Toxicogenomics of resveratrol in rat liver

Hebbar, Vidya; Shen, Guoxiang; Hu, Rong; Kim, Bok Ryang; Chen, Chi; Korytko, Peter J.; Crowell, James A.; Levine, Barry; Kong, Ah Ng Tony

doi:10.1016/j.lfs.2004.10.039

Cited by 100 publications

(70 citation statements)

References 24 publications

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“…GSSE is safe and devoid of any toxicity even at the high dosage used (Hebbar et al, 2005). GSSE protection could be mediated by ROS scavenging activity as demonstrated for resveratrol (Leonard et al, 2003).…”

Section: Discussionmentioning

confidence: 97%

Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma

Hamlaoui

Mokni

Limam

et al. 2012

Bangladesh J Pharmacol

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In this study, the protective role of grape seed and skin extract (GSSE) against doxorubicin-induced blood toxicity has been evaluated in rats. Rats were treated with the extract for 8 days and injected with doxorubicin (20 mg/kg) at the 4th day. At the end of the treatment, blood samples were collected for oxidative stress parameters determination and anti-oxidant enzymes. Doxorubicin increased erythrocytes and plasma malondialdehyde, free iron, H2O2 and carbonylation, decreased calcium and also decreased erythrocytes catalase, peroxidase and superoxide dismutase (specially the Fe isoform). Doxorubicin also decreased plasma catalase and superoxide dismutase (Cu/ Zn and Fe isoforms) but increased peroxidase. Doxorubicin increased plasma alanine aminotransferase and aspartate aminotransferase but decreased them within erythrocytes. GSSE co-treatment counteracted almost all deleterious effects induced by doxorubicin. In conclusion, doxorubicin induced a prooxidative stress into rat erythrocytes and plasma and GSSE exerted antioxidant properties which can be attributed to free iron and calcium modulation. Article Info

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Section: Discussionmentioning

confidence: 97%

Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma

Hamlaoui

Mokni

Limam

et al. 2012

Bangladesh J Pharmacol

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“…The oral route of administration as well as the dose (100 mg/kg) of resveratrol was selected based on the in vivo evidence of the efficacy of resveratrol in inhibiting hepatic tumorigenesis in rats without any toxic manifestations (Bishayee & Dhir, 2009). Additionally, no adverse effects have been found for a dose up to 300 mg resveratrol/kg/day for 4 weeks in rats as per the studies conducted by other investigators (Crowell et al, 2004;Hebbar et al, 2005). Food and water intake as well as behavioral changes were monitored every day and body weight of animals recorded every week over 28 days.…”

Section: In Vivo Ovarian Cancer Studymentioning

confidence: 91%

Resveratrol Exerts Differential Effects in Vitro and in Vivo against Ovarian Cancer Cells

Stakleff¹,

Sloan²,

Blanco³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Epithelial ovarian cancer represents the most lethal gynecological cancer, and the high mortality rate makes this malignancy a major health concern. Poor prognosis results from an inability to detect ovarian cancers at an early, curable stage, as well as from the lack of an effective therapy. Thus, effective and novel strategies for prevention and treatment with non-toxic agents merit serious consideration. Resveratrol, obtained from grapes, berries, peanuts and red wine, has been shown to have a potent growth-inhibitory effect against various human cancer cells as well as in in vivo preclinical cancer models. The objective here was to evaluate potential antitumor effects of resveratrol in both in vitro and in vivo NuTu-19 ovarian cancer models. In vitro an invasion assay was performed. After 48 h, the numbers of viable cells that invaded the extracellular matrix layer were reduced by 94% with resveratrol in comparison to control. For the in vivo anti-tumor assessment, 10 rats were injected with NuTu-19 cells into the ovarian bursa. Thereafter, half were provided with a diet mixed with a dose of 100 mg resveratrol/kg body weight/day for 28 days. Following sacrifice, anticancer effects were assessed by histological evaluation of ovarian as well as surrounding tissues, and immunohistochemical detection of cell proliferation and apoptosis, but there were no observable differences between the control and resveratrol-treated groups for any of the biological endpoints. While resveratrol is effective in suppressing the in vitro cellular invasion of NuTu-19 ovarian cancer cells, these effects do not appear to impact on in vivo NuTu-19 ovarian cancers in rats.

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“…The experiments of Hebbar et al [27] demonstrated that the toxicity of resveratrol is very low -the compound is nowadays available in the form of tablets and is recommended as a dietary supplement.…”

Section: Introductionmentioning

confidence: 99%

The inhibitory effect of resveratrol on leptin secretion from rat adipocytes

Szkudelska

Nogowski

Szkudelski

2009

Eur J Clin Investigation

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Background Resveratrol was found to alleviate consequences of some metabolic disturbances which may be due to inappropriate dietary habits. It decreases mortality, increases insulin sensitivity and improves motor functions; these effects are accompanied by reduced plasma leptin and insulin. Leptin plays a significant role in the regulation of food intake and energy expenditure -elevated level in blood is one of the reasons of leptinresistance and obesity. In this study, the direct effect of resveratrol on leptin secretion from isolated adipocytes was investigated.

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Toxicogenomics of resveratrol in rat liver

Cited by 100 publications

References 24 publications

Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma

Grape seed and skin extract protects against acute chemotherapy toxicity induced by doxorubicin in rat red blood cells and plasma

Resveratrol Exerts Differential Effects in Vitro and in Vivo against Ovarian Cancer Cells

The inhibitory effect of resveratrol on leptin secretion from rat adipocytes

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