Toxicological and pesticidal studies on novel bioactive sulfonamide imine organotin(IV) complexes

Abstract

Toxicological, pesticidal and stereochemical aspects of organotin(IV) complexes with a sulfonamide imine ligand having an N ∩ N donor system are described with the support of elemental analysis, IR, UV, 1 H NMR, 13 C NMR and 119 Sn NMR spectroscopy. The spectral data suggest that the ligand acts in a monobasic bidentate manner coordinating through the nitrogen atom. The complexes have been characterized on the basis of molecular weight determinations, conductivity measurements, and magnetic measurements. The isolated products are coloured solids, soluble in dimethylsulfoxide, dimethylformamide (DMF) and methanol. All the complexes are monomeric in nature, as indicated by their molecular weight determinations. Conductivity measurements in dry DMF show them to be non-electrolytes. From the analyses of these studies the donor sites of the ligand are located and the geometries of the donor environment around the tin(IV) acceptor centres proposed. The ligand and its metal complexes are tested in vitro against a number of pathogenic fungal and bacterial strains and the findings are discussed. Emphasis has been given to the nematicidal properties.

Synthesis, characterisation and X-ray structures of diorganotin(IV) and iron(III) complexes of dianionic terdentate Schiff base ligands

“…The ligands and tin complexes were also studied in solution by 1 H and 13 C NMR spectroscopy and, in the case of the tin complexes, by 119 Sn NMR spectroscopy.…”

“…These values are in agreement with those determined in the solid state (Tables 3 and 5), confirming that the coordination polyhedron present in the solid state persists in chloroform solution. The 13 C NMR spectra of the complexes contain the signals for the different carbon atoms. The signal due to the azomethine is observed at low field (145.…”

“…In particular, complexes with Schiff bases derived from amino acids [4][5][6] and ONO and NNO dianionic terdentate Schiff bases have been widely reported [6][7][8][9][10][11][12]. Recently, the synthesis and toxicological activity of organotin(IV) compounds with a sulfonamide imine ligand have been also described, although crystal structures for these compounds were not reported [13].…”

Synthesis, characterization, antimicrobial, and DNA cleavage evaluation of some organotin(IV) complexes derived from ligands containing the 1H-indole-2,3-dione moiety

“…The bands corresponding to asymmetric and symmetric modes of (Sn-C) stretching vibrations appear at 597 and 520 cm -1 , respectively. The band observed in the spectra of the complexes at 1225-1182 cm -1 may be assigned to Sn-CH 3 stretching vibrations (Jain and Singh, 2003). The most significant IR absorption frequencies, along with the relative assignments of the ligands and their Sn(IV) complexes, are listed in Table 1.…”

Synthetic, structural and biological studies of organotin(IV) complexes of schiff bases derived from pyrrol-2-carboxaldehyde

“…The value of G 119 Sn spectra reflects the coordination number of the nucleus in the corresponding metal complexes [29][30][31]. In general, 119 Sn chemical shifts move to lower frequency with increasing coordination number of the nuclei.…”