Toxoplasma gondii infection and spontaneous abortion: A systematic review and meta-analysis

Kalantari, Narges; Gorgani-Firouzjaee, Tahmineh; Moulana, Zahra; Chehrazi, Mohammad; Ghaffari, Salman

doi:10.1016/j.micpath.2021.105070

Cited by 18 publications

(16 citation statements)

References 56 publications

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“…In the group between (15 and 45 years old), A higher prevalence was observed between (20-35) with a percentage of 65%, while the prevalence was observed between (15-19), (36-45) and the lowest percentage was 30%. The positive rates for the other age groups varied, and this was consistent with what was indicated by many researchers in different regions of the world, as the infection rate was high in the age group (20-35 years) (Kalantari et al,2021;Mostafavi et al,2012). The age of activity of women to pregnant.…”

Section: Discussionsupporting

confidence: 88%

Use molecular technique to detect toxoplasmosis in placenta and aborted fetus in women in Al-Diwaniyah province

Jasim

Hussein

2022

ijhs

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The current study included the detection of Toxoplasma gondii from aborted women from Maternity and Childhood Teaching Hospital. It drew attention to the human infection rate in order to detect the differentiation them with SAG3 gene. The samples were collected during the period from October, 2021 until the end of March 2022 in AL-Qadisyah province. Total of 100 samples (placenta and fetus) were collected and send to the laboratory of veterinary medicine AL- Qadisiyah University in order to detect women with toxoplasmosis by impression method all of are positive. The present study included a molecular method to detect surface antigen 3 (SAG3) using Nested Polymerase Chain Reaction (nPCR), the results of the nPCR for SAG3 gene showed that 18/24 (75 %) were positive in the aborted woman. the NCBI-BLAST Homology Sequence identity (%) between local T. gondii isolated from women cases that have been deposited in the NCBI under the following accession numbers (ON240954, ON240955, ON240956, ON240957, ON240958, ON240959, ON240960, ON240961, ON240962, and ON240963) and NCBI-BLAST deposited other global strains.

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Section: Discussionsupporting

confidence: 88%

Use molecular technique to detect toxoplasmosis in placenta and aborted fetus in women in Al-Diwaniyah province

Jasim

Hussein

2022

ijhs

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“…Previous studies have suggested that latent TG infection affects the course of pregnancy, thus seropositive pregnant women show a modified secondary sex ratio in newborns [ 28 , 29 , 37 , 38 , 39 ], more spontaneous abortion [ 27 , 31 , 33 , 36 ], more prolonged pregnancies [ 43 ], obesity [ 47 ] or higher weight gain in pregnancy in Rh-negative women, higher pregnancy-induced hypertension disease rate [ 40 , 50 ] and higher prevalence of autoimmune thyroiditis [ 28 , 48 , 49 ]. In addition, previous publications mentioned that acute TG infection during pregnancy is associated with miscarriage [ 27 ] or congenital malformations in fetuses [ 2 ] and reactivation of latent infection or infection with another strain could also be a cause of congenital malformations [ 6 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies from Iran [ 27 , 31 ], Mexico [ 32 ], and Yemen [ 33 ] analyzed the association between TG seroprevalence and the history of spontaneous abortion and found controversial results. While the study from Durango City, Mexico, performed on 326 women with a history of miscarriage, did not find an association between a history of miscarriage and TG seroprevalence [ 32 ], the study from Yemen, which included 420 pregnant women, showed a significant association between TG seroprevalence and the history of spontaneous abortion [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have focused on analyzing the association of latent TG infection with the history of spontaneous abortion [ 27 ], the offspring secondary sex ratio [ 28 , 29 ], pregnancy complication prevalence and newborn status [ 30 ]. The results of research regarding the impact of latent TG infection on obstetrical history with respect to the above-mentioned pregnancy complications are still controversial and the subject of research [ 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ].…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Latent Toxoplasma gondii Infection on Spontaneous Abortion History and Pregnancy Outcomes: A Large-Scale Study

et al. 2022

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Background: Toxoplasma gondii (TG), a zoonotic protozoan parasite, belongs to a group of TORCH infectious agents, which can cause severe damage to the fetus if a primary infection occurs during pregnancy. After primary infection, TG rests lifelong in human organisms causing a latent infection. Most studies have analyzed the consequences of acute, but not latent, TG infection. This study analyzed the impact of latent toxoplasmosis on spontaneous abortion history, pregnancy complication rate and neonatal outcome. Methods: IgG and IgM anti-TG antibodies were tested in 806 pregnant women who were consulted at the Timisoara Clinical Emergency Hospital between 2008 and 2010. Demographic data, obstetrical history, and data about the pregnancy complications, birth and neonate were collected for each woman and comparisons between the groups, with and without latent TG infection, were made. Results: This study did not show differences between groups regarding the history of spontaneous abortion (OR = 1.288, p = 0.333), cesarean section (OR = 1.021, p = 0.884), placental abruption (OR 0.995, p = 0.266), pregnancy-induced hypertension rate (OR 1.083, p = 0.846), secondary sex ratio (1.043, p = 0.776), 1′ APGAR score at birth (p = 0.544), gestational age at birth (p = 0.491) or birth weight (p = 0.257). Conclusions: The observed differences between the rate of pregnancy complications in the two groups of pregnant women with and without latent infection with TG, did not reach a statistical significance.

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“…It has been estimated that congenital toxoplasmosis infections occur in approximately 1 in 10,000 births in the United States, or approximately 3800 per year. Studies from France and Brazil that have provided a longer follow-up of possible cases have reported congenital infection rates up to ten times higher than the US study [22][23][24].…”

Section: What Is Known Regarding Human Infections?mentioning

confidence: 77%

The Case for Toxoplasma gondii in Psychosis and Other Human Diseases

Torrey

2021

Parasites, Pussycats and Psychosis

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Toxoplasma gondii infection and spontaneous abortion: A systematic review and meta-analysis

Cited by 18 publications

References 56 publications

Use molecular technique to detect toxoplasmosis in placenta and aborted fetus in women in Al-Diwaniyah province

Use molecular technique to detect toxoplasmosis in placenta and aborted fetus in women in Al-Diwaniyah province

The Impact of Latent Toxoplasma gondii Infection on Spontaneous Abortion History and Pregnancy Outcomes: A Large-Scale Study

The Case for Toxoplasma gondii in Psychosis and Other Human Diseases

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