Tp‐e Interval, Tp‐e/QTc Ratio, and Fragmented QRS Are Correlated with the Severity of Liver Cirrhosis

Akboğa, Mehmet Kadri; Yüksel, Mahmut; Balcı, Kevser Gülcihan; Kaplan, Mustafa; Çay, Serkan; Gökbulut, Volkan; Yayla, Çağrı; Ertem, Ahmet Göktuğ; Ayhan, Meral Akdoğan; Topaloğlu, Serkan; Aras, Dursun

doi:10.1111/anec.12359

Cited by 8 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, it was shown that total (transmural, apicobasal and global) dispersion of repolarization could be represented by the interval between the peak and the end of T wave on ECG (Tp–e interval) ( 9 , 10 ). Moreover, both Tp–e interval and Tp–e/corrected QT (QTc) ratio were described to detect ventricular repolarization abnormalities in various diseases ( 11 – 13 ).…”

Section: Introductionmentioning

confidence: 99%

Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy

Akboğa

Balcı²,

Yılmaz³

et al. 2017

Anatol J Cardiol

Self Cite

View full text Add to dashboard Cite

Objective:Hypertrophic cardiomyopathy (HCM) as a common genetic heart disease characterized by ventricular hypertrophy and myocardial fibrosis is significantly associated with a higher risk of fatal ventricular arrhythmic events (VAEs). We aimed to assess the interval between the peak and the end of the electrocardiographic T wave (Tp–e) and Tp–e/corrected QT (QTc) ratio as candidate markers of ventricular arrhythmias in patients with HCM.Methods:In this single-center, prospective study, a total of 66 patients with HCM and 88 controls were enrolled. The patients were divided into two groups: those with VAEs (n=26) and those without VAEs (n=40). Tp–e interval and Tp–e/QTc ratio were measured using a 12-lead electrocardiogram.Results:Tp–e interval was significantly longer and Tp–e/QTc ratio were significantly higher in HCM patients than in the controls. In correlation analysis, maximal left ventricular (LV) thickness also has a significant positive correlation with Tp–e interval (r=0.422, p<0.001) and Tp–e/QTc ratio (r=0.348, p<0.001). Finally, multivariable regression analysis showed that a history of syncope, Tp–e interval [OR (odds ratio): 1.060; 95% confidence interval (CI): 1.005–1.117); p=0.012], Tp–e/QTc ratio (OR:1.148; 95%CI:1.086–1.204); p=0.049], and maximal LV thickness were independent predictors of VAEs in patients with HCM.Conclusion:Our findings suggested that prolonged Tp–e interval and increased Tp–e/QTc ratio may be good surrogate markers for the prediction of VAEs in HCM.

show abstract

Section: Introductionmentioning

confidence: 99%

Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy

Akboğa

Balcı²,

Yılmaz³

et al. 2017

Anatol J Cardiol

Self Cite

View full text Add to dashboard Cite

show abstract

“…The result agrees with earlier findings, but also is in contrast with some other findings. [24][25] The disagreement could be due to the difference in sample sizes, and also because there is no universally accepted definition of cirrhotic cardiomyopathy. Also, there are many different instruments to assess the condition, and studies adopt different inclusion criteria.…”

Section: Discussionmentioning

confidence: 99%

Do you have to evaluate the heart of the cirrhotic patients?

Mohammed Hussien Ahmed,

Mohammed Said Radwan,

Ibrahim Fathi Amer

et al. 2023

J Pak Med Assoc

View full text Add to dashboard Cite

Objective: To identify patients with occult cardiac dysfunction and its relationship with the severity of liver impairment.Method: This is a Judgment (Purposive) Sampling, cross-sectional study that was conducted at Kafrelsheikh University Hospital, Egypt, from November 2019 to December 2020, and comprised adult patients of either gender with liver cirrhosis. After detailed history, a clinical examination, pathological assessment and cardiac evaluation based on electrocardiogram and echocardiography, the patients were divided into three groups. Patients who had dyspnoea or cyanosis were in group A, those who did not have dyspnoea or cyanosis but had electrocardiogram and echocardiography abnormalities were in group B, and patients who did not have dyspnoea, cyanosis or electrocardiogram and echocardiography abnormalities were in group C. The severity of the liver disease wasevaluated using Child-Pugh and Model of End Liver Disease scores. Data was analysed using SPSS 20.Results: Of the 300 patients, 153(51%) were males and 147(49%) were females. The overall mean age was 55.1±5.1 years (range: 20-60 years). There were 58(19.33%) patients in group A, 108(36%) in group B and 134(44.66%) in group C. Group A patients showed higher Child-Pugh and Model of End Liver Disease scores than the other groups (p<0.05). Child-Pugh score >6 and Model of End Liver Disease score >37 yielded the best accuracy for detecting cardiac abnormalities in group B (p<0.05).Conclusion: There were significant cardiac changes in cirrhotic patients.Keywords: Liver cirrhosis, Electrocardiography, Cirrhotic cardiomyopathy, Hyperdynamic circulation

show abstract

“…Tp‐e interval has been investigated in many diseases in which are the incidence of sudden cardiac death and malign ventricular arrhythmias increase. Some of them are HIV patients, patients with liver cirrhosis, patients with celiac disease, migraine attacks, patients with vasospastic angina, and arrhythmogenic right ventricular cardiomyopathy, smokers and many other diseases 17‐19,36‐40 …”

Section: Discussionmentioning

confidence: 99%

Variation of Tpeak‐end, corrected Tpeak‐end, QT, and corrected QT intervals, Tpeak‐end/QT, Tpeak‐end/corrected QT ratios and heart rate variability according to decades in the healthy male subjects aged between 30 and 79 years

Cosgun

Oren

2020

Journal of Arrhythmia

View full text Add to dashboard Cite

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. AbstractBackground: Heart rate variability (HRV) is a predictor of cardiac autonomic functions. Ventricular repolarization markers can indicate ventricular arrhythmias. We aimed to evaluate variations of HRV and these repolarization markers in five healthy male groups between age 30 and 79 years according to decades. Materials and Methods:The study group consisted of 500 healthy male subjects between October 2018 and May 2019. The male subjects were divided into five categories according to their ages. Then, electrocardiograms (ECG), transthoracic echocardiograms (TTE), and treadmill exercise test (TET) were performed. T-wave peak-end (Tp-e) interval was defined as the time between the peak point and end of T-wave. Tp-e, corrected Tp-e (cTp-e), QT, and corrected QT (QTc) were measured from the resting ECGs and HRV temporal parameters (SDNN, SDNN Index, SDANN Index, RMSSD, sNN50, and pNN50), and HRV frequency parameters (VLF, LF, HF, and LF/HF) were obtained from 24-hour Holter monitorization recordings. One-way ANOVA test was used for the differences between the groups. Pearson correlation test was used to determine the correlations between the values of all groups. Results:Considering the repolarization parameters, there are significant differences in five groups in terms of Tp-e interval, but not Tp-e/QT and Tp-e/QTc ratios.Considering the HRV parameters, there were statistically significant differences between the five male healthy groups in terms of HRV temporal parameters and there are no significant differences in terms of HRV frequency parameters. Conclusion:As the age increases, basal Tp-e interval increases and HRV temporal parameters decrease significantly in the male subjects aged between 30 and 79 years, but HRV frequency parameters do not change. K E Y W O R D Shealthy male subjects, heart rate variability, Tp-e interval, Tp-e/QT ratio, Tp-e/QTc ratio, variation according to decades | 509 COSGUN aNd OREN

show abstract

Tp‐e Interval, Tp‐e/QTc Ratio, and Fragmented QRS Are Correlated with the Severity of Liver Cirrhosis

Abstract: Our study demonstrated that Tp-e interval, Tp-e/QTc ratios, and fQRS rates were significantly increased in parallel to the severity of LC. Thus, these findings may implicate that Tp-e interval, Tp-e/QTc ratio, and fQRS may be novel and useful indicators for prediction of arrhythmias in LC.

Cited by 8 publications

References 30 publications

Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy

Tp-e interval and Tp-e/QTc ratio as novel surrogate markers for prediction of ventricular arrhythmic events in hypertrophic cardiomyopathy

Do you have to evaluate the heart of the cirrhotic patients?

Variation of Tpeak‐end, corrected Tpeak‐end, QT, and corrected QT intervals, Tpeak‐end/QT, Tpeak‐end/corrected QT ratios and heart rate variability according to decades in the healthy male subjects aged between 30 and 79 years

Contact Info

Product

Resources

About