Toxicological studies on Acanthus montanus leaf extracts in male and female albino rats

Adaku, V Iwueke; Ezinne, C Chukwu; Obinna, Uchewa O.; Osuocha, K U

doi:10.33472/afjbs.3.1.2021.34-51

Cited by 2 publications

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“…Kaempferol-3-Orutinoside, kaempferol [84], α-and β-amyrins have been isolated from this plant [85]. The leaves of A. montanus was reported to have the likelihood of exhibiting renal and hepatic impairment with high dosages (400-800 mg/kg) [86]. Some of the chemical constituents present in it include syringic acid, acanmontanoside, decaffeoylverbascoside, verbascoside, isoverbascoside, leucosceptoside A, and ebracteatoside B [87].…”

Section: Discussionmentioning

confidence: 99%

Survey of Traditional Birth Attendants in Sagbama and Southern Ijaw Local Government Areas of Bayelsa State

Alade

2022

GJPPS

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The indigenous people of Ijaw in Southern Nigeria are endowed with a deep culture of Traditional birth attendance, and they make use of medicinal plants in their practice to assist in ante- and post-natal cares. It is therefore imperative to document their rich knowledge to avoid its extinction. The work was performed with the aim of identifying and documenting the botanicals employed by the traditional birth attendants in some Ijaw tribes of Bayelsa State. The study was carried out by employing semi-structured questionnaires amidst personal interviews which were administered to forty-five traditional birth attendants (TBAs) between April and August 2019 to obtain information. Thirty-six medicinal plant species belonging to thirty-five genera within twenty- four families were mentioned by the TBAs mostly for labour induction (22.04%). Female fertility (14.47%) threatened abortion (13.49%) and foetal development (10.20%) were treated with Ageratum conyzoides (L.) L. (Compositae), Vernonia amygdalina Delile (Compositae), Bryophyllum pinnatum (Lam.) Oken and Acanthaceae, respectively making the Compositae the most important family. Of these, V. amygdalina was the most cited plant by the TBAs with frequency index (FI) of 44.44, while B. pinnatum ranked the next with FI=40.00. The survey provides an authentic data from TBAs for documentation which will be helpful for researchers in drug development as well as preserving the cultural heritage towards increasing the health manpower of the country.

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Section: Discussionmentioning

confidence: 99%

Survey of Traditional Birth Attendants in Sagbama and Southern Ijaw Local Government Areas of Bayelsa State

Alade

2022

GJPPS

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“…Oxalates which are classified as antinutrients were present in the leaves and roots of Acanthus Montanus in very small quantities which may be responsible for the unique safety of the plant according to toxicological studies done on the plant 27 .…”

Section: Alkaloidsmentioning

confidence: 99%

Phytochemical Contents and In Vitro Pathogenic Microbial Growth Inhibitory Activities of Acanthus montanus Root and Leaf Extracts

Ndukwe,

Okoronkwo,

Jack

2024

Nig. J. Chem. Res.

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The study was directed at extraction, bioactivity analysis and ascertaining phytochemical composition of the leaf and root extracts of Acanthus montanus. Acanthus montanus (Acanthaceae family) is a shrub that is popularly grown in tropical countries of the world. The plant materials were harvested from Choba community in Rivers State, Nigeria. Extracts of Acanthus montanus (28.3, 19.45 and 25.5 g of n-hexane, ethylacetate and ethanol leaf extracts; and 3.45, 11.32 and 12.44 g of n-hexane, ethylacetate and ethanol root extracts respectively) were obtained through sequential maceration and were separately subjected to in vitro bioassay against a wide range of pathogenic microbes using the agar well diffusion method. Fifteen microorganisms were employed in the investigation, eight bacteria which included Salmonella typhi, Salmonella paratyphi, Pseudomonas aeruginosa, Shigella sonniea, Shigella dysentariae, Escherichia coli, Staphylococcus aureus, Staphylococcus pyogenes and seven fungi which included Candida albicans, Sacharomyces cerevisiae, Rhizopus eligastus, Aspergillus flavus, Aspergillus fumigates, Fusa equisetti and Aspergillus niger. The crude extracts exhibited high microbial growth inhibitory activities with zones of inhibition which ranged between 14 and 34 mm, though there was moderate (19 mm zone of inhibition), or no activity observed for the n-hexane leaf and root extracts. All test organisms were sensitive to the extracts. Standard analytical methods and Gas Chromatography - Flame Ionization Detector (GC-FID) were used for analysis and quantification of the phytochemicals present in the extracts. Major phytochemical contents of the leaf and root extracts included flavonoids (86% - 52.66%), alkaloids (10.66% - 3.25%) and other phenolic compounds (20.52% - 6.38%). In conclusion, the leaf and root extracts of Acanthus montanus are broad-spectrum antimicrobial agents also rich in flavonoids.

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Toxicological studies on Acanthus montanus leaf extracts in male and female albino rats

Cited by 2 publications

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Survey of Traditional Birth Attendants in Sagbama and Southern Ijaw Local Government Areas of Bayelsa State

Survey of Traditional Birth Attendants in Sagbama and Southern Ijaw Local Government Areas of Bayelsa State

Phytochemical Contents and In Vitro Pathogenic Microbial Growth Inhibitory Activities of Acanthus montanus Root and Leaf Extracts

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