Toxicological assessment of Xanthigen® nutraceutical extract combination: Mutagenicity, genotoxicity and oral toxicity

López-Ríos, Laura; Vega, T. González-Carrascosa; Chirino, Ricardo; Jung, Jae‐Chul; Davis, Barbara; Pérez-Machín, R.; Wiebe, Julia C.

doi:10.1016/j.toxrep.2018.10.007

Cited by 9 publications

(3 citation statements)

References 20 publications

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“…The suppression of adipocyte differentiation and lipid accumulation by Xanthigen was via multiple mechanisms [155]. In addition, Xanthigen was demonstrated to be safe for consumption [156]. The other commercial product is FucoVital (https://www.algatech.com/ algatech-product/fucovital/, accessed on 30 July 2021), which consists of 3% fucoxanthin, omega-3s, and other beneficial fatty acids (extracted from P. tricornutum).…”

Section: Commercial Products and Potential Applications Of Fucoxanthinmentioning

confidence: 99%

The Critical Studies of Fucoxanthin Research Trends from 1928 to June 2021: A Bibliometric Review

et al. 2021

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Fucoxanthin is a major carotenoid in brown macroalgae and diatoms that possesses a broad spectrum of health benefits. This review evaluated the research trends of the fucoxanthin field from 1928 to June 2021 using the bibliometric method. The present findings unraveled that the fucoxanthin field has grown quickly in recent years with a total of 2080 publications. Japan was the most active country in producing fucoxanthin publications. Three Japan institutes were listed in the top ten productive institutions, with Hokkaido University being the most prominent institutional contributor in publishing fucoxanthin articles. The most relevant subject area on fucoxanthin was the agricultural and biological sciences category, while most fucoxanthin articles were published in Marine Drugs. A total of four research concepts emerged based on the bibliometric keywords analysis: “bioactivities”, “photosynthesis”, “optimization of process’’, and “environment”. The “bioactivities” of fucoxanthin was identified as the priority in future research. The current analysis highlighted the importance of collaboration and suggested that global collaboration could be the key to valorizing and efficiently boosting the consumer acceptability of fucoxanthin. The present bibliometric analysis offers valuable insights into the research trends of fucoxanthin to construct a better future development of this treasurable carotenoid.

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Section: Commercial Products and Potential Applications Of Fucoxanthinmentioning

confidence: 99%

The Critical Studies of Fucoxanthin Research Trends from 1928 to June 2021: A Bibliometric Review

et al. 2021

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“…It is mainly in the form of these primary metabolites that fucoxanthin exerts functional activity in the human body . In addition, some researchers have proven that fucoxanthin has no toxicity to the liver, spleen, kidney, and gonads of mice and rat. − …”

Section: Chemical Constituents Of S Fusiformementioning

confidence: 99%

Bioactivities of the Popular Edible Brown Seaweed Sargassum fusiforme: A Review

Wang,

Huang,

et al. 2023

J. Agric. Food Chem.

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Sargassum fusiforme has a wide range of active constituents (such as polysaccharides, sterols, polyphenols, terpenes, amino acids, trace elements, etc.) and is an economically important brown algae with a long history. In recent years, S. fusiforme has been intensively studied and has attracted wide attention in the fields of agriculture, environment, medicine, and functional food. In this review, we reviewed the current research status of S. fusiforme at home and abroad over the past decade by searching Web of science, Google Scholar, and other databases, and structurally analyzed the active components of S. fusiforme, and on this basis, we focused on summarizing the cutting-edge research and scientific issues on the role of various active substances in S. fusiforme in exerting antioxidant, anti-inflammatory, antitumor, antidiabetic, immunomodulatory, antiviral antibacterial, and anticoagulant effects. The mechanisms by which different substances exert active effects were further summarized by exploring different experimental models and are shown visually. It provides a reference to promote further development and comprehensive utilization of S. fusiforme resources.

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“…Although human experiments on the effects of fucoxanthin are lacking, animal experiments have shown evidence of anticancer effects. Oral administration of fucoxanthin has revealed no toxicity and mutagenicity (13)(14)(15)(16)(17). Apart from anticancer effects, fucoxanthin has also been demonstrated to have other health beneficial effects (18)(19)(20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Gemcitabine‑fucoxanthin combination in human pancreatic cancer cells

Hassouna

et al. 2023

Biomed Rep

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Gemcitabine is a chemotherapeutic agent for pancreatic cancer treatment. It has also been demonstrated to inhibit human pancreatic cancer cell lines, MIA PaCa-2 and PANC-1. The aim of the present study was to investigate the suppressive effect of fucoxanthin, a marine carotenoid, in combination with gemcitabine on pancreatic cancer cells. MTT assays and cell cycle analysis using flow cytometry were performed to study the mechanism of action. The results revealed that combining a low dose of fucoxanthin with gemcitabine enhanced the cell viability of human embryonic kidney cells, 293, while a high dose of fucoxanthin enhanced the inhibitory effect of gemcitabine on the cell viability of this cell line. In addition, the enhanced effect of fucoxanthin on the inhibitory effect of gemcitabine on PANC-1 cells was significant (P<0.01). Fucoxanthin combined with gemcitabine also exerted significant enhancement of the anti-proliferation effect in MIA PaCa-2 cells in a concentration dependent manner (P<0.05), compared with gemcitabine treatment alone. In conclusion, fucoxanthin improved the cytotoxicity of gemcitabine on human pancreatic cancer cells at concentrations that were not cytotoxic to non-cancer cells. Thus, fucoxanthin has the potential to be used as an adjunct in pancreatic cancer treatment.

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Toxicological assessment of Xanthigen® nutraceutical extract combination: Mutagenicity, genotoxicity and oral toxicity

Abstract: Graphical abstract

Cited by 9 publications

References 20 publications

The Critical Studies of Fucoxanthin Research Trends from 1928 to June 2021: A Bibliometric Review

The Critical Studies of Fucoxanthin Research Trends from 1928 to June 2021: A Bibliometric Review

Bioactivities of the Popular Edible Brown Seaweed Sargassum fusiforme: A Review

Gemcitabine‑fucoxanthin combination in human pancreatic cancer cells

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