Toxicokinetics in fish: Accumulation and elimination of six chlorobenzenes by guppies

Könemann, Hans; Leeuwen, Cornelis van

doi:10.1016/0045-6535(80)90150-2

Cited by 217 publications

(96 citation statements)

References 13 publications

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“…Simultaneous estimation of rate constants from consecutive exposure and elimination studies has been used only by a limited number of authors for the one-compartment model (34). For two-compartment model studies (30,(35)(36) such an approach has not yet been used. The recent availability of user-friendly computer programs with numerical techniques for the solution of the differential equations enables simultaneous parameter estimation for compartment models even with time-variable water concentrations (23,(37)(38).…”

Section: Methodsmentioning

confidence: 99%

“…The parameter estimates for the elimination rate constants of the six PAHs in Asellus show a decreasing trend with increasing Kow. Elimination rate constants of many organic compounds decrease with Kow, and double logarithmic regression relationships have been reported for different classes of compounds in various groups of organisms (16,32,35,49,51). Relationships reported for PAHs in mollusks, daphnids (49), fish (48), amphipods (16), and other species have been summarized in Van Brummelen et al (3).…”

Section: Bcf In Relation To Kow the Bcfs Observed For Pahs In A Aqumentioning

confidence: 99%

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Toxicokinetics and Bioconcentration of Polycyclic Aromatic Hydrocarbons in Freshwater Isopods

Hattum¹,

Montañés²

1999

Environ. Sci. Technol.

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A novel method based on a first-order two-compartment model was used to determine the bioconcentration and toxicokinetic rate constants of six different polycyclic aromatic hydrocarbons (PAHs) in the freshwater isopod Asellus aquaticus, a common species in most European freshwater systems. Numerical integration and iterative parameter estimation techniques were applied to account for time-varying aqueous exposure concentrations. All PAHs exhibited a rapid uptake. Monophasic elimination patterns were observed for benzo[e]pyrene and benzo[a]pyrene (biological half-life t 0.5 : 7-8 days). For the other PAHs (anthracene, phenanthrene, pyrene, benzo[ghi]perylene) typical biphasic patterns were encountered with rapidly (t 0.5 : 0.6-2 days) and slowly (t 0.5 : 99to>1000 days) exchanging compartments. Some PAHs (pyrene and benzo[ghi]perylene) will hardly be eliminated during the normal life span of the organism. Bioconcentration factors (log BCF, wet weight; derived from rate constants) increased with molecular weight and K ow (n-octanol/water partition coefficient) from 2.6 L kg -1 (anthracene) to 5.7 L kg -1 (benzo-[ghi]perylene). A linear relationship was observed between log BCF and log K ow. It is argued that biotransformation of PAHs in freshwater isopods seems to play a minor role and that this species may be suitable for the assessment of the bioavailability of PAHs in littoral freshwater environments.

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Section: Methodsmentioning

confidence: 99%

Section: Bcf In Relation To Kow the Bcfs Observed For Pahs In A Aqumentioning

confidence: 99%

Toxicokinetics and Bioconcentration of Polycyclic Aromatic Hydrocarbons in Freshwater Isopods

Hattum¹,

Montañés²

1999

Environ. Sci. Technol.

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“…Other species may be used but the test procedure may have to be adapted to provide suitable test conditions. The (13) Although not generally recommended, if a solvent or solubilising agent is used the organic carbon originating from this agent should be added to the organic carbon from the test substance to evaluate the concentration of organic carbon in the test vessels.…”

mentioning

confidence: 99%

“…The solvent's contribution (together with the test substance) to the overall content of organic carbon in the test water should be known. Throughout the test, the concentration of total organic carbon in the test vessels should not exceed the concentration of organic carbon originating from the test substance, and solvent or solubilising agent (13 …”

mentioning

confidence: 99%

“…The aqueous exposure test is most appropriately applied to stable organic chemicals with log K OW values between 1.5 and 6.0 (13) (2) Sometimes denoted by P OW ; determined by a shake-flask method in TG 107 (3), an HPLC method in TG 117 (4) and a slow-stirring method in TG 123 (5). The generator-column technique is occasionally used for the determination of log K OW .…”

mentioning

confidence: 99%

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Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure

2012

OECD Guidelines for the Testing of Chemicals, Section 3

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Accumulation and Elimination Kinetics of Herbicides Butachlor, Thiobencarb and Chlomethoxyfen byAristichthys nobilis

1997

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: Bioconcentration kinetics of three major paddy-Ðeld herbicides, butachlor, thiobencarb and chlomethoxyfen were investigated by accumulation and elimination measurements in laboratory experiments with black silver carp (Aristichthys nobilis). The biological half-lives of the three herbicides on exposure at high and low concentrations were 11É6 and 23É1 days for butachlor, 13É9 and 17É3 days for thiobencarb and 5É6 and 4É5 h for chlomethoxyfen, respectively. One-and two-compartment models were used to elucidate the bioconcentration kinetics. Data from a short-term, 14-day expiry experiment were used to estimate the parameters in the models by non-linear regression analysis, and the bioconcentration factors (BCF) in the steady state were calculated from those parameters. The BCF in the steady state have the descending order thiobencarb [ chlomethoxyfen [ butachlor at high concentration, and butachlor [ thiobencarb [ chlomethoxyfen at low concentration. One-compartment model for butachlor and thiobencarb and a two-compartment model for chlomethoxyfen are useful to predict the BCF on prolonged exposure and, further, to assess the inÑuence of these pollutants.

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Toxicokinetics in fish: Accumulation and elimination of six chlorobenzenes by guppies

Cited by 217 publications

References 13 publications

Toxicokinetics and Bioconcentration of Polycyclic Aromatic Hydrocarbons in Freshwater Isopods

Toxicokinetics and Bioconcentration of Polycyclic Aromatic Hydrocarbons in Freshwater Isopods

Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure

Accumulation and Elimination Kinetics of Herbicides Butachlor, Thiobencarb and Chlomethoxyfen byAristichthys nobilis

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