Toxicological profile and acetylcholinesterase inhibitory potential of Palicourea deflexa, a source of β-carboline alkaloids

Bertelli, Pablo Ricardo; Biegelmeyer, Renata; Rico, Eduardo Pacheco; Klein‐Júnior, Luiz Carlos; Toson, Natally S.B.; Minetto, Luciane; Bordignon, Sérgio A. L.; Gasper, André Luís de; Moura, Sidnei; Oliveira, Diogo Lösch de; Henriques, Amélia T.

doi:10.1016/j.cbpc.2017.09.003

Cited by 14 publications

(10 citation statements)

References 60 publications

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“…Harman-3-carboxylic acid was detected in Palicourea deflexa (DC.) Borhidi (Bertelli et al 2017) and another derivative, tetrahydronorharman-1-one, was recently isolated from Palicourea winkleri Borhidi (Berger et al 2017). Finally, 2-methyl tetrahydro-b-carboline (i.e.…”

Section: Simple Indole Alkaloidsmentioning

confidence: 99%

A revised classification of the sister tribes Palicoureeae and Psychotrieae (Rubiaceae) indicates genus-specific alkaloid accumulation

et al. 2021

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Tribes Palicoureeae and Psychotrieae (Rubiaceae, Gentianales) are complex and speciose sister groups with a pantropical distribution. Since the initial studies on ipecacuanha more than two centuries ago, species of the group have been subject to numerous phytochemical studies yielding diverse specialized ("secondary") metabolites, most of them alkaloids. However, the generic limits within the tribes have long been unclear and only recently, monophyletic genera have been delimited and segregated from a once broadly circumscribed Psychotria. Thus, a phylogeny-based and taxonomically updated review of phytochemical literature was performed which allowed assigning the bulk of phytochemical data previously reported for Psychotria to various segregate genera such as Carapichea, Eumachia and Palicourea. This review not only challenges the common perception of Psychotria as a monoterpene-indole alkaloid-rich genus. It also highlights that each of its relatives differs by accumulating specific groups of alkaloids, which is of major importance for understanding animal-plant interactions such as herbivory, as well as for drug discovery. The alkaloid complement of each of these genera is here enumerated and discussed, which should provide a framework for future studies addressing the biosynthesis, evolution, ecological and pharmacological significance of specialized metabolite differentiation in this abundant, ecologically and ethnopharmacologically important group.

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Section: Simple Indole Alkaloidsmentioning

confidence: 99%

A revised classification of the sister tribes Palicoureeae and Psychotrieae (Rubiaceae) indicates genus-specific alkaloid accumulation

et al. 2021

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“…Scientists are discovering new innovative paths for evaluating biochemical processes [ 19 ]. Within 5–6 days dpf, zebrafish development reflects the full developmental period of a vertebrate embryo before it becomes self-sustainable and, therefore, this substitute organism is not currently recognized as a genuine in vivo form by European law [ 52 ].…”

Section: Zebrafish As a Suitable Alternative Animal Model For Toximentioning

confidence: 99%

“…Numerous toxicity studies of specific chemicals have shown a significant correlation between results for zebrafish embryos and acute toxicity of fish [ 57 ]. The FET test aims to determine the acute toxicity of the embryonic phases and establish variables for zebrafish [ 52 ]. It is based on mortality and teratogenesis of the zebrafish embryos [ 46 ].…”

Section: Zebrafish As a Suitable Alternative Animal Model For Toximentioning

confidence: 99%

“…The possibility of tracking many toxicity endpoints, including alteration of molecular processes and malformations, is one of FET’s main advantages with Danio rerio [ 59 ]. With the FET test, acute toxicity is assessed based on positive results, and embryo formation is examined every day for any unusual developmental phenotypes, especially morphological defects, including (i) coagulation of fertilized eggs; (ii) lack of somite formation; (iii) lack of detachment of the tail-bud from the yolk sac; and (iv) lack of a heartbeat [ 52 ]. Nagel (2002) outlined these toxicity indicators as measured using an inverse light microscope based on “yes” or “no” responses to the presence of the four factors [ 60 ].…”

Section: Zebrafish As a Suitable Alternative Animal Model For Toximentioning

confidence: 99%

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Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants

Chahardehi

Arsad

Lim

2020

Plants

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The zebrafish (Danio rerio) is used as an embryonic and larval model to perform in vitro experiments and developmental toxicity studies. Zebrafish may be used to determine the toxicity of samples in early screening assays, often in a high-throughput manner. The zebrafish embryotoxicity model is at the leading edge of toxicology research due to the short time required for analyses, transparency of embryos, short life cycle, high fertility, and genetic data similarity. Zebrafish toxicity studies range from assessing the toxicity of bioactive compounds or crude extracts from plants to determining the optimal process. Most of the studied extracts were polar, such as ethanol, methanol, and aqueous solutions, which were used to detect the toxicity and bioactivity. This review examines the latest research using zebrafish as a study model and highlights its power as a tool for detecting toxicity of medicinal plants and its effectiveness at enhancing the understanding of new drug generation. The goal of this review was to develop a link to ethnopharmacological zebrafish studies that can be used by other researchers to conduct future research.

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“…80 Moreover, in the last few years, many transgenic, knockdown and mutant lineages have been created for pharmacological studies. 77,80 In Brazil, the zebrafish has been used for preclinical analysis of cancer drugs, [81][82][83][84] toxicological analysis of medicinal plant extracts, [85][86][87] and mainly in studies on several antipsychotic drugs. [88][89][90] A number of studies in this area focus on the toxicological effects of natural toxins, such as cyanotoxins 91,92 and cnidarian toxins 93,94 ; the latter and snake venom toxins may be useful for new drug development.…”

Section: Research Areasmentioning

confidence: 99%

Zebrafish as an Emerging Model System in the Global South: Two Decades of Research in Brazil

et al. 2020

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The zebrafish (Danio rerio) is an emerging model system in several research areas worldwide, especially in the Global South. In this context, the present study revised the historical use and trends of zebrafish as experimental models in Brazil. The data concerning the bibliometric parameters, research areas, geographic distribution, experimental design, zebrafish strain, and reporter lines, as well as recent advances were revised. In addition, the comparative trends of Brazilian and global research were discussed. Revised data showed the rapid growth of Brazilian scientific production using zebrafish as a model, especially in three main research areas (Neuroscience &and Behavior, Pharmacology and Toxicology, and Environment/Ecology). Studies were conducted in 19 Brazilian states (70.37%), confirming the wide geographic distribution and importance of zebrafish research. Results indicated that research related to toxicological approaches are widespread in Global South countries such as Brazil. Studies were performed mainly using in vivo tests (89.58%) with adult fish (59.75%) and embryos (30.67%). Moreover, significant research gaps and recommendations for future research are presented. The present study shows that the zebrafish is a suitable vertebrate model system in the Global South.

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Toxicological profile and acetylcholinesterase inhibitory potential of Palicourea deflexa, a source of β-carboline alkaloids

Cited by 14 publications

References 60 publications

A revised classification of the sister tribes Palicoureeae and Psychotrieae (Rubiaceae) indicates genus-specific alkaloid accumulation

A revised classification of the sister tribes Palicoureeae and Psychotrieae (Rubiaceae) indicates genus-specific alkaloid accumulation

Zebrafish as a Successful Animal Model for Screening Toxicity of Medicinal Plants

Zebrafish as an Emerging Model System in the Global South: Two Decades of Research in Brazil

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