Toxicogenetic evaluation of Smallanthus sonchifolius (yacon) as a herbal medicine

Szokalo, Rocío Ayelén Moreira; Redko, Flavia; Ulloa, Jerónimo Luis; Flor, Sabrina; Tulino, María Soledad; Muschietti, Liliana; Carballo, Marta A.

doi:10.1016/j.jep.2020.112854

Cited by 7 publications

(1 citation statement)

References 18 publications

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“…The root and leaves are being used by people who have diabetes or are suffering from digestive and renal disorders. Studies depicted that S. sonchifolius has antibacterial, anti-in ammatory, antifungal, and antiparasitic properties [22]. There is growing interest in studying other pharmacological properties, such as hypoglycemic properties and e cacy against leukemia and pancreatic cancer cells [23].…”

Section: Introductionmentioning

confidence: 99%

In vitro and In vivo experimental study of Aqueous and Ethanolic Extracts of Selected Medicinal Plants for Free Radical Scavenging and Hypoglycemic Activity

Baral,

Rawal,

Panta

2024

Preprint

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Background Diabetes mellitus (DM) is a condition affecting metabolism characterized by a high level of glucose in the bloodstream, either due to failure of the Islets of Langerhans of the pancreatic beta cell to produce enough insulin (Type I diabetes) or when there is insulin resistance in body cells (Type II diabetes). Oxidative stress caused by the free radicals produced during the oxidation of glucose, protein glycation by non-enzymatic pathway, and the gradual breakdown of glycated protein by oxidation, is a significant factor in the pathogenesis of diabetic complications. This study was designed for the qualitative and quantitative phytoconstituent determination, free radical lowering activity, and in-vitro and in-vivo glucose-lowering effect of selected parts of five medicinal plants of Nepal using two solvents, i.e., methanol and water of different polarity. The selected plant species are Artocarpus heterophyllus Lam., Dendrocalamus hamiltoni, Fagopyrum megacarpumH. Hara., Somallanthus sonchifolius (poepp)H. Rob., Urtica parvifloraRoxb. Results The result from the study revealed that among the tested samples, A. heterophyllus, F. megacarpum, and S. sonchifoliushave higher Total Phenolic Content (TPC) and Total Flavonoid Content (TFC), conclusively showing significant free radical scavenging properties. The in-vitrostudy for the hypoglycemic activity of plant samples showed that ethanolic and water extracts of S. sonchifolius have potent alpha-amylase inhibitory effect showing the half-maximal inhibitory concentration as 0.136 mg/ml and 0.168 mg/ml respectively. In vivo hypoglycemic activity study of S. sonchifolius depicted the blood glucose lowering effect in a dose-dependent manner having a comparative release profile to standard Metformin. S. sonchifolius with the dose of 500 mg/kg showed the optimal decrement in blood glucose level in normal mice by 17.99%, while the same dose of S. sonchifolius diminished the glucose level in blood by 15.74% in glucose-loaded hyperglycemic mice in 120 minutes. Conclusion The results from the study outlined that the positive qualitative and quantitative phytoconstituent determination and the ability to eliminate free radicals align with the in vitro and in vivohypoglycemic activity test.

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Section: Introductionmentioning

confidence: 99%

In vitro and In vivo experimental study of Aqueous and Ethanolic Extracts of Selected Medicinal Plants for Free Radical Scavenging and Hypoglycemic Activity

Baral,

Rawal,

Panta

2024

Preprint

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P08-08 Toxicogenic effects of leaf extracts from an Andean medicinal plant

et al. 2022

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Chemical profile and toxicogenetic safety assessment of Smallanthus sonchifolius (yacon) organic extracts

Szokalo

Ulloa

Tulino

et al. 2022

Natural Product Research

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The interest in Smallanthus sonchifolius (yacon) has strongly resurfaced due to its multiple beneficial effects on human health. This study aimed at determining the toxicity and the chemical profile of an ethanol extract (EE) and a crude lactone mixture (CLM) of yacon leaves. Cytotoxicity and genotoxicity tests were performed by the MTT assay and the alkaline version of the comet assay respectively. The phytochemical analysis, performed by chromatographic and spectroscopy techniques, revealed the presence of nine sesquiterpene lactones (STLs) and two acyclic diterpene acids. In all cases, cell viability was inversely proportional to the extract concentration employed. The effects obtained with the highest dose of EE were significantly different from those obtained with the negative and solvent controls. Conversely, no significant differences were observed between the lowest doses of EE and controls. As for CLM, all tested doses showed statistically significant increases, as compared to negative and solvent controls.

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Toxicogenetic evaluation of Smallanthus sonchifolius (yacon) as a herbal medicine

Cited by 7 publications

References 18 publications

In vitro and In vivo experimental study of Aqueous and Ethanolic Extracts of Selected Medicinal Plants for Free Radical Scavenging and Hypoglycemic Activity

In vitro and In vivo experimental study of Aqueous and Ethanolic Extracts of Selected Medicinal Plants for Free Radical Scavenging and Hypoglycemic Activity

P08-08 Toxicogenic effects of leaf extracts from an Andean medicinal plant

Chemical profile and toxicogenetic safety assessment of Smallanthus sonchifolius (yacon) organic extracts

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