Toxicologic assessment of Paecilomyces tenuipes in rats: Renal toxicity and mutagenic potential

Hwan, Jeong; Yun, Jun Won; Cho, Eun Young; Kim, Seung Hyun; Kim, Yun Soon; Kim, Woo Ho; Park, Jae Hak; Son, Woo Chan; Kim, Mi Kyung; Kang, Byeong Cheol

doi:10.1016/j.yrtph.2014.09.003

Cited by 16 publications

(8 citation statements)

References 27 publications

(29 reference statements)

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“…Since traditional medicines are often perceived as "natural" and therefore free from side effects (Markman, 2002;Shin et al, 2013), a comprehensive analysis of safety issues for the majority of herbal medicine has not been fully established although we recently found that various beneficial herbs have toxic side effects (Che et al, 2014(Che et al, , 2015Yun et al, 2015a). It has been reported that C. racemosa induced the acute liver injury (Enbom et al, 2014;Muqeet Adnan et al, 2014;NIDDK, 2015).…”

Section: Introductionmentioning

confidence: 97%

Pre-clinical in vitro and in vivo safety evaluation of Cimicifuga heracleifolia

Yun

You

Kim

et al. 2015

Regulatory Toxicology and Pharmacology

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Section: Introductionmentioning

confidence: 97%

Pre-clinical in vitro and in vivo safety evaluation of Cimicifuga heracleifolia

Yun

You

Kim

et al. 2015

Regulatory Toxicology and Pharmacology

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“…In addition, it is easy to obtain them from many grocery stores without having a prescription [ 14 – 20 ]. However, it has been demonstrated that many traditional beneficial herbs have genotoxic or systemic (liver and kidney) toxicity [ 21 – 25 ]. Thus, it is necessary to conduct comprehensive safety analysis under strict guidelines for herbal medicine available on the market.…”

Section: Introductionmentioning

confidence: 99%

Assessment of acute, 14-day, and 13-week repeated oral dose toxicity of Tiglium seed extract in rats

Yun

Kwon

Kim

et al. 2018

BMC Complement Altern Med

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BackgroundSeed of mature Croton tiglium Linne, also known as Tiglium seed (TS), has been widely used as a natural product due to its several health beneficial properties including anti-tumor and antifungal activities. Despite its ethnomedicinal beneficial properties, toxicological information regarding TS extract, especially its long-term toxicity, is currently limited. Therefore, the objective of the present study was to evaluate acute and subchronic toxicity of TS extract in rats after oral administration following test guidelines of the Organization for Economic Cooperation and Development (OECD).MethodsToxicological properties of TS extract were evaluated by toxicity assays to determine its single-dose acute toxicity (125, 250, 500, 1000, or 2000 mg/kg), 14-day repeated-dose toxicity (125, 250, 500, 1000, or 2000 mg/kg) and 13-week repeated-dose toxicity (31.25, 62.5, 125, 250, and 500 mg/kg) in Sprague-Dawley rats and F344 rats. Hematological, serum biochemical, and histopathological parameters were analyzed to determine its median lethal dose (LD50) and no-observed-adverse-effect-level (NOAEL).ResultsOral single dose up to 2000 mg/kg of TS extract resulted in no mortalities or abnormal clinical signs. In 13-week toxicity study, TS extract exhibited no dose-related changes (mortality, body weight, food/water consumption, hematology, clinical biochemistry, organ weight, or histopathology) at dose up to 500 mg/kg, the highest dosage level suggested based on 14-day repeat-dose oral toxicity study.ConclusionAcute oral LD50 of TS extract in rats was estimated to be greater than 2000 mg/kg. NOAEL of TS extract administered orally was determined to be 500 mg/kg/day in both male and female rats. Results from these acute and subchronic toxicity assessments of TS extract under Good Laboratory Practice regulations indicate that TS extract appears to be safe for human consumption.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2315-5) contains supplementary material, which is available to authorized users.

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“…However, there are no available facts of degree of excellence, reliability and efficacy of majority of the generally used herbal recipes. Recently it has been established that, poisonous side effects combined quite with diverse beneficial herbs [6][7][8]. These features need to consider among the visible effects of absolute examinations carried out for the toxicity assessment of these folk medicines and herbal recipes.…”

Section: Introductionmentioning

confidence: 99%