Toxicological effects of dichlorvos (DDVP) on brain and liver acetylcholinesterase (AChE) activity of Tilapia mossambica, peters

Rath, Sasmita; Misra, Β. N.

doi:10.1016/0300-483x(81)90133-5

Cited by 46 publications

(13 citation statements)

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“…Chlorpyrifos exerts its toxicity by irreversibly binding to a serine hydroxyl group on the AChE resulting in cholinergic over-stimulation (Osterloh et al 1983). The degree of AChE inhibition in liver of Tilapia mossambica in relation to the interacting effects of aging and sublethal concentrations of dichlorvos showed a positive correlation with insecticide concentration and the time of exposure (Rath and Mishra 1981). In the current study, AChE activity in fish exposed to chlorpyrifos did not fully recover except for the low concentration group of chlorpyrifos when the fish were transferred into pesticide-free water.…”

Section: Resultscontrasting

confidence: 61%

Oxidative Stress Responses and Recovery Patterns in the Liver of Oreochromis niloticus Exposed to Chlorpyrifos-Ethyl

Oruç

2012

Bull Environ Contam Toxicol

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Chlorpyrifos is the most common insecticide in freshwater ecosystems, and detected in agricultural and fishery product. In this study, Oreochromis niloticus were exposed to 5, 10 and 15 ppb sublethal concentrations of chlorpyrifos in order to determine the oxidative stress response in liver. Acetylcholinesterase (AChE) activity was significantly inhibited. Superoxide dismutase activity (SOD) increased after 15 days of chlorpyrifos treatments at all concentrations (146.95%, 53.04%, 208.70%, respectively). Malondialdehyde levels were higher than that of the control level after 15 days of 5 ppb (95.65%), 10 ppb (69.56%) and 15 ppb (252.17%) chlorpyrifos treatments. Malondialdehyde levels were also increased ranging from 59.09%, 113.63% to 195.46% after 30 days of 5, 10 and 15 ppb chlorpyrifos exposures. Glutathione S-transferase activity decreased except for 15 days low concentration exposure. Catalase (CAT) activity decreased while there is no significant alteration in glutathione peroxidase activity. After recovery period, the low concentration group of chlorpyrifos provided a protection in AChE activity during recovery, but fish were observed to be unable to overcome the inhibition of AChE activity at high concentration groups. CAT activity remained reduced, SOD activity increased whereas the other biochemical parameters recovered to control levels. Results of this study suggest that chlorpyrifos induces oxidative stress in the liver of O. niloticus and this effect is not related with anti-acetylcholinesterase activity of pesticide.

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Section: Resultscontrasting

confidence: 61%

Oxidative Stress Responses and Recovery Patterns in the Liver of Oreochromis niloticus Exposed to Chlorpyrifos-Ethyl

Oruç

2012

Bull Environ Contam Toxicol

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“…This result agrees with results of similar comparisons in the literature (Weiss, 1961;Rath and Misra, 1980;ZinkI et al, 1987). In any monitoring using ChE activity, similarly-sized organisms should be used.…”

Section: General Conclusionsupporting

confidence: 91%

“…Total length is a sensible measure of size to use in comparisons. Generally, wet weight is used in size comparisons (Rath and Misra, 1980;ZinkI et al, 1987). However, adults' wet weight is strongly influenced by their reproductive status; adults collected from the UMR were in various reproductive conditions.…”

Section: Variation In Choiinesterase Activity By Fish Total Lengthmentioning

confidence: 99%

“…Most of the variation occurred in the smallest fish; adult fish did not vary much in brain ChE activity with brain weight (Weiss, 1961). In tilapia fTiiaoia mossambicaV a strongly negative, linear correlation was found between body weight and both brain and liver ChE activity (Rath and Misra, 1980).The difference in ChE activity by size may, at least in some species, be a difference by age. Small rainbow trout (0. mvkiss^.…”

mentioning

confidence: 91%

“…ChE activity is often greater in younger, smaller organisms than in older, larger ones (Weiss, 1961;Rath and Misra, 1980;ZinkI et al, 1987;Gard and Hooper, 1993; Fishwick et al, 1996). Serum and whole body ChE activity has been shown to vary by sex and reproductive status in birds and fish, though the direction of variation differs among species (van der Wei and Welling, 1989;; in contrast, no difference in brain ChE activity has been found by sex or reproductive status in birds or fish studied so far (Hogan, 1970; Coppage, 1972;.…”

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confidence: 99%

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Factors affecting cholinesterase activity in aquatic animals

Beauvais

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This manuscript has been reproduced from the microfilm master. UMI fihns the text directly from the original or copy submitted. Thus, some thesis and dissertation copies are in typewriter face, while others may be from any type of computer printer.The quality of this reproduction is dependent upon the quality of the copy submitted. Broken or indistinct print, colored or poor quality illustrations and photographs, print bleedthrough, substandard margms, and improper alignment can adversely affect reproduction.In the unlikely event that the author did not send UMI a complete manuscript and there are missing pages, these will be noted. Also, if unauthorized copyright material had to be removed, a note will indicate the deletion.Oversize materials (e.g., maps, drawings, charts) are reproduced by sectioning the original, beginning at the upper left-hand comer and continuing from left to right in equal sections with small overlaps. Each original is also photographed in one exposure and is included in reduced form at the back of the book.Photographs included in the original manuscript have been reproduced xerographically in this copy. ICgher quality 6" x 9" black and white photographic prints are available for any photographs or illustrations appearing in this copy for an additional charge. Contact UMI directly to order. UMI GENERAL INTRODUCTIONOrganophosphorus insecticides (OPs) are extensively used throughout the world to control crop pests (Eto, 1991; ERS, 1994). As organochlorlne insecticides have gradually been phased out in response to problems caused by their persistence in the environment, OPs have been a common choice to replace them . In the United States, for example, the top three insecticides applied to field crops in 1993 were chlorpyrifos (3 x 10^ kg), terbufos (2.5 x 10® kg), and methyl parathion (2.3 x 10® kg; ERS, 1994).OPs can enter aquatic systems that drain agricultural watersheds through routes such as direct application for aquatic insect pest control Stevens and Wan-en, 1992), aerial overspray (Hennessey et al., 1992), and runoff from crop fields Richards and Baker, 1993;.Because insecticides that target aquatic pests are formulated for greater effectiveness in water, direct application can result in higher concentrations (e.g., up to 10 |ig/L; , and relatively longer-term exposures (e.g., 2-6 weeks; Yasuno, 1991) than those resulting from other uses. Runoff from fields occurs with rain, and like aerial overspray, results in pulsed events with relatively short exposure periods.Assessment of an aquatic system's exposure to OPs is difficult as these compounds are non-persistent ; they are rapidly hydrolyzed and photolyzed (Weinberger et al., 1982;Wang et al., 1989), taken up by biota , and they readily adsorb to sediments (Sharom et al., 1980; Knuth and 2 Heinis, 1992). Water solubilities of many OPs are low, for example, the solubility of chlorpyrifos is 1-2 mg/L at 25®C, and its mean soil adsorption coefficient (Kd) is 173 mL/g . Therefore. OPs may be found in the aquatic ecosystem for ...

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Utilization of alternative species for toxicity testing: An overview

Goss

Sabourin

1985

J of Applied Toxicology

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Toxicological effects of dichlorvos (DDVP) on brain and liver acetylcholinesterase (AChE) activity of Tilapia mossambica, peters

Cited by 46 publications

References 10 publications

Oxidative Stress Responses and Recovery Patterns in the Liver of Oreochromis niloticus Exposed to Chlorpyrifos-Ethyl

Oxidative Stress Responses and Recovery Patterns in the Liver of Oreochromis niloticus Exposed to Chlorpyrifos-Ethyl

Factors affecting cholinesterase activity in aquatic animals

Utilization of alternative species for toxicity testing: An overview

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