnancy, starting menopause after age of 55, not being physically active, having dense breasts, being overweight, using combination hormone therapy, previous treatment using radiation therapy, personal history of breast cancer, smoking, and drinking alcohol.…”

Section: Introductionmentioning

confidence: 99%

CYP1A1 Gene Polymorphism and Breast Cancer

Balkhi

Mashayekhi

2017

Ann Mil Health Sci Res

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Objectives: Estrogen is one of the important factors in the progression of breast cancer. Cytochrome P450 Superfamily (CYPs) plays an important role in the metabolism of estrogen. The CYP1A1 gene has been shown to be involved in the metabolism of estradiol. Several studies have reported a significant association between CYP1A1 polymorphisms and breast cancer. Methods:In the present work, the association between CYP1A1 polymorphism (Thr461Asn) and breast cancer in Guilan province was investigated. The blood samples were obtained from 120 patients and 80 controls. After DNA extraction, specific primers were adapted to amplify the specific fragment using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) and the results were examined through gel-electrophoresis. The product of amplification was digested with restriction enzyme BsmA1.Results: Genotype distributions of the CYP1A1 gene showed no significant difference between patients and controls (P = 0.12, Allele A in patients 0.16, in controls 0.10, Allele C in patients 0.84, and controls 0.9, respectively). Conclusions:The results from this study suggest that the Thr461Asn polymorphism of CYP1A1 gene may not be associated with the risk of breast cancer in the population of Guilan province. Further studies are needed to confirm the role of CYP1A1 gene in breast cancer.

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TP53 and XRCC1 polymorphisms and breast cancer prognosis: a case-case study

Cited by 8 publications

References 30 publications

XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

XRCC1 and ADPRT Polymorphisms Associated with Survival in Breast Cancer Cases Treated with Chemotherapy

Variant Alleles in XRCC1 Arg194Trp and Arg399Gln Polymorphisms Increase Risk of Gastrointestinal Cancer in Sabah, North Borneo

CYP1A1 Gene Polymorphism and Breast Cancer

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