Toxicology and Biological Monitoring of Metals in Humans

Erythropoietic effects of low‐dose cobalt application

“…The administration of a low dose of Co 2+ (1 mg/day) for 90 consecutive days had no effect on [Hb], Hct or RBC, while after higher daily doses (65 mg), Co 2+ had a strong effect on [Hb] and reticulocytes . In rats, however, the application of 0.12 mg/kg, which is almost equivalent to the 10 mg dose used in our studies, significantly increased [Hb], Hct and RBC …”

Simultaneous Production and Surface Functionalization of Silver Nanoparticles for Label-free Colorimetric Detection of Copper Ion

“…1,2 This is because Cu 2+ ion plays a major role in various metabolic pathways, [3][4][5] and excess uptake of Cu 2+ can build up in the kidneys, brain, and eyes to cause neurological problems, liver failure or kidney dysfunction. [6][7][8] Due to its important role, a large number of methods have been developed for the quantitative determination of metal ions in aqueous solution, [9][10][11] such as electrochemical methods, 12 chromatography-based methods, 13,14 microfluidic devices, 15 and spectroscopic methods.…”

Investigation of metal toxicity leads to the identification of novel translation associated genes in yeast (Saccharomyces cerevisiae)

“…Mutant strains were either selected from the library of gene deletions (Tong et al, 2001) in MATa haploid form or a PCR-based gene knockout approach was used to achieve gene deletion. Targeted gene knockout strains were generated by PCR-based homologous recombination gene deletion strategy utilizing the clonNAT selection gene 2018). Plasmid and gene transformation were performed by using a chemical-transformation strategy (LiOAc method) and confirmed via colony PCR (Alamgir et al, 2010;Samanfar et al, 2017).…”

“…These highly-toxic heavy metals include cadmium (Cd) and nickel (Ni) which have been long-term hazards to human health (Lin, 1998;Godt et al, 2006;. Majority of human exposure to these kinds of elements generally happens through contact with a polluted environment and/or product which is often due to occupational hazards (Järup, 2003;Carson, 2018;Moteshareie et al, 2018).…”

“…Overtime, the increase anthropogenic activities have resulted in the accumulation of heavy metal pollutants in our environment, leading to increasing concerns regarding ecological and global public health (Carson, 2018).…”