TOXsIgN: a cross-species repository for toxicogenomic signatures

Darde, Thomas Alain; Gaudriault, Pierre; Béranger, Rémi; Lancien, Clément; Caillarec-Joly, Annaelle; Sallou, Olivier; Bonvallot, Nathalie; Chevrier, Cécile; Mazaud-Guittot, Séverine; Jégou, Bernard; Collin, Olivier; Becker, E.; Rolland, Antoine; Chalmel, Frédéric

doi:10.1093/bioinformatics/bty040

Cited by 23 publications

(10 citation statements)

References 41 publications

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“…Data were uploaded to the NCBI Gene Expression Omnibus (GEO) repository under the accession number GSE117527 [ 50 ]. Lists of genes significantly induced or repressed after B[ α ]P exposure were also uploaded to the TOXsIgN repository under the accession TSP758 [ 51 ].…”

Section: Methodsmentioning

confidence: 99%

Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene

Liamin

Mentec

Evrard

et al. 2018

IJMS

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Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental contaminants, known to affect T lymphocytes. However, the molecular targets and pathways involved in their immunotoxic effects in human T lymphocytes remain unknown. Here, we analyzed the gene expression profile of primary human T lymphocytes treated with the prototypical PAH, benzo[α]pyrene (B[α]P), using a microarray-based transcriptome analysis. After a 48 h exposure to B[α]P, we identified 158 genes differentially expressed in T lymphocytes, including not only genes well-known to be affected by PAHs such as the cytochromes P450 (CYP) 1A1 and 1B1, but also others not previously shown to be targeted by B[α]P such as genes encoding the gap junction beta (GJB)-2 and 6 proteins. Functional enrichment analysis revealed that these candidates were significantly associated with the aryl hydrocarbon (AhR) and interferon (IFN) signaling pathways; a marked alteration in T lymphocyte recruitment was also observed. Using functional tests in transwell migration experiments, B[α]P was then shown to significantly decrease the chemokine (C-X-C motif) ligand 12-induced chemotaxis and transendothelial migration of T lymphocytes. In total, this study opens the way to unsuspected responsive pathway of interest, i.e., T lymphocyte migration, thus providing a more thorough understanding of the molecular basis of the immunotoxicity of PAHs.

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Section: Methodsmentioning

confidence: 99%

Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene

Liamin

Mentec

Evrard

et al. 2018

IJMS

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“…Together, the outcomes of the human and animal studies will provide toxicity signatures for EDC-associated female reproductive toxicity. These toxicity signatures will be made publicly available in the TOXsIgN database [38] and can be used as scientific basis for the development of a strategy to address female reproductive toxicity.…”

Section: Advancing Test Methods For Edc Identification In Chemical Rementioning

confidence: 99%

Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

Duursen

Boberg

Christiansen

et al. 2020

IJMS

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Currently available test methods are not well-suited for the identification of chemicals that disturb hormonal processes involved in female reproductive development and function. This renders women’s reproductive health at increasing risk globally, which, coupled with increasing incidence rates of reproductive disorders, is of great concern. A woman’s reproductive health is largely established during embryonic and fetal development and subsequently matures during puberty. The endocrine system influences development, maturation, and function of the female reproductive system, thereby making appropriate hormone levels imperative for correct functioning of reproductive processes. It is concerning that the effects of human-made chemicals on the endocrine system and female reproductive health are poorly addressed in regulatory chemical safety assessment, partly because adequate test methods are lacking. Our EU-funded project FREIA aims to address this need by increasing understanding of how endocrine disrupting chemicals (EDCs) can impact female reproductive health. We will use this information to provide better test methods that enable fit-for-purpose chemical regulation and then share our knowledge, promote a sustainable society, and improve the reproductive health of women globally.

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“…Raw data and transcriptomic signatures were uploaded to the NCBI Gene Expression Omnibus (GEO) (Barrett et al, 2013), to the TOXsIgN (Darde et al, 2018) and to Mendeley-Data repositories under the accession numbers GSE122494, TSP765 and doi:10.17632/bbtmz7wp4v.1, respectively.…”

Section: Data and Software Availabilitymentioning

confidence: 99%

Distinct Transcriptional Profiles of the Female, Male, and Finasteride-Induced Feminized Male Anogenital Region in Rat Fetuses

Schwartz

Vinggaard

Christiansen

et al. 2019

Toxicological Sciences

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TOXsIgN: a cross-species repository for toxicogenomic signatures

Abstract: Supplementary data are available at Bioinformatics online.

Cited by 23 publications

References 41 publications

Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene

Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene

Safeguarding Female Reproductive Health Against Endocrine Disrupting Chemicals—The FREIA Project

Distinct Transcriptional Profiles of the Female, Male, and Finasteride-Induced Feminized Male Anogenital Region in Rat Fetuses

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