Toxicological evaluation of dextran stabilized iron oxide nanoparticles in human peripheral blood lymphocytes

Easo, Sheeja Liza; Mohanan, P.V.

doi:10.1116/1.4962268

Cited by 11 publications

(6 citation statements)

References 49 publications

(42 reference statements)

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“…MNP toxicity usually occurs mainly when high doses and prolonged exposure times are used [87,88] or in the presence of certain coatings [89]. Besides, there are several studies demonstrating the low toxicity of MNPs in both human and murine T and NK cell lines and in primary T and NK cells [75,78,80,[89][90][91][92][93][94][95][96][97][98][99].…”

Section: The Interaction Between Mnps and Lymphoid Cellsmentioning

confidence: 99%

Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting

2020

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Adoptive cell transfer therapy is a promising anti-tumor immunotherapy in which effector immune cells are transferred to patients to treat tumors. However, one of its main limitations is the inefficient trafficking of inoculated effector cells to the tumor site and the small percentage of effector cells that remain activated when reaching the tumor. Multiple strategies have been attempted to improve the entry of effector cells into the tumor environment, often based on tumor types. It would be, however, interesting to develop a more general approach, to improve and facilitate the migration of specific activated effector lymphoid cells to any tumor type. We and others have recently demonstrated the potential for adoptive cell transfer therapy of the combined use of magnetic nanoparticle-loaded lymphoid effector cells together with the application of an external magnetic field to promote the accumulation and retention of lymphoid cells in specific body locations. The aim of this review is to summarize and highlight the recent findings in the field of magnetic accumulation and retention of effector cells in tumors after adoptive transfer, and to discuss the possibility of using this approach for tumor targeting with chimeric antigen receptor (CAR) T-cells.

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Section: The Interaction Between Mnps and Lymphoid Cellsmentioning

confidence: 99%

Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting

2020

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“…Ultrafine nano-oxides can cause gastroduodenal corrosive injury in humans without systemic toxicity. Inhaled ZnO can cause pulmonary toxicity but minimal toxicity to other organs (Kaushik et al 2008;Ghaghada et al 2009;ZubairIqbal et al 2015;Kanal 2016;Tomonori Kanda et al 2016;Liza and Valappil Mohanan 2016;Frangville et al 2016). Increased consumption of fine and ultrafine particulate matter is hypothesized to exacerbate inflammatory bowel disease (Fakhar-e-Alam et al 2017a; Shaheen et al 2017a, b;Fakhar-e-Alam et al 2017b).…”

Section: Role Of Nanomaterials In Photodynamic Therapymentioning

confidence: 99%

“…Well-stabilized form of iron oxide nanoparticles with dextran (DIONPs), a potential candidate for hyperthermia treatment, led to oxidative stress of premalignant/human blood lymphocytes and malignant tissues/cells due to their ultrafine size and magnetic susceptibility, while their individual form may be useful for MRI techniques (Liza and Valappil Mohanan 2016).…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Gadolinium-Doped Iron Nanostructures Decorated with Novel Drugs for Magnetic Resonance Imaging, Photodynamic, and Photothermal Therapy Applications

Fakhar-e-Alam

Mahmood²,

Nasır³

et al. 2020

Magnetic Nanoheterostructures

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Multidrug drug resistance (MDR) builds many limitations/troubles/problems in magnetic resonance imaging (MRI) and treatment techniques. In this strategy, novel idea of polyethylene glycol/polyacrylic acid (PEG-co-PAA)-decorated gadolinium-doped iron was employed for cancer diagnostics and therapy purposes. In real sense, multifarious/various morphology of Gd-doped Fe-NMPs was found to be useful in versatile format of biomedical applications. Schematic of ongoing experimental strategy illustrates that three efficient photosensitizers, e.g., chlorine e6, Foscan ® , and 5-ALA were decorated with Gd-doped iron capsulated with PEG-co-PAA such that their size/morphology consists within range of 100-120 nm of nanospheres. Final form of this nanospheres/nanocapsule plays a vital role through synergistic response of mutual plasmonic reaction of drug decorated nanocapsule. One of the prime M. Fakhar-e-Alam (B) • A. Mahmood (B)

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“…Due to their superparamagnetic properties, which prevent particle aggregation, magnetite and maghemite nanoparticles are the ideal candidates for many biomedical applications . SPIONs have been also used in drug targeted tumor therapies due to their unique ability to be guided by an external magnetic field directly to the affected area, thus enabling a reduction of the treatment dose and minimizing the side effects of the cancer treatment .…”

Section: Introductionmentioning

confidence: 99%

Ultrasound studies on magnetic fluids based on maghemite nanoparticles

Predoi

Popa

Predoi³

2017

Polymer Engineering & Sci

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In the last decades, the study of magnetic fluids with different biomedical applications such as targeted delivery of a chemotherapeutic solution to the tumor site has been of high interest. For this purpose, ultrasonic and antimicrobial studies were used to characterize the aqueous solutions based on maghemite nanoparticles. The maghemite (γ‐Fe2O3) and dextran‐coated maghemite nanoparticles (DMNp) were synthesized by coprecipitation method. The spherical shape of the nanoparticles and uniform size with an average diameter around 9.5 ± 0.5 nm for γ‐Fe2O3 were observed in transmission electron microscopy micrographs. Dynamic light scattering was used to determine the hydrodynamic size of γ‐Fe2O3 nanoparticles and DMNp in suspensions. The hydrodynamic diameter obtained of γ‐Fe2O3 and DMNp was 17 and 21 nm, respectively. Moreover, a noninvasive method based on ultrasounds was used to characterize the aqueous solutions. The preliminary results showed the attainable accuracy in determining acoustic wave velocity and attenuation in various solutions. These data could be correlated with particle density and size. More than that, velocity and attenuation can be used as characteristic parameters of a given solution. A finite element model of the dispersed particles, correlated with measured velocity, allowed to solve for the elastic properties of the particles. POLYM. ENG. SCI., 57:485–490, 2017. © 2017 Society of Plastics Engineers

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Toxicological evaluation of dextran stabilized iron oxide nanoparticles in human peripheral blood lymphocytes

Cited by 11 publications

References 49 publications

Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting

Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting

Gadolinium-Doped Iron Nanostructures Decorated with Novel Drugs for Magnetic Resonance Imaging, Photodynamic, and Photothermal Therapy Applications

Ultrasound studies on magnetic fluids based on maghemite nanoparticles

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