Diversity of RNA viruses of three dominant tick species in North China

Qin, Tong; Shi, Mingjie; Zhang, Meina; Liu, Zhitong; Feng, Hao; Sun, Yi

doi:10.3389/fvets.2022.1057977

Cited by 6 publications

(4 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most abundant viral order recovered in our data, the Monogenavirales, are a large group of nonsegmented, enveloped viruses currently classified into 11 families and infecting a broad diversity of plants, animals, humans, and frequently reported from metatranscriptomic tick surveys [37,56,57]. All nine tick genomes analyzed here contained EVEs of mononegavirus provenance (n = 208), with a majority from the family Rhabdoviridae (n = 186; 89.4%).…”

Section: Mononegavirales (-Ssrna)mentioning

confidence: 82%

Endogenous Viral Elements in Ixodid Tick Genomes

Barnes,

Price

2023

Viruses

View full text Add to dashboard Cite

The documentation of endogenous viral elements (EVEs; virus-derived genetic material integrated into the genome of a nonviral host) has offered insights into how arthropods respond to viral infection via RNA interference pathways. Small non-coding RNAs derived from EVE loci serve to direct RNAi pathways in limiting replication and infection from cognate viruses, thus benefiting the host’s fitness and, potentially, vectorial capacity. Here we use informatic approaches to analyze nine available genome sequences of hard ticks (Acari: Ixodidae; Rhipicephalus sanguineus, R. microplus, R. annulatus, Ixodes ricinus, I. persulcatus, I. scapularis, Hyalomma asiaticum, Haemaphysalis longicornis, and Dermacentor silvarum) to identify endogenous viral elements and to illustrate the shared ancestry of all elements identified. Our results highlight a broad diversity of viral taxa as having given rise to 1234 identified EVEs in ticks, with Mononegavirales (specifically Rhabdoviridae) well-represented in this subset of hard ticks. Further investigation revealed extensive adintovirus integrations in several Ixodes species, the prevalence of Bunyavirales EVEs (notably not observed in mosquitoes), and the presence of several elements similar to known emerging human and veterinary pathogens. These results will inform subsequent work on current and past associations with tick species with regard to the viruses from which their “viral fossils” are derived and may serve as a reference for quality control of various tick-omics data that may suffer from misidentification of EVEs as viral genetic material.

show abstract

Section: Mononegavirales (-Ssrna)mentioning

confidence: 82%

Endogenous Viral Elements in Ixodid Tick Genomes

Barnes,

Price

2023

Viruses

View full text Add to dashboard Cite

show abstract

“…It is genetically related to SFTSV and Heartland virus by phylogenetic analyses and may have a similar RNA replication mechanism to SFTSV ( Shen et al, 2018 ). Mukawa virus (MKWV) was first detected in I. persulcatus in Japan in 2018, and researchers found that I. persulcatus and H. concinna in Heilongjiang Province carried MKWV and were capable of infecting mammals, but it had not yet been reported in other countries or regions ( Wang et al, 2022 ; Qin et al, 2023 ). It was curious that MKWV was not genetically similar to any other tick-borne Phenuiviridae viruses on the phylogenetic tree, instead, it was related to viruses transmitted by mosquitoes and sandflies ( Matsuno et al, 2018 ).…”

Section: Resultsmentioning

confidence: 99%

“…As another member of the genus Bandavirus, GTV is a new tick-borne Bandavirus detected in 2018 from D. nuttalli and human serum samples in XUAR. It is genetically related to SFTSV and Heartland virus by phylogenetic analyses and may have a similar RNA replication mechanism to SFTSV (Shen et al, 10.3389/fmicb.2024.1309698 Frontiers in Microbiology 04 frontiersin.org (Wang et al, 2022;Qin et al, 2023). It was curious that MKWV was not genetically similar to any other tick-borne Phenuiviridae viruses on the phylogenetic tree, instead, it was related to viruses transmitted by mosquitoes and sandflies (Matsuno et al, 2018).…”

Section: Phenuiviridaementioning

confidence: 99%

Diversity of species and geographic distribution of tick-borne viruses in China

Wu,

Zhou,

Mao

et al. 2024

Front. Microbiol.

View full text Add to dashboard Cite

IntroductionTick-borne pathogens especially viruses are continuously appearing worldwide, which have caused severe public health threats. Understanding the species, distribution and epidemiological trends of tick-borne viruses (TBVs) is essential for disease surveillance and control.MethodsIn this study, the data on TBVs and the distribution of ticks in China were collected from databases and literature. The geographic distribution of TBVs in China was mapped based on geographic locations of viruses where they were prevalent or they were detected in vector ticks. TBVs sequences were collected from The National Center for Biotechnology Information and used to structure the phylogenetic tree.ResultsEighteen TBVs from eight genera of five families were prevalent in China. Five genera of ticks played an important role in the transmission of TBVs in China. According to phylogenetic analysis, some new viral genotypes, such as the Dabieshan tick virus (DTV) strain detected in Liaoning Province and the JMTV strain detected in Heilongjiang Province existed in China.DiscussionTBVs were widely distributed but the specific ranges of viruses from different families still varied in China. Seven TBVs belonging to the genus Orthonairovirus of the family Nairoviridae such as Nairobi sheep disease virus (NSDV) clustered in the Xinjiang Uygur Autonomous Region (XUAR) and northeastern areas of China. All viruses of the family Phenuiviridae except Severe fever with thrombocytopenia syndrome virus (SFTSV) were novel viruses that appeared in the last few years, such as Guertu virus (GTV) and Tacheng tick virus 2 (TcTV-2). They were mainly distributed in the central plains of China. Jingmen tick virus (JMTV) was distributed in at least fourteen provinces and had been detected in more than ten species of tick such as Rhipicephalus microplus and Haemaphysalis longicornis, which had the widest distribution and the largest number of vector ticks among all TBVs. Parainfluenza virus 5 (PIV5) and Lymphatic choriomeningitis virus (LCMV) were two potential TBVs in Northeast China that could cause serious diseases in humans or animals. Ixodes persulcatus carried the highest number of TBVs, followed by Dermacentor nuttalli and H. longicornis. They could carry as many as ten TBVs. Three strains of Tick-borne encephalitis (TBEV) from Inner Mongolia Province clustered with ones from Russia, Japan and Heilongjiang Province, respectively. Several SFTSV strains from Zhejiang Province clustered with strains from Korea and Japan. Specific surveillance of dominant TBVs should be established in different areas in China.

show abstract

“…Furthermore, I. persulcatus has been identified as a carrier of viruses from at least seven different virus families, including Peribunyaviridae , Nairoviridae , Orthomyxoviridae , Phenuiviridae , Reoviridae , Flaviviridae , and Phenuiviridae [ 4 , 5 ]. Some of these viruses, such as TBEV and Powassan virus (POWV), are closely associated with human diseases.…”

Section: Introductionmentioning

confidence: 99%

Metatranscriptomics Reveals the RNA Virome of Ixodes Persulcatus in the China–North Korea Border, 2017

Wang,

Liu,

Sun

et al. 2023

Viruses

View full text Add to dashboard Cite

In recent years, numerous viruses have been identified from ticks, and some have been linked to clinical cases of emerging tick-borne diseases. Chinese northeast frontier is tick infested. However, there is a notable lack of systematic monitoring efforts to assess the viral composition in the area, leaving the ecological landscape of viruses carried by ticks not clear enough. Between April and June 2017, 7101 ticks were collected to perform virus surveillance on the China–North Korea border, specifically in Tonghua, Baishan, and Yanbian. A total of 2127 Ixodes persulcatus were identified. Further investigation revealed the diversity of tick-borne viruses by transcriptome sequencing of Ixodes persulcatus. All ticks tested negative for tick-borne encephalitis virus. Transcriptome sequencing expanded 121 genomic sequence data of 12 different virus species from Ixodes persulcatus. Notably, a new segmented flavivirus, named Baishan Forest Tick Virus, were identified, closely related to Alongshan virus and Harz mountain virus. Therefore, this new virus may pose a potential threat to humans. Furthermore, the study revealed the existence of seven emerging tick-borne viruses dating back to 2017. These previously identified viruses included Mudanjiang phlebovirus, Onega tick phlebovirus, Sara tick phlebovirus, Yichun mivirus, and three unnamed viruses (one belonging to the Peribunyaviridae family and the other two belonging to the Phenuiviridae family). The existence of these emerging tick-borne viruses in tick samples collected in 2017 suggests that their history may extend further than previously recognized. This study provides invaluable insights into the virome of Ixodes persulcatus in the China–North Korea border region, enhancing our ongoing efforts to manage the risks associated with tick-borne viruses.

show abstract

Diversity of RNA viruses of three dominant tick species in North China

Cited by 6 publications

References 68 publications

Endogenous Viral Elements in Ixodid Tick Genomes

Endogenous Viral Elements in Ixodid Tick Genomes

Diversity of species and geographic distribution of tick-borne viruses in China

Metatranscriptomics Reveals the RNA Virome of Ixodes Persulcatus in the China–North Korea Border, 2017

Contact Info

Product

Resources

About