Toxicology laboratory analysis and human exposure to<i>p</i>-chloroaniline

Pizon, Anthony F.; Schwartz, Anna; Shum, L.; Rittenberger, Jon C.; Lower, Darla R.; Giannoutsos, Spiros; Virji, Mohamed A.; Krasowski, Matthew D.

doi:10.1080/15563650801971390

Cited by 32 publications

(30 citation statements)

References 8 publications

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“…According to prior cases of aniline exposure, the majority of cases involved oral ingestion and inhalation through the respiratory organs [17-19]. …”

Section: Discussionmentioning

confidence: 99%

Two Cases of Methemoglobinemia Induced by the Exposure to Nitrobenzene and Aniline

Lee

Kim

Kwon

et al. 2013

Ann of Occup and Environ Med

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ObjectiveTo report two cases of methemoglobinemia induced by inhaled nitrobenzene and dermally absorbed aniline.MethodsWe have evaluated a 37-year-old male worker exposed to nitrobenzene by inhalation while conducting maintenance job of mononitrobenzene pump and a 25-year-old male worker exposed dermally to aniline while unloading.ResultsThe first case is a 37-year-old male exposed to nitrobenzene. His blood methemoglobin concentration level was initially 19.8%, and chest X-ray was normal. After oxygen therapy, the blood methemoglobin concentration level decreased to 2.1%, and the symptoms were alleviated. The second case is a 25-year-old male exposed dermally to aniline. His chest X-ray was normal, but blood methemoglobin concentration level reached maximally 46.8%. He was treated with methylene blue due to relatively high blood methemoglobin level. Gradually after the treatment, his methemoglobin concentration level was normalized to 0.8% and simultaneously symptoms were resolved.ConclusionsAfter the thorough exposure investigations and medical evaluations, we have concluded that these cases were methemoglobinemia induced by occupational exposure to nitrobenzene and aniline. We suggest that businesses which handle methemoglobinemia-causing substances control the engineering process strictly, implement periodic screening, and establish emergency patient management system.

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“…According to prior cases of aniline exposure, the majority of cases involved oral ingestion and inhalation through the respiratory organs [17-19]. …”

Section: Discussionmentioning

confidence: 99%

Two Cases of Methemoglobinemia Induced by the Exposure to Nitrobenzene and Aniline

Lee

Kim

Kwon

et al. 2013

Ann of Occup and Environ Med

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“…On the other hand, Å OH is quenched by carbonate, phosphate, and other inorganic ions present in natural water. Moreover, O 3 and KMnO 4 react selectively with electron-rich moieties [12,13]. Persulfate (PS), which forms a strong oxidizing agent (SO 4 ÀÅ ), has recently emerged as a suitable oxidant because the sulfate radical possesses a high redox potential (E 0 = 2.6 V) [14] like other oxidizing agents (the E 0 values of H 2 O 2 , KMnO 4 , and O 3 in aqueous solution are 1.78 V, 1.70 V, and 2.07 V, respectively) [15,16].…”

Section: Introductionmentioning

confidence: 98%

“…p-Chloroaniline (PCA) is a ''three-included'' material and one of the most persistent organic pollutants that can harm the ecology and human health [1]. PCA, as a toxic and recalcitrant compound, is an important environmental pollutant in industrial wastewater that must be efficiently removed through wastewater treatment [2,3]. However, PCA cannot be directly treated using conventional biological [4][5][6] or photocatalysis [7,8] technologies.…”

Section: Introductionmentioning

confidence: 99%

Degradation of p-chloroaniline by persulfate activated with ferrous sulfide ore particles

Yuan

Tao

Fan

et al. 2015

Chemical Engineering Journal

122

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“…Urinalysis revealed a urine pH of 9.0 and was otherwise unremarkable. Urine comprehensive drug screen performed using gas chromatography and mass spectrometry (GC/MS)12 showed large spikes corresponding to topiramate (retention time 19.9 minutes) and ibuprofen. A smaller peak (retention time 20.9 minutes) was identified by its fragmentation spectrum in the GC/MS library as 10-hydroxytopiramate.…”

Section: Case Reportmentioning

confidence: 99%

Clinical Effects and Toxicokinetic Evaluation Following Massive Topiramate Ingestion

et al. 2010

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Background Topiramate is used to treat a variety of neurologic and psychiatric diseases due to its benign safety profile. Data regarding the toxicity and toxicokinetics of topiramate in acute overdose are limited. A case of massive, acute ingestion resulting in the highest reported topiramate level is presented, including toxicokinetic evaluation. Case Report A 37 yo woman presented with coma unresponsive to naloxone following topiramate ingestion. She had normal vital signs without respiratory depression. She was intubated for airway protection, given 3.5mg lorazepam IV for facial and neck muscle twitching, and transferred to our facility. No additional sedation was required for 18 hours on the ventilator. Following mental status improvement, the patient was extubated. Confusion, dysarthria and imbalance resolved over the next 2 days. Nonanion gap metabolic acidosis persisted for 3 days. Peak serum topiramate level was 356.6mcg/ml(5–20). Discussion Massive topiramate ingestion led to prolonged coma with normal vital signs and nonanion gap metabolic acidosis. Coma of this severity has not been previously reported. Serum half-life which has not been studied after overdose was 15.79 hours. Despite the large ingestion and significant presenting symptoms, the patient recovered fully with supportive intensive care alone. Conclusion Massive acute topiramate ingestion may lead to nonanion gap metabolic acidosis and prolonged coma which resolves with intensive supportive care. Toxicokinetic data following large, suicidal ingestion of topiramate were similar to previously published pharmacokinetic information.

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Toxicology laboratory analysis and human exposure top-chloroaniline

Cited by 32 publications

References 8 publications

Two Cases of Methemoglobinemia Induced by the Exposure to Nitrobenzene and Aniline

Two Cases of Methemoglobinemia Induced by the Exposure to Nitrobenzene and Aniline

Degradation of p-chloroaniline by persulfate activated with ferrous sulfide ore particles

Clinical Effects and Toxicokinetic Evaluation Following Massive Topiramate Ingestion

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