Lactational Transfer of Cadmium from &lt;i&gt; Meriones shawi shawi&lt;/i&gt; Mothers to Their Pups and Its Effects on Calcium Homeostasis and Bone Calcium in Pups

Haouem, Samir; Sakly, R

doi:10.1159/000087296

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…Thus, the purpose of the present study was to elucidate the possible molecular mechanism by which Cd can influence the lactational transfer, absorption, and distribution of Zn in the suckling rat organism. Although Cd transfer via the milk has been reported to be low in mice and rats [25], the present study, in agreement with the results of the preceding studies [2,26], confirms the importance of lactational transfer of Cd. In fact, Cd was found in the stomach content of contaminated suckling rats, but in control pups, this metal was not detected until the end of the experimental period.…”

Section: Discussionsupporting

confidence: 93%

Changes of the mRNA Expression Pattern of Zn Transporters: a Probable Mechanism for Cadmium Retention and Zinc Redistribution in the Suckling Rat Tissues

Chemek

Boughammoura

Mimouna

et al. 2015

Biol Trace Elem Res

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The present study was conducted to provide potential mechanism that may be responsible for Cd retention and Cd-induced Zn redistribution in tissues of suckling rat. For this purpose, suckling rats from mother receiving either tap water, Cd, or Cd + Zn during lactation period were sacrificed on postnatal day (PND) 14 and PND 21 for performing chemical and molecular analysis. Our results show that Cd exposure, although it does not affect the milk consumption, it clearly alters the lactational transfer, absorption, and distribution of Zn in the suckling rat organism. At the molecular level, Cd caused upregulation of ZIP 3, ZIP 4, and ZIP 8 gene expressions in the mammary gland of mothers rats and in the intestine of their pups but decreased the expression of ZnT 2 and ZnT 4 only in the mammary tissue at PND 14 and PND 21. Zn supply reversed the Cd-induced decrease in the neonatal Zn apparent absorption and restores the gastrointestinal, brain, and plasma levels of this essential element in the suckling rat organism at PND 14 and PND 21. Also, with this treatment, the gene expressions of ZnT 1 in the mammary gland and ZnT 4 in the neonatal intestine were found to be upregulated at PND 21. Furthermore, our results show that Cd or Cd + Zn treatment increase the neonatal hepatic MTs accumulation at PND 14 only. These results imply that the downregulation of ZnT as well as the overexpression of ZIP transporters, in responses to the Zn depletion induced by Cd in the tissues of lactating rat and their offspring, play a major role in Cd accumulation and Zn redistribution in tissues of suckling rat.

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Section: Discussionsupporting

confidence: 93%

Changes of the mRNA Expression Pattern of Zn Transporters: a Probable Mechanism for Cadmium Retention and Zinc Redistribution in the Suckling Rat Tissues

Chemek

Boughammoura

Mimouna

et al. 2015

Biol Trace Elem Res

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“…Given that at PND 17 is the moment when the offspring for the first time consume the solid food together with milk and at PND 19 the first day of intake of drinking water occurs [38], the present study, in agreement with previous investigations [39,40], confirms the importance of lactational transfer of Cd. In fact, in Cd and Cd+Zn-exposed animals, Cd was accumulated in the testis at different postnatal ages and reached conspicuous concentrations at PND 21, whereas no Cd could be detected in the control and Zn-exposed animals.…”

Section: Discussionsupporting

confidence: 92%

Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Chemek

Mimouna

Boughammoura

et al. 2016

Reproductive Toxicology

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Highlights Effects of Cd and Zn on testicular development were assessed. Cd accumulation and Zn depletion in testis during lactation were noted. Cd-induced abnormal seminiferous tubules and a plasmatic testosterone decrease. Zn supply induced a significant protection against Cd toxicity. Cd toxicity observed in pups is mediated by disruption of maternal Zn metabolism. *Research Highlights AbstractTo assess the effects of exposure to Cd and Zn on rat testicular development, offspring, from mothers receiving either tap water, Cd, Zn or Cd+Zn during gestation and lactation periods, were observed on gestational day (GD) 20 and on postnatal days (PND) 12, 21 and 35. During gestation, Cd induced maternal hypozincemia and less transfer of Zn to the fetus. During lactation, progressive Cd accumulation and Zn depletion in testis at PND12 and PND21 werenoted. An increase of abnormal seminiferous tubules and a decrease in testis weight and plasmatic testosterone concentration were also observed at PND21 and PND35 respectively. Interestingly, Zn supply induced a significant protection against Cd toxicity. These results suggest that the toxic effects of Cd observed during development are mediated by the disruption of Zn metabolism, which is established in mothers during pregnancy causing Zn deficiency in fetuses and continues to become more pronounced during lactation.

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“…Cd determination: Cadmium concentrations in the liver, kidneys and testes were determined as described in our previous study 12 . Briefly, samples of the liver, kidneys and testes were dried to a constant weight.…”

Section: Methodsmentioning

confidence: 99%

Effect of Cadmium on Lipid Peroxidation and on Some Antioxidants in the Liver, Kidneys and Testes of Rats Given Diet Containing Cadmium-polluted Radish Bulbs

Haouem

Hani

2013

J Toxicol Pathol

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The aim of this study was to examine the effects of cadmium (Cd), incorporated in radish bulbs, on malondialdehyde and glutathione levels and on superoxide dismutase activity in the liver, kidneys and testes of male rats. The control animals were given diet containing ordinary radish bulbs for 4, 8 and 12 weeks, while contaminated animals were given diet containing Cd-polluted radish bulbs (1.1 mg Cd/g of diet) for the same periods as in the controls. At each time point, rats were euthanized and the liver, kidneys and testes were removed. The results indicated that the body weight gain of contaminated rats was identical to that of the control rats. Cd concentrations in the liver, kidneys and testes increased significantly and gradually from the 4th to 12th week of treatment. Malondialdehyde concentrations decreased significantly in the liver and increased significantly in the kidneys and testes after 12 weeks of treatment, while glutathione levels increased significantly in the liver, and decreased significantly in the kidneys and testes at the same time. No changes were observed in SOD activity in the liver, while in the kidneys and testes, this activity was increased after 12 weeks of treatment as compared with the control rats.

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Lactational Transfer of Cadmium from <i> Meriones shawi shawi</i> Mothers to Their Pups and Its Effects on Calcium Homeostasis and Bone Calcium in Pups

Cited by 6 publications

References 38 publications

Changes of the mRNA Expression Pattern of Zn Transporters: a Probable Mechanism for Cadmium Retention and Zinc Redistribution in the Suckling Rat Tissues

Changes of the mRNA Expression Pattern of Zn Transporters: a Probable Mechanism for Cadmium Retention and Zinc Redistribution in the Suckling Rat Tissues

Protective role of zinc against the toxicity induced by exposure to cadmium during gestation and lactation on testis development

Effect of Cadmium on Lipid Peroxidation and on Some Antioxidants in the Liver, Kidneys and Testes of Rats Given Diet Containing Cadmium-polluted Radish Bulbs

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