Toxicological screening

Parasuraman, Subramani

doi:10.4103/0976-500x.81895

Cited by 423 publications

(251 citation statements)

References 17 publications

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“…Any changes in body weights of the rat, changes in skin and fur, eyes and mucous membranes, salivation, nasal discharge, urination and behavioral (sedation, depression), neuromuscular (tremors, convulsions), cardiovascular changes, lethargy, sleep and coma were observed. 14 …”

mentioning

confidence: 99%

Anti-Obesity Efficacy of Roots of Stereospermum suaveolens in High Fat-Induced Obese Rats

Kaveripakam¹,

Adikay²,

Retnasamy³

2017

JYP

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mentioning

confidence: 99%

Anti-Obesity Efficacy of Roots of Stereospermum suaveolens in High Fat-Induced Obese Rats

Kaveripakam¹,

Adikay²,

Retnasamy³

2017

JYP

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“…These include the fixed dose procedure (FDP), the ATC method, and the up and down (UDP) method. The FDP assesses the nonlethal toxicity rather than the lethal dose [21]. The investigational compound is administered at fixed dose levels of 5, 50, 500, and 2000 mg/kg and the animal is observed for a defined period.…”

Section: Discussionmentioning

confidence: 99%

“…Swiss albino mice, weighing (18)(19)(20)(21)(22), were obtained from the Department of Pharmacology and Toxicology, College of Pharmacy, University of Hail, Kingdom of Saudi Arabia. All the animals were housed in groups of (n=3/cage) in standard plastic cages with wood chips as bedding material.…”

Section: Experimental Animalsmentioning

confidence: 99%

Acute Toxicity Testing of Newly Discovered Potential Antihepatitis B Virus Agents of Plant Origin

Aljofan

et al. 2017

Asian J Pharm Clin Res

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Objective: Our previous studies indicate that alkaloids could be developed as potential antihepatitis B agents. In the present study, we investigated the in vitro antihepatitis B virus (HBV) activity and in vivo acute oral toxicity of three isoquinoline alkaloids [-(-) Canadine, Corydadine, and Berberine] obtained from Fumaria and Corydalis species. The compounds were selected based on their therapeutic indexes calculated previously in vitro. Methods:The antiviral activity and cytotoxicity of selected isoquinoline alkaloids were evaluated in vitro in HepG2 cells. In vivo, acute oral toxicity was performed in female mice following the Organization for Economic Cooperation and Development test guideline-423 (acute toxicity class method). Results:The selected agents have shown high antiviral activity against HBV and low cytotoxicity in vitro. The results obtained from an acute oral toxicity study revealed that the LD 50 of all the test compounds was >2000 mg/kg when administered orally to mice. All the tested compounds fall under the category 5 (unclassified) according to the Globally Harmonized System, with a LD 50 value >2000 mg/kg when orally administered to mice. Conclusion:The results of the study revealed that OR-13 and MNAD can be studied further and can be developed as antihepatitis B drugs.

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“…Tonic Clonic seizures induced in mice are antagonized by anticonvulsant agents. 11,12 The animals were divided into three groups. Each group contained six mice of either sex having 20-28 gm weight.…”

Section: -16mentioning

confidence: 99%

“…SHIMADZU Affinity-I spectrophotometer was for recording the IR spectrum. General synthesis scheme of the target compound [7][8][9][10][11] (SMMB [1][2][3] ) To a solution of barbituric acid (0.01 mol)/ thiobarbituric acid (0.01 mol) in methanol as solvent, formaldehyde (0.02 mol) and 3-amino-2-methylquinazolin-4(3H)-one (0.02 mol) were added drop wise. The reaction mixture was refluxed on a steam bath for 4 hr.…”

Section: Chemistrymentioning

confidence: 99%

In silico Design, Synthesis and Pharmacological screening of Quinazolinones as NMDA receptor antagonists for Anticonvulsant activity: Part II

Nerkar¹,

Sahu²,

Sawant³

2015

JYP

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Background: N-methyl-D-Aspartate (NMDA) receptor plays a main role in eliptogenisis and its inhibition has therapeutic significance in development of anticonvulsants. Prioritized quinazolinone molecules were synthesized, evaluated in vivo by AOT and then for anticonvulsant activity in NMDA induced convulsion model. Method: In silico Screening of prioritized molecule was done by biological activity predictions, partition coefficient predictions (Log P), molecular docking on NMDA receptors, in silico ADME predictions using PASS server and mol inspiration software, V Life MDS 4.3 software and Pre ADMET server respectively. This gave biological activity (BA) score for anticonvulsant activity and predicted Log P values (p Log P). The standard Log P required for anticonvulsant activities being more than 2.00, therefore molecules were also prioritized based on this p Log P criteria. Docking showed results of antagonism in silico as compared with Memnatine and molecules were prioritized for synthesis based on this criteria. Result: Quinazolinone molecules were prioritized based upon docking score, ADME and BA score, synthesized and pharmacologically screened for anticonvulsant activity. Conclusion: SMMB 1 , SMMB 2 , SMMB 3 showed the prominent anticonvulsant activity as compared with memantine used as standard for in vivo anticonvulsant activity. The compounds can serve as anticonvulsant Leads through NMDA antagonism.

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Toxicological screening

Cited by 423 publications

References 17 publications

Anti-Obesity Efficacy of Roots of Stereospermum suaveolens in High Fat-Induced Obese Rats

Anti-Obesity Efficacy of Roots of Stereospermum suaveolens in High Fat-Induced Obese Rats

Acute Toxicity Testing of Newly Discovered Potential Antihepatitis B Virus Agents of Plant Origin

In silico Design, Synthesis and Pharmacological screening of Quinazolinones as NMDA receptor antagonists for Anticonvulsant activity: Part II

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