Toxicologic effect and transcriptome analysis for short-term orally dosed enrofloxacin combined with two veterinary antimicrobials on rat liver

Luan, Yehui; Zhao, Junjie; Han, Hongfei; Shen, Jianzhong; Tang, Shusheng; Cheng, Lin

doi:10.1016/j.ecoenv.2021.112398

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…75 Studies of associated toxicity (enrofloxacin combined with colistin and QCT) in risk assessment are also mentioned. 82 QCT-induced apoptosis was mainly caused by oxidative stress and DNA damage induction, 83 which also verified that QCT-induced immunotoxicity was also mediated by both of these causes. 84 ■ CONCLUSION According to the five QdNOs mentioned above, the main metabolic pathways are N → O group reduction and hydroxylation reactions, and the main metabolites are monodeoxy, dideoxy, and hydroxyl substituents.…”

Section: Chemicalsupporting

confidence: 53%

“…In cell culture, joint treatments (oxytetracycline and quinocetone) was reported to induce synergistic cytotoxicity, increasing hepatotoxicity in mice . Studies of associated toxicity (enrofloxacin combined with colistin and QCT) in risk assessment are also mentioned . QCT-induced apoptosis was mainly caused by oxidative stress and DNA damage induction, which also verified that QCT-induced immunotoxicity was also mediated by both of these causes. …”

Section: Introductionmentioning

confidence: 73%

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Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides

An,

Li,

et al. 2024

Chem. Res. Toxicol.

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Quinoxaline 1,4-di-N-Oxides (QdNOs) have been used as synthetic antimicrobial agents in animal husbandry and aquaculture. The metabolism and potential toxicity have been also concerns in recently years. The metabolism investigations showed that there were 8 metabolites of Carbadox (CBX), 34 metabolites of Cyadox (CYA), 33 metabolites of Mequindox (MEQ), 35 metabolites of Olaquindox (OLA), and 56 metabolites of Quinocetone (QCT) in different animals. Among them, Cb3 and Cb8, M6, and O9 are metabolic residual markers of CBX, MEQ and OLA, which are associated with N → O reduction. Toxicity studies revealed that QdNOs exhibited severe tumorigenicity, cytotoxicity, and adrenal toxicity. Metabolic toxicology showed that toxicity of QdNOs metabolites might be related to the N → O group reduction, and some metabolites exhibited higher toxic effects than the precursor, which could provide guidance for further research on the metabolic toxicology of QdNOs and provide a wealth of information for food safety evaluation.

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Section: Chemicalsupporting

confidence: 53%

Section: Introductionmentioning

confidence: 73%

Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides

An,

Li,

et al. 2024

Chem. Res. Toxicol.

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“…While using antibiotics, such as ENR, to prevent bacterial diseases in the brooding stage, it is easy to produce bacterial metabolite LPS in the body ( Li et al, 2019a ; Guo et al, 2020 ). Previous reports have reported that both ENR and LPS mediate hepatotoxicity and cause liver damage ( Antonissen et al, 2017 ; Luan et al, 2021 ; Anwar and Mabrouk, 2023 ; Wang et al, 2023 ). It has been confirmed that MRGD is a traditional Chinese medicine compound with hepatoprotective activity ( Wang et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Modified rougan decoction attenuates hepatocyte apoptosis through ameliorating mitochondrial dysfunction by upregulated SIRT1/PGC-1α signaling pathway

Wang

Ding

et al. 2023

Poultry Science

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“…Previous studies on joint CAR toxicity have focused primarily on other pesticides [38,39] and similar studies on ENF have focused on other veterinary drugs [40,41], while few studies have examined the combination of pesticides and veterinary drugs. However, as most people consume fruits, vegetables, milk, and meat every day, an examination of potential combined effects of pesticides and veterinary drugs is important for comprehensive safety assessment.…”

Section: Discussionmentioning

confidence: 99%

Antagonistic Effects of Enrofloxacin on Carbendazim-Induced Developmental Toxicity in Zebrafish Embryos

Fan

Zhang

et al. 2021

Toxics

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Carbendazim (CAR) and enrofloxacin (ENF) are frequently detected in fruits and meat products, respectively. Since most people consume fruits, vegetables, and meat products, combined exposure is possible, necessitating further evaluation of toxic interactions. In this study, the developmental toxicity of separate and combined exposure was examined in zebrafish embryos. Carbendazim exposure at 0.79 mg/L and above significantly affected developmental parameters, while enrofloxacin alone had no substantial effects on these developmental parameters within the selected concentration range (0.10–0.40 mg/L). Surprisingly, ENF antagonized the CAR-evoked reduction in the 48 hpf (hours post-fertilization) hatching rate and the increases in the 96 hpf malformation and lethality rates. The results revealed that the antagonism might be associated with reciprocal effects of these compounds on metabolism-related genes, such as cyp7a1 and apoa1a. These results reveal a complex interaction between ENF and CAR on metabolic regulation during development and highlight the importance of combined assessment for agents with the potential for simultaneous exposure.

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Toxicologic effect and transcriptome analysis for short-term orally dosed enrofloxacin combined with two veterinary antimicrobials on rat liver

Cited by 8 publications

References 29 publications

Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides

Advances in Metabolism and Metabolic Toxicology of Quinoxaline 1,4-Di-N-oxides

Modified rougan decoction attenuates hepatocyte apoptosis through ameliorating mitochondrial dysfunction by upregulated SIRT1/PGC-1α signaling pathway

Antagonistic Effects of Enrofloxacin on Carbendazim-Induced Developmental Toxicity in Zebrafish Embryos

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