Toxicological effects of furan on the reproductive system of male rats: An “in vitro” and “in vivo"-based endocrinological and spermatogonial study

Rehman, Humaira; Jahan, Sarwat; Ullah, Imdad; Winberg, Svante

doi:10.1016/j.chemosphere.2019.05.063

Cited by 16 publications

(18 citation statements)

References 31 publications

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“…[1][2][3][4][5] Furan is also present in the environment, as it is the main constituent of cigarette smoke, wood smoke, and exhaust gases from engines. 6 Because of the toxic nature of furan and its excessive daily intake in humans through diet and air, it has become a matter of concern. The US Food and Drug Administration has reported the presence of furan in food items in various surveys.…”

Section: Introductionmentioning

confidence: 99%

“…13 Furan needs to be removed from consumer products because of its negative effects on human health. 6 Various toxicants are dangerous to cell membranes since they cause increase in lipid peroxidation, production of reactive oxygen species (ROS), and DNA damage in the cells. 5,11,14 Furan can easily pass through biological membranes due to its low polarity and acts as an endocrine disruptor as it has been reported previously that exposure to different concentrations of furan resulted in the disturbance of the reproductive neuroendocrine system in rats.…”

Section: Introductionmentioning

confidence: 99%

“…15,16 Previous literature on furan reported that its exposure causes reproductive impairment by disturbing reproductive organ growth; spermatogenesis; testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) secretion; and reproductive performances. 5,6,16 It has been previously reported that hazardous environmental toxicants can bring variations in the signaling pathways of cells and defensive and protective systems of the antioxidant levels of the cells by affecting physiological conditions. 12,17 Furan caused significant changes in histological structure of cells, malondialdehyde levels, antioxidant enzyme activities, and caused DNA damage in lymphocytes and sperm cells by producing ROS.…”

Section: Introductionmentioning

confidence: 99%

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Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

et al. 2020

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The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats. Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg−1 for 10 weeks (males) and 2 weeks (females) and then mated. Results of F0 indicated that in the furan-treated groups (5 mg kg−1 and 10 mg kg−1), body weight (bw) gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at 10 mg kg−1. Number of live pups at birth were decreased ( p < 0.001) at 10 mg kg−1. At postnatal day (PND) 70, a significant ( p = 0.03) decrease in testosterone levels of male rats and estrogen levels of female rats ( p = 0.05) was observed in 10 mg kg−1 furan-treated group in F1 generation. Luteinizing hormone, follicle-stimulating hormone, and progesterone levels were also reduced, but their reduction was not statistically significant in all groups. In higher dose furan group (10 mg kg−1), testicular and ovarian weights were reduced in F1 generation at PND 70, with decreased daily sperm production ( p = 0.01) and disturbed estrous cyclicity ( p < 0.01). Some histopathological changes were also observed in testis and ovaries in groups whose parents were previously exposed to 10 mg kg−1 bw of furan group. Based on the above results, it is suggested that exposure to food-based contaminant furan induced remarkable changes in the F0 (parental stage) and F1 (offspring, pubertal, and adult stage) generations of Sprague Dawley rats.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

et al. 2020

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“…Oxidative stress is one of the main mechanisms involved in mediating the deleterious effects of environmental contaminants on male reproduction (Darbandi et al, 2018;Rehman, Jahan, Ullah, & Winberg, 2019) as increased levels of ROS inhibit the activity of steroidogenic enzymes and activate apoptotic pathways in testis resulting in impairment of steroidogenesis and spermatogenesis, respectively (Quan et al, 2017;Sheweita et al, 2016;Shi, Sekulovski, MacLean, & Hayashi, 2018). Furthermore, alterations in the antioxidant milieu of the epididymis induced by environmental contaminants negatively affect the sperm maturation process resulting in poor sperm quality (Adewoyin et al, 2017;Rahman et al, 2019).…”

Section: Mechanis M Of Ac Ti On Of Environmental Contaminantsmentioning

confidence: 99%

Environmental contaminants and male infertility: Effects and mechanisms

et al. 2020

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The global incidence of infertility has risen to 15% in contrast to 7%-8% in the early 1960s (Mascarenhas, Flaxman, Boerma, Vanderpoel, & Stevens, 2012). Over the past several decades, a significant deterioration in male reproductive health has been reported in association with increased industrialisation, which has contributed to a massive release of synthetic pollutants into the environment (Rim, 2017; Skakkebaek et al., 2016). The concerns over declining male reproductive health were elicited by one of the landmark publications by Carlsen et al., which revealed a worldwide reduction in the average sperm count to half between 1940 and 1990 (Carlsen, Giwercman, Keiding, & Skakkebaek, 1992). These findings prompted several scientists, mainly Swan et al. to re-evaluate the trend in semen quality over time in different regions throughout the world and eventually confirmed a significant decrease in sperm concentration in western countries (Swan, Elkin, & Fenster, 1997). Incidentally, a parallel increase in the occurrence of testicular cancer and congenital abnormalities (cryptorchidism and hypospadias) were reported in several countries (Ferguson & Agoulnik, 2013; Hutson, 2000). These observations prompted researchers to explore the potential role of common environmental factors in causing a decline in male reproductive health. In 1993, it was hypothesised that the growing incidence of male reproductive anomalies could be due to exposure to chemicals possessing oestrogenic property (Sharpe & Skakkebaek, 1993).

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“…Furan is a colorless toxic chemical produced in various food items during heat processing and in some industrial processes (Delatour et al, 2020;Rehman et al, 2019;Morehouse et al, 2018;Sirot et al, 2019). It has been reported that furan can induce oxidative stress, endocrine disruption and toxic effects on the reproductive system of male rats (Rehman et al, 2019). However, other studies have shown its ability to inhibit tyrosinase, which is an enzyme responsible for many skin disorders and diseases (Barros et al, 2019).…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure ofN′-[4-(dimethylamino)benzylidene]furan-2-carbohydrazide monohydrate

et al. 2020

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The condensation of 2-furoic hydrazide and 4-dimethyl aminobenzaldehyde in ethanol yielded a yellow solid formulated as the title compound, C14H15N3O2·H2O. The crystal packing is stabilized by intermolecular O(water)—H...O,N(carbohydrazide) and N—H...O(water) hydrogen bonds, which form a two-dimensional network along the bc plane. Additional C—H...O interactions link the molecules into a three-dimensional network. The dihedral angle between the mean planes of the benzene and the furan ring is 34.47 (6)°. The carbohydrazide moiety, i.e., the C=N—N—C=O fragment and the benzene ring are almost coplanar, with an angle of 6.75 (9)° between their mean planes.

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Toxicological effects of furan on the reproductive system of male rats: An “in vitro” and “in vivo"-based endocrinological and spermatogonial study

Cited by 16 publications

References 31 publications

Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats: An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)

Environmental contaminants and male infertility: Effects and mechanisms

Crystal structure ofN′-[4-(dimethylamino)benzylidene]furan-2-carbohydrazide monohydrate

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