Toxicokinetics of Cadmium in Lactating and Nonlactating Ewes after Oral and Intravenous Administration

Houpert, P.; Federspiel, Brigitte; Milhaud, G.

doi:10.1006/enrs.1996.3690

Cited by 23 publications

(13 citation statements)

References 31 publications

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“…Cadmium uptake is competitively inhibited by zinc in freshly isolated rabbit renal cortical cells (Gachot & Poujeol 1992). These in vitro results, confirming negative interactions between accumulated cadmium and exposure to minerals, are in agreement with previous in vivo results in ewes (Houpert et al 1997) and other experimental animals (Brzoska & Moniuszko-Jakoniuk 2001;Noe¨l et al 2004). In male rats, the rate of gastrointestinal absorption of Cd is decreased by supplementation of the drinking water with a 'non-toxic' dose of manganese (Sarhan et al 1986).…”

Section: Discussionsupporting

confidence: 92%

Cadmium accumulation and interactions with zinc, copper, and manganese, analysed by ICP-MS in a long-term Caco-2 TC7 cell model

et al. 2006

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The influence of long-term exposure to cadmium (Cd) on essential minerals was investigated using a Caco-2 TC7 cells and a multi-analytical tool: microwave digestion and inductively coupled plasma mass spectrometry. Intracellular levels, effects on cadmium accumulation, distribution, and reference concentration ranges of the following elements were determined: Na, Mg, Ca, Cr, Fe, Mn, Co, Ni, Cu, Zn, Mo, and Cd. Results showed that Caco-2 TC7 cells incubated long-term with cadmium concentrations ranging from 0 to 10 micromol Cd/l for 5 weeks exhibited a significant increase in cadmium accumulation. Furthermore, this accumulation was more marked in cells exposed long-term to cadmium compared with controls, and that this exposure resulted in a significant accumulation of copper and zinc but not of the other elements measured. Interactions of Cd with three elements: zinc, copper, and manganese were particularly studied. Exposed to 30 micromol/l of the element, manganese showed the highest inhibition and copper the lowest on cadmium intracellular accumulation but Zn, Cu, and Mn behave differently in terms of their mutual competition with Cd. Indeed, increasing cadmium in the culture medium resulted in a gradual and significant increase in the accumulation of zinc. There was a significant decrease in manganese from 5 micromol Cd/l exposure, and no variation was observed with copper.

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Section: Discussionsupporting

confidence: 92%

Cadmium accumulation and interactions with zinc, copper, and manganese, analysed by ICP-MS in a long-term Caco-2 TC7 cell model

et al. 2006

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“…The same proteins have been identified in mushroom, beans, soya beans, cabbage, wheat, and several other plants (Tjell et al 1983). Studies have shown that cadmium transfer via milk was low in rats and mice (Lucis et al 1972;Tanaka et al 1972), sheep (Houpert et al 1997), cattle (Smith et al 1991), and humans (Biego et al 1998). The range of cadmium concentrations in milk was thus reportedly high, ranging from 1 to 30 ppb (Grawe and Oskarsson 2000) with many of the values being much higher (up to 15 times higher) than the Drinking Water Guideline Values (DWGVs).…”

Section: Airmentioning

confidence: 79%

Cadmium levels in Europe: implications for human health

Pan

Plant

Voulvoulis

et al. 2009

Environ Geochem Health

334

144

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In this study we used the Forum of European Geological Surveys geochemical baseline data to examine the distribution of cadmium (Cd) in Europe, with a particular reference to the international soil and water guideline values. The highest cadmium levels were found to occur in topsoil and to follow closely the distribution of P(2)O(5), suggesting that the contamination was from the use of rock phosphate fertilizer in intensive arable agriculture. In terms of human health impacts, food (up to several hundred microg/day) was found as the only major route of exposure to Cd for the non-smoking general population. It appeared that low levels of chronic exposure to Cd resulted in completely different human health impacts than those high levels that had caused the 'itai-itai' disease. Some correlations were suggested between cadmium levels and the age-adjusted prostate or breast cancer rates distributed in the European countries under study.

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“…In mammals, lactation is characterized by the increase of Cd intestinal absorption as well as its retention in different tissues of the maternal organism [10][11][12] . The increase of metal retention is principally noted in mammary tissue.…”

Section: Discussionmentioning

confidence: 99%

Lactational Transfer of Cadmium from <i> Meriones shawi shawi</i> Mothers to Their Pups and Its Effects on Calcium Homeostasis and Bone Calcium in Pups

Haouem

Sakly²

2005

Ann Nutr Metab

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Cadmium (Cd) was given to Meriones shawi shawi dams in the diet (1 g CdCl₂/1.5 kg of diet) from day 1 to day 21 of lactation. Pups were killed at 5, 10, 14 and 21 days of lactation. Thereafter, liver, kidney, femur and stomach content were removed and plasma was collected to element analyses. Cd in stomach content, kidney, liver and femur and calcium (Ca) in stomach content, femur and plasma were determined in pups by atomic absorption spectrophotometer. The results indicate that Cd was transferred to the suckling and it was detected in the liver, the kidney and the femur from the 5th, the 10th and the 14th days of age, respectively. Stomach content of Ca was increased significantly from the 10th day to the end of lactation, whereas Ca levels increase in plasma and femur only at day 10 of lactation.

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Toxicokinetics of Cadmium in Lactating and Nonlactating Ewes after Oral and Intravenous Administration

Cited by 23 publications

References 31 publications

Cadmium accumulation and interactions with zinc, copper, and manganese, analysed by ICP-MS in a long-term Caco-2 TC7 cell model

Cadmium accumulation and interactions with zinc, copper, and manganese, analysed by ICP-MS in a long-term Caco-2 TC7 cell model

Cadmium levels in Europe: implications for human health

Lactational Transfer of Cadmium from <i> Meriones shawi shawi</i> Mothers to Their Pups and Its Effects on Calcium Homeostasis and Bone Calcium in Pups

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