Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure

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doi:10.1787/9789264185296-en

Cited by 87 publications

(32 citation statements)

References 3 publications

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“…The dietary, lipid-corrected BMF (biomagnification factor); dietary assimilation efficiency; and growth-corrected wholebody half-lives were calculated (OECD, 2012). The uptake phase of the dietary bioaccumulation test is described by:…”

Section: Bioaccumulation Endpoint Analysesmentioning

confidence: 99%

“…(2) reflects gill elimination, fecal egestion, biotransformation, and growth dilution. The contribution of growth dilution (using growth rates during the study period) allows the calculation of a growth-corrected half-life for the calculation of the BMF, which can then be expressed on a lipid-normalized basis (OECD, 2012).…”

Section: Bioaccumulation Endpoint Analysesmentioning

confidence: 99%

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Biodegradation and Ecotoxicity of Branched Alcohol Ethoxylates: Application of the Target Lipid Model and Implications for Environmental Classification

Bragin

Davis

Kung

et al. 2019

J Surfact & Detergents

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With the advent of global regulations for safer detergent and an emphasis on a shift toward more environmentally friendly formulations, the environmental profile of surfactant chemistries have moved to the forefront of product formulation and design. The two cornerstones of surfactant environmental profiles are the ability to biodegrade in the natural environment and the ecological hazard profile. The objectives of this article are to describe biodegradation and aquatic toxicity data for a series of branched oxo‐alcohol ethoxylate (AEO) surfactants; to apply the target lipid model (TLM) for deriving model‐based threshold hazard concentrations (HC5) of AEO; and, finally, to accurately determine aquatic classifications for AEO surfactants for use in regulatory classification frameworks. Biodegradation results indicate a high level of biodegradability of branched AEO, with C8–C13‐rich oxo‐alcohols with 1–20 mol of ethoxylate meeting the readily biodegradable criteria. Results from acute and chronic toxicity tests indicated comparable or lesser aquatic toxicity versus linear AEO structures previously reported in the literature. The TLM model, applied a priori, resulted in good agreement with acute toxicity data (RMSE = 0.49) and is comparable to the root mean square errors (RMSE) previously determined for other narcotic chemicals (RMSE = 0.46–0.57). Model errors for invertebrates and fish were smaller than those for algae, with the TLM systematically overpredicting acute and chronic classification of two of seven branched AEO. Furthermore, TLM‐predicted HC5 values were determined to be sufficiently conservative, with 100% of observed chronic data (N = 79) falling above the HC5 threshold values, providing a useful tool for the risk assessment of AEO.

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Section: Bioaccumulation Endpoint Analysesmentioning

confidence: 99%

Section: Bioaccumulation Endpoint Analysesmentioning

confidence: 99%

Biodegradation and Ecotoxicity of Branched Alcohol Ethoxylates: Application of the Target Lipid Model and Implications for Environmental Classification

Bragin

Davis

Kung

et al. 2019

J Surfact & Detergents

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show abstract

“…Although technical HBCDD consists of 70 to 95% of -HBCDD and 5 to 30% of -and -HBCDD, the isomer predominates in wildlife as well as in animal-derived products (Marvin et al, 2011;Koch et al, 2015). This shift is generally ascribed to a rapid degradation of -and -HBCDD compared to -HBCDD, through debromination and hydroxylation (Hakk et al, 2012;Zhang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Accumulation of α-hexabromocyclododecane (α-HBCDD) in tissues of fast- and slow-growing broilers (Gallus domesticus)

Jondreville

Cariou

Méda³

et al. 2017

Chemosphere

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The aim of the current study was to describe the fate of ingested α-hexabromocyclododecane (α-HBCDD) in fast-growing (FG) and slow-growing (SG) broilers, through an exposure to a dietary concentration of 50 ng α-HBCDD g feed during 42 and 84 days, respectively. Depuration parameters were assessed in SG broilers successively exposed during 42 days and depurated during 42 days. At market age, SG broilers had ingested 42% more feed than FG broilers, while their body weight gain per g of feed ingested was 34% lower. No isomerization of α- to β- or γ-HBCDD forms occurred, while OH-HBCDD was identified as a product of α-HBCDD metabolism. Irrespective of the strain, abdominal fat displayed the highest α-HBCDD concentration on a lipid weight basis, followed leg muscles and then breast muscle, liver and plasma. The accumulation ratios of α-HBCDD were slightly higher in SG (6.7, 2.1, 2.6 and 9.9 in leg muscles, breast muscle, liver and abdominal fat, respectively) than in FG broilers (5.2, 2.2, 1.1 and 8.4, respectively). The elimination half-lives in SG broilers were 20, 12 and 19 d in leg muscles, breast muscle and abdominal fat, respectively, to which dilution through growth contributed for around 50%. The overall assimilation efficiency of α-HBCDD was estimated at 58 and 50% in FG and SG broilers, respectively, while 22 and 17% of α-HBCDD ingested were estimated to be eliminated in excreta as metabolites.

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“…In fact, PBPK models are an ethical and scientifically sound method to predict exposure to toxic xenobiotics in humans through animal-to-human extrapolation or based on human biomonitoring data. But (PB)TK models are also of particular interest in ERA, when the calculation of bioaccumulation metrics is required by regulators in support of decision making in evaluating dossiers for substance marketing authorisations [18,17,3].…”

Section: Graphical Abstract 1 Introductionmentioning

confidence: 99%

Generic solving of one-compartment toxicokinetic models

Charles

Ratier

Lopes

2021

Preprint

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This paper gives the full analytical solution of the generic set of ordinary differential equations that define one-compartment toxicokinetic models. These models describe uptake and elimination processes taking place within living organisms when exposed to chemical substances. The models solved in this paper consider living organisms as a unique compartment, into which a parent compound enters via several possible exposure routes and from which it is eliminated as well as its potential metabolites. Benefiting from generic solutions of one-compartment toxicokinetic models is particularly useful when fitting them to experimental data, facilitating the writing of the inference algorithms leading to parameter estimates. Additionally, these models are of crucial interest in environmental risk assessment for the calculation of bioaccumulation metrics as required by regulators in support of decision making when they evaluate dossiers for marketing authorisation of active substances.

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Test No. 305: Bioaccumulation in Fish: Aqueous and Dietary Exposure

Cited by 87 publications

References 3 publications

Biodegradation and Ecotoxicity of Branched Alcohol Ethoxylates: Application of the Target Lipid Model and Implications for Environmental Classification

Biodegradation and Ecotoxicity of Branched Alcohol Ethoxylates: Application of the Target Lipid Model and Implications for Environmental Classification

Accumulation of α-hexabromocyclododecane (α-HBCDD) in tissues of fast- and slow-growing broilers (Gallus domesticus)

Generic solving of one-compartment toxicokinetic models

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