Toxoplasma gondii infection modulate systemic allergic immune response in BALB/c mice

Fenoy, Ignacio Martín; Sánchez, Vanesa Roxana; Soto, Ariadna Soledad; Picchio, Mariano S.; Martin, Valentina; Goldman, Alejandra

doi:10.1016/j.exppara.2015.04.001

Cited by 12 publications

(19 citation statements)

References 19 publications

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“…have shown that T . gondii infection reduced the airway inflammation in a mouse model of OVA-induced allergy 25 , 36 . In the present study we tested immunomodulatory properties of an extract derived from T .…”

Section: Discussionmentioning

confidence: 99%

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Toxoplasma gondii tachyzoite-extract acts as a potent immunomodulator against allergic sensitization and airway inflammation

Drinić

Wagner

Sarate

et al. 2017

Sci Rep

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Epidemiological and experimental studies have shown an inverse relationship between infections with certain parasites and a reduced incidence of allergic diseases. We and others have shown that infection with Toxoplasma gondii prevents the development of allergy in mice. To establish whether this beneficial effect could be recapitulated by soluble products of this parasite, we tested an extract derived from T. gondii tachyzoites. Immunization of BALB/c mice with tachyzoites lysate antigen (TLA) elicited mixed Th1/Th2 responses. When TLA was applied together with the sensitizing ovalbumin (OVA), the development of allergic airway inflammation was reduced, with decreased airway hyperresponsiveness associated with reduced peribronchial and perivascular cellular infiltration, reduced production of OVA-specific Th2 cytokines in lungs and spleens and reduced levels of serum OVA-specific IgG1 as well as IgE-dependent basophil degranulation. Of note, TLA retained its immunomodulatory properties, inducing high levels of IL-6, TNFα, IL-10 and IL-12p70 in bone marrow-derived dendritic cells after heat-inactivation or proteinase K-treatment for disruption of proteins, but not after sodium metaperiodate-treatment that degrades carbohydrate structures, suggesting that carbohydrates may play a role in immunomodulatory properties of TLA. Here we show that extracts derived from parasites may replicate the benefits of parasitic infection, offering new therapies for immune-mediated disorders.

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Section: Discussionmentioning

confidence: 99%

“…Similar effect was observed previously in allergic mice with T . gondii infection 24 , 36 . Although high levels of IFNγ has been associated with exacerbated symptoms of asthma in humans and mice 41 , the importance of this cytokine in allergy prevention was demonstrated for example in the study by Brand et al .…”

Section: Discussionmentioning

confidence: 99%

Toxoplasma gondii tachyzoite-extract acts as a potent immunomodulator against allergic sensitization and airway inflammation

Drinić

Wagner

Sarate

et al. 2017

Sci Rep

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“…118 Another protozoan parasite, T. gondii, has been extensively studied with respect to allergic sensitization in both murine models and humans. 42,103,[120][121][122][123][124] Inverse associations have been observed in Brazilian populations between seropositivity for T. gondii and atopy (measured as both SPT and serum IgE to aeroallergens). 42,123 Although the mechanism whereby this modulation occurs is not well understood, data from murine models have shown that allergic inflammation can be suppressed by treating animals with Toxoplasma extract or derived proteins.…”

Section: Protozoa and Allergy In B R A Zilmentioning

confidence: 99%

“…Another protozoan parasite, T. gondii , has been extensively studied with respect to allergic sensitization in both murine models and humans . Inverse associations have been observed in Brazilian populations between seropositivity for T. gondii and atopy (measured as both SPT and serum IgE to aeroallergens) .…”

Section: Protozoa and Allergy In Brazilmentioning

confidence: 99%

Parasites and allergy: Observations from Brazil

Andrade

Carneiro

Cerqueira

et al. 2018

Parasite Immunology

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Brazil is a middle-income country undergoing the epidemiological transition. Effects of changes in daily life habits and access to clean water, sanitation and urban services on a growing urban population have contributed to a double burden of both infectious and noncommunicable chronic diseases. Studies have indicated that parasite infections may modulate the human immune system and influence the development of allergic conditions such as asthma. However, there is no consensus in the published literature on the effects of parasitic infections on allergy, perhaps as a consequence of factors determining the epidemiology of these infections that vary between populations such as age of first infection, duration and chronicity of infections, parasite burden and species, and host genetic susceptibility. In this review, we discuss the observations from Brazil concerning the relationship between parasite infections and allergy.

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“…Also, some parasitic infections play several significant roles in the formation and worsening of autoimmune diseases. For example, the traces of toxoplasmosis have been noticed in many autoimmune diseases, such as autoimmune thyroid disease, systemic sclerosis, rheumatoid arthritis, and discoid lupus erythematosus (5)(6)(7). It seems that parasite and host antigens' high resemblance can cause autoimmune disorders by a parasitic infection (7).…”

Section: Introductionmentioning

confidence: 99%

The Role of Toxoplasma gondii Infection Among Multiple Sclerosis Patient Compared to Ordinary People in South of Iran: A Case-Control Study

et al. 2020

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Background: Toxoplasmosis is a common parasitic disease, which leads to serious disease symptoms in immunocompromised hosts and infants. Recent epidemiologic surveys showed that microbial agents may be associated with some cases of multiple sclerosis (MS). Objectives: This case-control study aimed to examine the role of Toxoplasma gondii in MS by evaluating sero-frequency of anti-T. gondii IgG (ATXAb) antibody between patients with MS and ordinary people in Shiraz Province, south of Iran during 2016 - 2018. Methods: Serum samples obtained from MS patients (n = 130), and a group of age and gender-matched controls (n = 130) with the same socioeconomic status with the patients’ group were collected to evaluate the prevalence of T. gondii IgG antibodies (ATXAb). Moreover, the presence of the ATXAb antibody of the patients and controls was determined by the ELISA test. SPSS 20 software was used to perform the statistical analysis (SPSS, inc., Chicago, USA). Results: Out of 130 (35.4%) cases with MS and 130 (13.8%) controls, 46 and 18 subjects were seropositive for ATXAb, respectively. Based on the chi-square test, a significant difference was observed in terms of the positivity rates of ATXAb between the MS patient group and the control group (P = 0.001). The mean ± standard deviation ATXAb levels in controls and MS patients were found to be 61 ± 34 and 114 ± 47 IU/mL, respectively. Also, there were statistically significant differences between the levels of these two groups (P = 0.001). Conclusions: Given the relationship between toxoplasmosis and MS, it is possible that the prevalence of MS decreases by increasing hygiene and preventing toxoplasmosis.

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Toxoplasma gondii infection modulate systemic allergic immune response in BALB/c mice

Cited by 12 publications

References 19 publications

Toxoplasma gondii tachyzoite-extract acts as a potent immunomodulator against allergic sensitization and airway inflammation

Toxoplasma gondii tachyzoite-extract acts as a potent immunomodulator against allergic sensitization and airway inflammation

Parasites and allergy: Observations from Brazil

The Role of Toxoplasma gondii Infection Among Multiple Sclerosis Patient Compared to Ordinary People in South of Iran: A Case-Control Study

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