Toyo virus, a novel member of the Kaisodi group in the genus Uukuvirus (family Phenuiviridae) found in Haemaphysalis formosensis ticks in Japan

Kobayashi, Daisuke; Kuwata, Ryusei; Kimura, Toshiya; Faizah, Astri Nur; Higa, Yukiko; Hayashi, Toshihiko; Sawabe, Kyoko; Isawa, Haruhiko

doi:10.1007/s00705-021-05193-w

Cited by 9 publications

(7 citation statements)

References 46 publications

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“…S2 to S4). QDTUV (H01 and H04 to H06) was clustered with Toyo virus reported in Japan in 2021 ( 23 ), showing nucleotide identities of 77.88% to 78.29%, 72.48% to 78.70%, and 45.79% to 46.09% with the L, M, and S segments of Toyo virus (GenBank accession numbers LC618931.1 to LC618933.1 ), respectively, and amino acid identities of 90.05% to 91.29%, 81.04% to 81.48%, 85.14% to 86.28%, and 72.68% to 73.0% with RdRp, G, N, and Ns (GenBank accession numbers BCT55140.1 to BCT55143.1 ), respectively ( Table 3 ; Fig. S5 to S7).…”

Section: Resultsmentioning

confidence: 79%

Diversity Analysis of Tick-Borne Viruses from Hedgehogs and Hares in Qingdao, China

Jiang

Luo

et al. 2023

Microbiol Spectr

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Thirty-six strains of 10 RNA viruses belonging to 4 viral families, including 3 viruses of Iflaviridae , 4 viruses of Phenuiviridae , 2 viruses of Nairoviridae , and 1 virus of Chuviridae , were identified from five tick species in Qingdao, China. A diversity of tick-borne viruses from hares and hedgehogs in Qingdao was found in this study.

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Section: Resultsmentioning

confidence: 79%

Diversity Analysis of Tick-Borne Viruses from Hedgehogs and Hares in Qingdao, China

Jiang

Luo

et al. 2023

Microbiol Spectr

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“…Lihan virus [26], Pacific coast tick virus [4], Tacheng tick virus 2 [26], Rukutama virus [29], Silverwater virus [31], Yongjia virus 1 [26], and Toyo virus, a new member of this genus [20]. Some species of the genus can infect humans and animals, since anti-Uukuvirus antibodies have been detected in sera from humans [14,28], cows, and reptiles [14].…”

Section: Tick-borne Viruses (Tbvs) Belong To Two Orders (Bunyavirales...mentioning

confidence: 99%

“…All VN-positive sera were positive by IFA using infected cells, confirming that VN-positive animals indeed were infected with KAMV or a KAMV-like virus. In Japan, novel uukuviruses, Toyo virus and Okutama tick virus were recently discovered [19,20]. In addition, fifteen wild boars possessed relatively high VN titers of 1:80 or more.…”

Section: Kamv a New Member Of The Tick-borne Phleboviruses Was Isolat...mentioning

confidence: 99%

Epidemiological study of Kabuto Mountain virus, a novel uukuvirus, in Japan

et al. 2022

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Kabuto Mountain virus (KAMV), the new member of the genus Uukuvirus, was isolated from the tick Haemaphysalis flava in 2018 in Japan. To date, there is no information on KAMV infection in human and animals. Therefore, serological surveillance of the infection among humans and wild mammals was conducted by virus-neutralization (VN) test and indirect immunofluorescence assay (IFA). Sera of 24 humans, 59 monkeys, 171 wild boars, 233 Sika deer, 7 bears, and 27 nutria in Yamaguchi Prefecture were analyzed by VN test. The positive ratio of humans, monkeys, wild boars, and Sika deer were 20.8 %, 3.4 %, 33.9 % and 4.7 %, respectively.No positive samples were detected in bears and nutria. The correlation coefficients between VN test and IFA in human, monkey, wild boar, and Sika deer sera were 0.5745, 0.7198, 0.9967 and 0.9525, respectively. In addition, KAMV was detected in one pool of Haemaphysalis formosensis ticks in Wakayama Prefecture. These results indicated that KAMV or KAMV-like virus is circulating among many wildlife and ticks, and that this virus incidentally infects humans.

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“…The significance of tick-borne viral diseases (TBVDs) in human health has raised global health concerns in recent decades due to current suboptimal diagnostics, treatment options for emerging viruses, and a scarcity of vaccines (7). Attention from clinicians and researchers had alerted the public to the frequent emergences of novel viral pathogens causing febrile human diseases, such as Dabie bandavirus, also known as severe fever with thrombocytopenia syndrome virus (SFTSV) (8,9), Alongshan virus (10), Bourbon virus (11), most recently Jingmen tick virus (12), Yezo virus (13), Toyo virus (14), and Songlin virus (15), which had been identified in China and neighboring countries. In addition, the re-emergence and continuous spread of known tick-borne viral diseases (TBVDs), such as Crimean-Congo hemorrhagic fever virus (CCHFV) (16), Heartland virus (17), tick-borne encephalitis virus (18), Powassan virus (19), and African swine fever virus (20), positively correlate with the increasing incidence of TBVDs in humans and animals.…”

Section: Introductionmentioning

confidence: 99%

Diversity of RNA viruses of three dominant tick species in North China

et al. 2023

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BackgroundA wide range of bacterial pathogens have been identified in ticks, yet the diversity of viruses in ticks is largely unexplored.MethodsHere, we used metagenomic sequencing to characterize the diverse viromes in three principal tick species associated with pathogens, Haemaphysalis concinna, Dermacentor silvarum, and Ixodes persulcatus, in North China.ResultsA total of 28 RNA viruses were identified and belonged to more than 12 viral families, including single-stranded positive-sense RNA viruses (Flaviviridae, Picornaviridae, Luteoviridae, Solemoviridae, and Tetraviridae), negative-sense RNA viruses (Mononegavirales, Bunyavirales, and others) and double-stranded RNA viruses (Totiviridae and Partitiviridae). Of these, Dermacentor pestivirus-likevirus, Chimay-like rhabdovirus, taiga tick nigecruvirus, and Mukawa virus are presented as novel viral species, while Nuomin virus, Scapularis ixovirus, Sara tick-borne phlebovirus, Tacheng uukuvirus, and Beiji orthonairovirus had been established as human pathogens with undetermined natural circulation and pathogenicity. Other viruses include Norway mononegavirus 1, Jilin partitivirus, tick-borne tetravirus, Pico-like virus, Luteo-like virus 2, Luteo-likevirus 3, Vovk virus, Levivirus, Toti-like virus, and Solemo-like virus as well as others with unknown pathogenicity to humans and wild animals.ConclusionIn conclusion, extensive virus diversity frequently occurs in Mononegavirales and Bunyavirales among the three tick species. Comparatively, I. persulcatus ticks had been demonstrated as such a kind of host with a significantly higher diversity of viral species than those of H. concinna and D. silvarum ticks. Our analysis supported that ticks are reservoirs for a wide range of viruses and suggested that the discovery and characterization of tick-borne viruses would have implications for viral taxonomy and provide insights into tick-transmitted viral zoonotic diseases.

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Toyo virus, a novel member of the Kaisodi group in the genus Uukuvirus (family Phenuiviridae) found in Haemaphysalis formosensis ticks in Japan

Cited by 9 publications

References 46 publications

Diversity Analysis of Tick-Borne Viruses from Hedgehogs and Hares in Qingdao, China

Diversity Analysis of Tick-Borne Viruses from Hedgehogs and Hares in Qingdao, China

Epidemiological study of Kabuto Mountain virus, a novel uukuvirus, in Japan

Diversity of RNA viruses of three dominant tick species in North China

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