Toxicity studies of the rhizome Curcuma xanthorrhiza Roxb. and Curcuma zedoaria Roscoe on hematological and male reproduction system of mice (Mus musculus L.)

Listyawati, Shanti

doi:10.13057/biofar/f040103

Cited by 4 publications

(9 citation statements)

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“…C. zedoaria secara empiris digunakan untu mengatasi diare di Banyumas (Suparman dkk., 2012) Konstituen fitokimia rimpang C. zedoaria mengandung tanin, flavonoid, saponin, alkaloid, dan steroid (Azam et al, 2014) Ekstrak etanol dari C. zedoaria memiliki anti-efek diare dengan menghambat minyak jarak yang menginduksi diare pada mencit dengan mekanisme anti sekresi. Mekanisme ini menghambat stimulasi sekresi yang melepaskan prostaglandin (Azam et al, 2017) Studi toksisitas kronis ekstrak etanol rimpang C. zedoaria tidak memiliki efek yang signifikan terhadap perubahan hematologi dan spermatogenik (Listyawati, 2006) Curcuma zanthorrhiza Roxb.…”

Section: Curcuma Longa Lunclassified

“…Kandungan fitokimia temulawak adalah alkaloid, flavonoid, fenolik, saponin, triterpennoid, dan glikosida. Zat aktif yang berperan sebagai antibakteri adalah kurkumin dan minyak atsiri (Dicky & Apriliana, 2016) Ekstrak etanol C. zanthorrhiza memiliki daya hambat terhadap bakteri Staphylococcus aureus dan Escherichia coli pada semua konsentrasi uji (Dicky & Apriliana, 2016) Studi toksisitas kronis ekstrak etanol rimpang C. zanthorrhiza Roxb tidak memiliki efek yang signifikan terhadap perubahan hematologi dan spermatogenik (Listyawati, 2006) Allium cepa L.…”

Section: Curcuma Longa Lunclassified

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Studi Etnofarmakologi Tumbuhan Obat Yang Digunakan Oleh Penyehat Tradisional Untuk Mengatasi Diare Di Sulawesi Selatan

Mustofa¹,

Rahmawati²

2019

j. tumbuh. obat indonesia

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ABSTRACT Medicinal plants for health effort and diseases treatment has been used by ethnic groups in South Sulawesi for years. One of them is for diarrhea treatment. South Sulawesi is one of the top five provinces with the highest incidence and period prevalence of diarrhea in Indonesia. The purpose of this study was to investigate the species of medicinal plants used by traditional healer in South Sulawesi for anti-diarrhea and their scientific evidence. The data was obtained from the exploration of local ethnomedicin knowledge and medicinal plant based on community in Indonesia in 2012-2015 and 2017. The data was analyzed to find out the fidelity level, used value (UV), choice value (CV), and factor of informant’s consensus (FIc). The result reported information about thirty medicinal plants used for diarrhea treatment, including the plants name, part used, and preparation method that obtained from 48 traditional healer of 19 ethnic groups in South Sulawesi. The fidelity level were 41,67% for Psidium guajava, 8,33% for Mangifera sp, 6,25% for Curcuma domestica and C. Zedoaria, 4,17% for Allium cepa, Anacardium officinale, Syzigium cumini, and C.xanthorrhiza. The highest UV and CV were 0,42 and 13,84 for Psidium guajava. The informant’s consensus of medicinal plant for diarrhea treatment was 0,38. The commonly used parts was the leaves and most of the used methods were administered orally. The conclusions of this study were ethnic groups in South Sulawesi has various formula of medicinal plants for diarrhea treatment, but P.guajava was the most commonly used. Those formulas information for diarrhea treatment would be an alternative to overcome diarrhea problems in South Sulawesi. Key words: medicinal plant, traditional healer, diarrhea, ABSTRAK Pengetahuan lokal dalam pemanfaatan tumbuhan obat untuk mencegah dan mengatasi penyakit telah dimiliki secara turun temurun oleh etnis-etnis di Sulawesi Selatan. Salah satunya adalah untuk mengatasi diare. Sulawesi Selatan termasuk dalam lima provinsi dengan insiden maupun period prevalence diare tertinggi di Indonesia. Tujuan dari penelitian ini adalah untuk mengungkap jenis-jenis tumbuhan obat yang digunakan hatttra di Sulawesi Selatan dalam ramuan anti diare dan bukti ilmiah penggunaan tanaman obat tersebut untuk mengatasi diare. Studi ini menggunakan data sekunder yang diperoleh dari Eksplorasi pengetahuan lokal etnomedisin dan tumbuhan obat berbasis komunitas di Indonesia pada tahun 2012,2015 dan 2017. Analisis data dilakukan untuk mengetahui Fidelity level, Used value, Choice value, Factor of informant’s consensus dan studi referensi ilmiahnya. Hasil studi menunjukkan informasi tentang tiga puluh tanaman obat untuk mengatasi diare yang diperoleh dari 48 penyehat tradisional yang berasal dari 19 etnis di Sulawesi Selatan. Informasi tersebut termasuk nama tanaman, bagian yang digunakan, dan metode persiapan. Fidelity level yang tertinggi adalah 41,67% untuk Psidium guajava, disusul 8,33% untuk Mangifera sp, 6,25% untuk Curcuma domestica dan C. Zedoaria, 4,17% untuk Allium cepa, Anacardium officinale, Syzigium cumini, dan C. xanthorrhiza. Nilai UV dan CV tertinggi adalah 0,42 dan 13,84 untuk P. guajava. Konsensus informan tentang tanaman obat untuk pengobatan diare adalah 0,38. Bagian yang umum digunakan adalah daun dan sebagian besar cara pemakaian dengan diminum. Dari hasil tersebut dapat disimpulkan bahwa kelompok etnis di Sulawesi Selatan memiliki berbagai formula tanaman obat untuk mengatasi diare, tetapi P.guajava adalah yang paling banyak digunakan. Informasi formula untuk mengatasi diare diharapkan dapat menjadi alternatif untuk masalah diare di Sulawesi Selatan. Kata kunci: tumbuhan obat, penyehat tradisional, diare

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Section: Curcuma Longa Lunclassified

Studi Etnofarmakologi Tumbuhan Obat Yang Digunakan Oleh Penyehat Tradisional Untuk Mengatasi Diare Di Sulawesi Selatan

Mustofa¹,

Rahmawati²

2019

j. tumbuh. obat indonesia

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“…The LD 50 was 500 mg/kg bw (Lakshmi et al, 2011). Furthermore, C. zedoaria ethanol extract at 150 mg/kg/day revealed a significant reduction of RBC, Hb level, and spermatozoa quality in chronic toxicity evaluation (Listyawati, 2006). The essential oil of C. zedoaria at 100 or 200 mg/kg revealed weight loss, and abnormal hematological and biochemical changes on dams and embryos in GD17 pregnant rats.…”

Section: Toxicological Studiesmentioning

confidence: 93%

“…During 14 days of observation, rats showed no clinical toxic signs, such as hypoactivity, hyperactivity, lethargy, dermatitis, anorexia, depression, and jaundice as well as no abnormalities in the kidney and liver (Rahim et al, 2014). Listyawati (2006) reported the chronic toxicity study of ethanol extract of C. zanthorrhiza. The extract at 50 mg/kg/day did not induce significant effects on spermatogenic and hematological changes (Listyawati, 2006).…”

Section: Toxicological Studiesmentioning

confidence: 99%

“…Listyawati (2006) reported the chronic toxicity study of ethanol extract of C. zanthorrhiza. The extract at 50 mg/kg/day did not induce significant effects on spermatogenic and hematological changes (Listyawati, 2006). C. zanthorrhiza supplement at 2000 mg/kg showed no significant abnormalities on the lung, heart, liver, kidney, and stomach.…”

Section: Toxicological Studiesmentioning

confidence: 99%

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Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review

et al. 2021

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Curcuma species (family: Zingiberaceae) are widely utilized in traditional medicine to treat diverse immune-related disorders. There have been many scientific studies on their immunomodulating effects to support their ethnopharmacological uses. In this review, the efficacy of six Curcuma species, namely, C. longa L., C. zanthorrhiza Roxb., C. mangga Valeton & Zijp, C. aeruginosa Roxb. C. zedoaria (Christm.) Roscoe, and C. amada Roxb., and their bioactive metabolites to modulate the immune system, their mechanistic effects, and their potential to be developed into effective and safe immunomodulatory agents are highlighted. Literature search has been carried out extensively to gather significant findings on immunomodulating activities of these plants. The immunomodulatory effects of Curcuma species were critically analyzed, and future research strategies and appropriate perspectives on the plants as source of new immunomodulators were discussed. Most of the pharmacological investigations to evaluate their immunomodulatory effects were in vivo and in vitro experiments on the crude extracts of the plants. The extracts were not chemically characterized or standardized. Of all the Curcuma species investigated, the immunomodulatory effects of C. longa were the most studied. Most of the bioactive metabolites responsible for the immunomodulating activities were not determined, and mechanistic studies to understand the underlying mechanisms were scanty. There are limited clinical studies to confirm their efficacy in human. Of all the bioactive metabolites, only curcumin is undergoing extensive clinical trials based on its anti-inflammatory properties and main use as an adjuvant for the treatment of cancer. More in-depth studies to understand the underlying mechanisms using experimental in vivo animal models of immune-related disorders and elaborate bioavailability, preclinical pharmacokinetics, and toxicity studies are required before clinical trials can be pursued for development into immunomodulatory agents.

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Javanese Turmeric (Curcuma xanthorrhiza Roxb.): Ethnobotany, Phytochemistry, Biotechnology, and Pharmacological Activities

Rahmat

Lee

Kang

2021

Evidence-Based Complementary and Alternative Medicine

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Curcuma xanthorrhiza Roxb., locally famed as Temulawak, has been extensively utilized in Indonesia as medicinal and nutritional plants since immemorial time. The rhizome of this plant is an important ingredient for jamu formulation (Indonesian traditional medicine). C. xanthorrhiza is traditionally used to treat several ailments such as lack of appetite, stomach disorder, liver illness, constipation, bloody diarrhea, dysentery, arthritis, children’s fevers, hypotriglyceridaemia, hemorrhoids, vaginal discharge, rheumatism, and skin eruptions. To date, over 40 active compounds, including terpenoids, curcuminoids, and other phenolic compounds, have been isolated and identified from C. xanthorrhiza Roxb. Some pharmacological tests reported that C. xanthorrhiza Roxb. has antioxidant, antimicrobial, anti-inflammatory, anticancer and antitumor, antidiabetic, and skincare and hepatoprotective properties. Efforts for biotechnologically production of C. xanthorrhiza have also been conducted, resulting in some micropropagation protocols of this plant. The current review focuses on the botanical description and distribution, ethnomedicinal uses, production and conservation status, phytochemical properties, and pharmacological activities of C. xanthorrhiza Roxb. to provide accurate and reliable data for future researches and commercialization purposes.

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Toxicity studies of the rhizome Curcuma xanthorrhiza Roxb. and Curcuma zedoaria Roscoe on hematological and male reproduction system of mice (Mus musculus L.)

Cited by 4 publications

References 1 publication

Studi Etnofarmakologi Tumbuhan Obat Yang Digunakan Oleh Penyehat Tradisional Untuk Mengatasi Diare Di Sulawesi Selatan

Studi Etnofarmakologi Tumbuhan Obat Yang Digunakan Oleh Penyehat Tradisional Untuk Mengatasi Diare Di Sulawesi Selatan

Immunomodulatory Effects and Mechanisms of Curcuma Species and Their Bioactive Compounds: A Review

Javanese Turmeric (Curcuma xanthorrhiza Roxb.): Ethnobotany, Phytochemistry, Biotechnology, and Pharmacological Activities

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