Toxicity studies of medicinal plants used in sub-Saharan Africa

Mounanga, Marlaine Boukandou; Mewono, Ludovic; Angone, Sophie Aboughe

doi:10.1016/j.jep.2015.06.005

Cited by 55 publications

(20 citation statements)

References 43 publications

(30 reference statements)

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“…A single change in any one system may result in numerous effects in other systems and thus clinical signs of disease are often quite similar for different diseases (Figure 1). Plants are reported to content diverse secondary metabolites that can be toxic to body systems when took without cautious (1,5). Several studies have reported the contribution of certain medicinal plants in the development of various observable side effects after administration.…”

Section: Indicative Clinical Signs Of Toxicitymentioning

confidence: 99%

“…In all parts of the world and more precisely in Africa and other least developed countries from Asia, plants are used in traditional medicine to treat different communicable and non-communicable diseases (1)(2)(3). It is estimated that more that 80% of people living in developing countries frequently use traditional practices for their primary health care needs (1,4). This situation has given rise to inquietude among health professionals and consumers on the issue of safety.…”

Section: Introductionmentioning

confidence: 99%

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Toxicity studies of Acacia nilotica (L.): A review of the published scientific literature

Manzo

Moussa

Ikhiri

et al. 2019

J Herbmed Pharmacol

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Introduction: Acacia nilotica is a valuable plant with medicinal properties that increasinglyincites the curiosity of many researchers. Its pharmacological properties are reported in manystudies, but the fact remains that the plant can be just as toxic as any modern pharmaceuticaldrug. It is very important to dispose sufficient knowledge on what are reported concerning itstoxicity profile. This review is aimed to provide comprehensive summary (all-in-one) of whathave been reported about the toxicity of A. nilotica and to determine the necessity or not toconduct more toxicological studies in a further step toward rationalizing its medicinal use.Methods: Scientific information about the toxicity and or safety of A. nilotica reported elsewherewere reviewed. Search engines such as Google, Bing and Baidu and databases of scientificjournals such as PubMed, Scopus, CAS, CABI, HINARI and AJOL were used to retrieve studiesfrom 1999 to 2017.Results: Few studies have reported the toxicity potential of A. nilotica and most with very limitedinformation. Three of them have reported serious deleterious toxic effects of certain parts of theplant on major organ systems such as kidney and liver. Stem bark as part of A. nilotica appearedto be the most cited to cause observable clinical signs of toxicity and organs lesions.Conclusion: Overall, this review provided comprehensive information on what is known aboutthe toxicity of A. nilotica and showed the necessity to conduct more advanced long-term-basedtoxicological studies.

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Section: Indicative Clinical Signs Of Toxicitymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toxicity studies of Acacia nilotica (L.): A review of the published scientific literature

Manzo

Moussa

Ikhiri

et al. 2019

J Herbmed Pharmacol

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“…fermentation product, resulting in heme accumulation and death of the parasite. 89.62 2500 0.00 5000 0.00 7500 0.00 10,000 0.00 Herbs are used as medicines in developing countries based on the presence of secondary metabolites [29]. Bacteria such as Streptomyces spp.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Potency and Toxicity of Streptomyces Sp. Fermentation Product as an Antimalarial Therapy Against Plasmodium Falciparum

Setyaningsih

Latif²,

Astuty³

et al. 2019

Int J App Pharm

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Objective: This research aims to study the activity of a Streptomyces sp. fermentation product as an antimalarial modality in HepG2 cells.Methods: The effects of the product against Plasmodium falciparum 3D7 were examined using an in vitro technique parasite. The potency of theStreptomyces sp. fermentation product was examined by determining the half maximal inhibitory concentration (IC50), and the mechanism wasstudied using transmission electron microscopy (TEM). Toxicity tests were also conducted.Results: The Streptomyces sp. fermentation product had an IC50 of 0.001 μg/ml against the parasite, versus values of 0.054 and 0.022 μg/ml forquinidine and prodigiosin, respectively. TEM revealed no formation of hemozoin. The Streptomyces sp. fermentation product was non-toxic in HepG2cells based on its cytotoxicity concentration 50% of 1.380 μg/ml.Conclusion: The Streptomyces sp. fermentation product has potential as a potent and non-toxic antimalarial therapy.

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“…However, some herbal remedies or herbal formulae can produce a wide range of adverse reactions, even death [ 21 – 24 ]. Therefore, in recent years scientific investigation of CAM has been focused mainly on safety and toxicological evaluations [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Acute and chronic toxicity of a polyherbal preparation – Jueyin granules

Chen

Guo

Deng

et al. 2018

BMC Complement Altern Med

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BackgroundThe potential toxicity of Chinese herbal medicine has attracted more attention in recent years. Jueyin granules (JYG), a polyherbal formula, have been proven to be an effective agent for treating psoriasis in both animal models and clinical research. However, little is known about the possible acute and chronic toxicity of JYG. The objective of this study was to investigate the safety of JYG in ICR mice and Wistar rats.MethodsTo examine the acute toxicity of JYG, ICR mice were randomly divided into an experimental group and a control group, each comprising 20 mice (10 male and 10 female). The experimental group was fed JYG solution at a dose of 21.5 g/kg, equivalent to 143 times the clinical human dosage, for 14 days, whereas control animals were fed distilled water. In the chronic toxicity test, Wistar rats were divided into four groups, each comprising 40 rats (20 male and 20 female). For 6 months, the experimental animals were given JYG at a dose of 7.5, 3.75 and 1.875 g/kg, whereas control animals were given distilled water. The animals’ body weight, food and water consumptions were monitored weekly. In addition, their biochemical and hematological parameters, histopathology, and body and organ weights were all measured at specific observation time points.ResultsAccording to the results of the acute toxicity test, no mortality was found and no abnormal pathological changes in major organs were observed in mice treated with JYG. In the chronic toxicity test, JYG did not cause significant abnormalities in the physiological parameters or pathological changes in the major organs of the rats.ConclusionThe results indicated that JYG at the given doses did not induce any harmful effects in animals. Thus, it is reasonable to conclude that JYG is safe at the studied dosage levels and causes no acute or chronic toxicity in animal models.Electronic supplementary materialThe online version of this article (10.1186/s12906-018-2211-z) contains supplementary material, which is available to authorized users.

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Toxicity studies of medicinal plants used in sub-Saharan Africa

Cited by 55 publications

References 43 publications

Toxicity studies of Acacia nilotica (L.): A review of the published scientific literature

Toxicity studies of Acacia nilotica (L.): A review of the published scientific literature

In Vitro Potency and Toxicity of Streptomyces Sp. Fermentation Product as an Antimalarial Therapy Against Plasmodium Falciparum

Acute and chronic toxicity of a polyherbal preparation – Jueyin granules

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