Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats

Li, X.-M.

doi:10.1016/j.ijbiomac.2006.11.002

Cited by 198 publications

(118 citation statements)

References 32 publications

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“…Although the hypoglycemic effect of LBP-X surpassed the other extracts, yet the latter exhibited stronger antioxidant activity because crude extracts were identified to be rich in antioxidants (e.g., carotenoids, riboflavin, ascorbic acid, thiamine, nicotinic acid). In Li [210] has isolated Lycium barbarum polysaccharides (LBP), which are identified as one of the active ingredients of the fruits, and tested its capacity to stand the oxidative insult using a STZ-induced hyperglycemic model. The author found again that the LBP reinstated the STZ-induced abnormal oxidative indices, results that are in line with another study by Wu et al [211] , who also studied the antidiabetic effects of these polysaccharides, using rats with NIDDM.…”

Section: Antioxidantsmentioning

confidence: 99%

Phytotherapy in diabetes: Review on potential mechanistic perspectives

El‐Abhar

Schaalan

2014

WJD

108

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Diabetes mellitus (DM) is a widely spread epidemic disease that results from the absence of insulin, decreased secretion and/or impaired function. Since DM is a multifactorial disease, the available pharmaceuticals, despite their sensible treatment, target mostly one pathway to control hyperglycemia and encounter several side effects. Therefore, new therapeutic paradigms aim to hit several pathways using only one agent. Traditionally, antidiabetic plants and/or their active constituents may fulfill this need. More than 200 species of plants possess antidiabetic properties which were evaluated mostly by screening tests without digging far for the exact mode of action. Searching among the different literature resources and various database and in view of the above aspects, the present article provides a comprehensive review on the available antidiabetic plants that have been approved by pharmacological and clinical evaluations, and which their mechanism(s) of action is assured. These plants are categorized according to their proved mode of action and are classified into those that act by inhibiting glucose absorption from intestine, increasing insulin secretion from the pancreas, inhibiting glucose production from hepatocytes, or enhancing glucose uptake by adipose and muscle tissues. The current review also highlights those that mimic in their action the new peptide analogs, such as exenatide, liraglutide and dipeptidylpeptidase-4 inhibitors that increase glucagon-like peptide-1 serum concentration and slow down the gastric emptying.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypoglycaemic nutraceuticals; Antidiabetic phyto-constituents; Medicinal plants; Phytotherapy; Diabetes mellitus Core tip: Diabetes is a serious metabolic disorder that is currently treated by different types of synthetic oral hypoglycemic agents, in addition to insulin. However, due to the unwanted side effects, the efficacies of these compounds are debatable and there is a demand for new compounds for the treatment of diabetes. Therefore, attention has been directed towards nutraceuticals originating from plants that are rich in antidiabetic phyto-constituents. Although the evidenced-based therapeutic usage of many plants is scarce, the plants cited in this review are those reputed traditionally for their antidiabetic effect and that were verified either experimentally or clinically.El-Abhar HS, Schaalan MF. Phytotherapy in diabetes: Review on potential mechanistic perspectives. World J Diabetes 2014; 5(2): 176-197 Available from:

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Section: Antioxidantsmentioning

confidence: 99%

Phytotherapy in diabetes: Review on potential mechanistic perspectives

El‐Abhar

Schaalan

2014

WJD

108

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“…It is a group of metabolic disorders with different underlying etiologies, each characterized by hyperglycemia due to under utilization and/or overproduction of glucose. Hyperglycemia is a key clinical manifestation of diabetes mellitus (Li, 2007).…”

Section: Introductionmentioning

confidence: 99%

Hypoglycemic effect of crude exopolysaccharides produced byCerrena unicolor,Coprinus comatus, andLenzites betulinaisolates in streptozotocin- induced diabetic rats

Yamaç

Zeytinoğlu

Kanbak

et al. 2009

Pharmaceutical Biology

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“…The ␤-glycan structural aspect may contribute to their biologic function (5). Previous studies have shown that LBP can enhance the immune function (1,2,6), antagonize aging and oxidation (7)(8)(9)(10), protect liver damage (11), lower blood glucose level (12), reduce the side effects of chemotherapy and radiotherapy (13,14), and act against cancer (2,15,16). We speculate that the immunostimulatory activity of LBP is through activating dendritic cells (DCs).…”

mentioning

confidence: 99%

Polysaccharide-Protein Complex from Lycium barbarum L. Is a Novel Stimulus of Dendritic Cell Immunogenicity

Chen

Lu²,

Srinivasan

et al. 2009

The Journal of Immunology

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Dendritic cell (DC) immunogenicity correlates with its maturation, which can be induced by toxic microbial products such as LPS. In this study, we report that a nontoxic polysaccharide-protein complex isolated from a Chinese medicinal herb, Lycium barbarum (LBP), induces phenotypic and functional maturation of DCs with strong immunogenicity. LBP up-regulated DC expression of CD40, CD80, CD86, and MHC class II molecules; down-regulated DC uptake of Ag; enhanced DC allostimulatory activity; and induced IL-12p40 and p70 production. All of its five fractions were active. LBP developed enhanced Th1 response, and LBP-treated DCs enhanced Th1 and Th2 responses in vitro and in vivo. Our study provides evidence and rationale on using LBP in various clinical conditions to enhance host immunity and suggests LBP as a potent adjuvant for the design of DC-based vaccines.

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Protective effect of Lycium barbarum polysaccharides on streptozotocin-induced oxidative stress in rats

Cited by 198 publications

References 32 publications

Phytotherapy in diabetes: Review on potential mechanistic perspectives

Phytotherapy in diabetes: Review on potential mechanistic perspectives

Hypoglycemic effect of crude exopolysaccharides produced byCerrena unicolor,Coprinus comatus, andLenzites betulinaisolates in streptozotocin- induced diabetic rats

Polysaccharide-Protein Complex from Lycium barbarum L. Is a Novel Stimulus of Dendritic Cell Immunogenicity

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