Toxicity to alveolar macrophages in rats following parenteral injection of nickel chloride

Sunderman, F. William; Hopfer, Sidney M.; Lin, Shan-Meei; Plowman, Marilyn C.; Stojanović, Tomislav; Wong, Steven H.; Zaharia, O; Ziebka, L

doi:10.1016/0041-008x(89)90095-1

Cited by 51 publications

(17 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, both parenteral and inhalation exposure of soluble NiCl 2 causes activation of alveolar Mø followed within 2 days by suppressed phagocytic activity and enhanced lipid peroxidation (31). Similar findings have also been observed in rabbits exposed by inhalation of Ni dust for 1-6 months (32).…”

Section: Discussionsupporting

confidence: 70%

A role for associated transition metals in the immunotoxicity of inhaled ambient particulate matter.

Zelikoff

Schermerhorn

Fang

et al. 2002

Environ Health Perspect

View full text Add to dashboard Cite

Epidemiologic studies demonstrate that infection, specifically pneumonia, contributes substantially to the increased morbidity and mortality among elderly individuals following exposure to ambient particulate matter (PM). This laboratory has previously demonstrated that a single inhalation exposure of Streptococcus pneumoniae-infected rats to concentrated ambient PM 2.5 (particulate matter with aerodynamic diameter ≤ 2.5 µm) from New York City (NYC) air exacerbates the infection process and alters pulmonary and systemic immunity. Although these results provide some basis for explaining the epidemiologic findings, the identity of specific PM constituents that might have been responsible for the worsening pneumonia in exposed hosts remains unclear. Thus, studies were performed to correlate the physicochemical attributes of ambient PM 2.5 with its in vivo immunotoxicity to identify and characterize the role of constitutive transition metals in exacerbating an ongoing streptococcal infection. Uninfected or previously infected rats were exposed in the laboratory to soluble divalent Fe, Mn, or Ni chloride salts. After exposure, uninfected rats were sacrificed and their lungs were lavaged. Lungs from infected hosts were used to evaluate changes in bacterial clearance and effects of exposure on the extent/severity of infection. Results demonstrated that inhalation of Fe altered innate and adaptive immunity in uninfected hosts, and both Fe and Ni reduced pulmonary bacterial clearance in previously infected rats. The effects on clearance produced in infected Fe-exposed rats were similar to those seen in infected rats exposed to ambient NYC PM. Taken together, these studies demonstrate that inhaled ambient PM can worsen the outcome of an ongoing pulmonary infection and that associated Fe may play some role in the immunotoxicity.

show abstract

Section: Discussionsupporting

confidence: 70%

A role for associated transition metals in the immunotoxicity of inhaled ambient particulate matter.

Zelikoff

Schermerhorn

Fang

et al. 2002

Environ Health Perspect

View full text Add to dashboard Cite

show abstract

“…This ''dual'' role is complex but not unprecedented as noted by others who have tested the effects of metal ions on cells. 33,40 In vivo, where a concentration gradient of a released metal ion is likely around an implant, these results suggest that multiple and complex mechanisms may be acting on ICAM-1 expression depending on the locus relative to the implant. Clearly, further study is necessary to define mechanisms by which Ni ions act and the effects on other CAMs and cytokine levels which are involved in the recruitment of inflammatory cells to the implant site.…”

Section: Discussionmentioning

confidence: 92%

Effect of Ni ions on expression of intercellular adhesion molecule 1 by endothelial cells

Wataha

Sun

Hanks

et al. 1997

J. Biomed. Mater. Res.

View full text Add to dashboard Cite

Previous studies have shown that Ni-based alloys implanted into soft tissues cause an infiltration of inflammatory cells around the implant. This phenomenon is potentially important to dental alloys which are adjacent to oral tissues. To help define the mechanisms by which Ni causes an infiltration of inflammatory cells, we exposed endothelial cells in vitro to Ni ions and measured the expression of intercellular adhesion molecule 1 (ICAM-1). ICAM-1 is known to be involved in the recruitment of inflammatory cells from the bloodstream. We also exposed macrophages to Ni ions to test the hypothesis that Ni might alter cytokine secretion and subsequently cause expression of ICAM-1 on endothelial cells. The results showed that Ni ions could promote the expression of ICAM-1 on endothelial cells, but only at concentrations which were high enough (850 mumol/L for 24 h) to suppress cell metabolic activity. Although we had previous evidence that Ni could cause macrophages to secrete cytokines such as interleukin 1 beta, Ni-exposed macrophage supernatants did not induce expression of ICAM-1 on endothelial cells at concentrations subtoxic to the macrophages (85 mumol/L). At subtoxic concentrations, Ni ions were able to suppress ICAM-1 expression on endothelial cells which were stimulated with lipopolysaccharide. Thus, Ni ions either promoted or suppressed the expression of ICAM-1 depending on their concentration. This dual action of Ni ions may be important in vivo where a gradient of concentrations of released ions is likely to exist around the implanted biomaterial. Further studies are necessary to determine the effect of time of exposure and the molecular mechanisms of increased ICAM-1 expression.

show abstract

“…Plasma insulin was determined by using a rat insulin radioimmunoassay kit (Linco Research Inc., St. Charles, USA) in a gamma counter (Peckard, USA) based on the method of Ram et al [20]. Lipid peroxidation was determined by quantifying MDA concentrations using the method described by Uchiyama and Mihara [21] and modified by Sunderman et al [22]. The plasma total cholesterol (TC), HDL-cholesterol (HDLC) and triglyceride concentrations were determined using an enzymatic method (Sigma Diagnostics, St Louis, MO).…”

Section: Methodsmentioning

confidence: 99%

Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats

Li¹

2007

International Journal of Biological Macromolecules

198

112

View full text Add to dashboard Cite

Toxicity to alveolar macrophages in rats following parenteral injection of nickel chloride

Cited by 51 publications

References 38 publications

A role for associated transition metals in the immunotoxicity of inhaled ambient particulate matter.

A role for associated transition metals in the immunotoxicity of inhaled ambient particulate matter.

Effect of Ni ions on expression of intercellular adhesion molecule 1 by endothelial cells

Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats

Contact Info

Product

Resources

About