Toxicological and nutritional status of trace elements in hair of women with in vitro fertilization (IVF) pregnancy and their 9-month-old children

Skalny, Anatoly V.; Tinkov, Alexey A.; Bohan, Tatiana G.; Shabalovskaya, Marina B.; Владимировна, Терехина Ольга; Leshchinskaia, Svetlana B.; Агаркова, Л. А.; Нотова, С. В.; Skalnaya, Margarita G.; Kovas, Yulia

doi:10.1016/j.reprotox.2018.10.004

Cited by 5 publications

(7 citation statements)

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“…Two periods of a significant increase in the level of these metals in bio substrate were found: the first between 2 and 9 years of age; the second is from 60 to 85 years. Unfortunately, the quantitative shifts of other metals were not analyzed, although in children aged 2-9 years they could be identical to those given by the authors of the study in question [1] Table 2.…”

Section: Introductionmentioning

confidence: 75%

“…

The present article comments on the results of hair spectrometry in pregnant and 9-month-old babies born to these women published in the Reproductive Toxicology journal ( 2018) [1]. The author of this article gives a different explanation of the data obtained by the aforesaid study in view of the idea of metal-ligand homeostasis in the epidermis as a self-organized criticality phenomenon.

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mentioning

confidence: 87%

“…For convenience, the above differences can be presented as follows The observed shifts in the metal-ligand homeostasis (MLH) of the epidermis in their direction are practically identical (except Fe) to the hair, spectrometry results of the authors referred to in [1] Table 2. It should be noted that the concentration values of metals in Table 1 are presented as mean with confidence intervals (bootstrap-method), and in Table 2 -as median.…”

Section: Introductionmentioning

confidence: 99%

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Revisiting the Role of Membrane ATPases (P-Type) in Metal-Ligand Homeostasis of Epidermal Cells

2019

BJSTR

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Section: Introductionmentioning

confidence: 75%

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confidence: 87%

Section: Introductionmentioning

confidence: 99%

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Revisiting the Role of Membrane ATPases (P-Type) in Metal-Ligand Homeostasis of Epidermal Cells

2019

BJSTR

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“…Five studies ( 23 , 26 , 29 – 31 ) investigated heavy metals and metalloids in hair samples of women undergoing IVF. In a study to examine the heavy metals and metalloids status in hair samples of women with IVF pregnancy and their 9-month-old children, Skalny et al ( 29 ) found out that women with IVF pregnancy demonstrated significantly high hair As, Hg, Li levels and their children also had significantly elevated hair Hg and Mo concentrations compared to control ( 30 ). Similarly, another case-control study by Skalny et al ( 30 ) demonstrated that IVF pregnancy correlated significantly with elevated hair levels of As ( p < 0.05) suggestive of arsenic overload in IVF patients ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Heavy metals and metalloids exposure and in vitro fertilization: Critical concerns in human reproductive medicine

Obasi

Frazzoli

Orisakwe

2022

Front. Reprod. Health

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Exposures to heavy metals and metalloids have been associated with decreased fecundity and fertility in couples conceiving via assisted reproduction. Heavy metals and metalloids can alter the homeostasis of critical hormones controlling sexual maturation by binding to critical hormones and receptors. This may disrupt the time course of sexual maturation directly or indirectly affecting reproductive competence in males and females. The present review aims to provide a summarized overview of associations between heavy metal exposure, reproductive concerns, and IVF outcomes. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) in Google Scholar, Scopus, EMBASE and PubMed databases. Initial search produced 1,351 articles from which 30 articles were eligible to be included in the systematic review. From our results, 16 articles reported associations between selected heavy metals and IVF outcomes, while 14 articles summarized the role of heavy metals in reproductive concerns. For the studies on IVF outcomes, different human samples were examined for heavy metals. Heavy metals and metalloids (Pb, Hg, Cd, Cr, Mn, As) correlated negatively with oocyte fertilization/pregnancy rates in hair, follicular fluid, serum, urine and seminal plasma samples, while Cd and Hg in whole blood samples showed no associations. For the studies on reproductive concerns, high levels of heavy metals/metalloids were implicated in the following conditions: infertility (Cd, Pb, Ba, U), spontaneous abortion/miscarriage (Pb, Cd, Sb), congenital heart disease (Al, Mg, Cd), PCOS (As, Cd, Hg, Pb), endometriosis (Pb) and uterine leiomyomata (Hg). Taken together, the results of our study suggest that the impact of heavy metals and metalloids exposure on reproductive health may contribute to the failure rates of in vitro fertilization.

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“…Other trace elements and minerals including copper, magnesium [20], iron [21], calcium [22], also play a role in normal pregnancy and fetal development. A significant relationship has been demonstrated between trace element status and risk of infertility [23], as well as pre-eclampsia [24] and other adverse outcomes [25]. It has been also noted that altered trace element status may be also involved in pathogenesis of postpartum depression [26].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Maternal Overweight on Hair Essential Trace Element and Mineral Content in Pregnant Women and Their Children

Skalny

Tinkov

Bohan

et al. 2019

Biol Trace Elem Res

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The aim of the present study was to investigate hair essential trace elements and mineral levels in 105 pregnant normal-weight (control) and 55 overweight and obese women in the third trimester of pregnancy, as well as in their children at the age of 9 months. The hair essential trace elements and mineral levels were assessed using inductively-coupled plasma mass-spectrometry. Overweight pregnant women had significantly reduced Cr (-24%; p = 0.047) and Zn (-13%; p = 0.008) content, as well as elevated hair Na and K levels as compared to the controls. Children from overweight and obese mothers had lower hair Mo (-18%; p = 0.017), Se (-8%; p = 0.043), and V (-24%; p = 0.028) levels, as well as elevated Sr content (19%; p = 0.025). Correlation analysis revealed a significant relationship between maternal and child hair levels of Co (r = 0.170; p=0.038), Cu (r = 0.513; p<0.001), Mn (r = 0.240; p=0.003), and Na (r = 0.181; p=0.027) in the whole sample. Pre-pregnancy maternal body mass index (BMI) positively correlated with maternal hair K (r = 0.336; p<0.001) and Na (r = 0.212; p=0.008), and negatively correlated with V (r =-0.204; p=0.011) and Zn (r =-0.162; p=0.045) levels. The results indicate that impaired trace element and mineral metabolism may play a role in the link between maternal obesity, complications of pregnancy and child's postnatal development. Hypothetically, dietary improvement may be used as a tool to reduce these risks. However, further experimental and clinical studies are required to investigate the relationship between obesity and trace element metabolism in pregnancy.

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Toxicological and nutritional status of trace elements in hair of women with in vitro fertilization (IVF) pregnancy and their 9-month-old children

Cited by 5 publications

References 61 publications

Revisiting the Role of Membrane ATPases (P-Type) in Metal-Ligand Homeostasis of Epidermal Cells

Revisiting the Role of Membrane ATPases (P-Type) in Metal-Ligand Homeostasis of Epidermal Cells

Heavy metals and metalloids exposure and in vitro fertilization: Critical concerns in human reproductive medicine

The Impact of Maternal Overweight on Hair Essential Trace Element and Mineral Content in Pregnant Women and Their Children

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