Toxicity profiling of Burgmansia aurea Lagerh. Leaves using acute and sub-acute toxicity studies in rats

Saleem, Sana; Anwar, Fareeha; Khan, Aslam; Saleem, Uzma; Akhtar, Muhammad Furqan; Shahzadi, Irum; Ismail, Tariq

doi:10.1016/j.jep.2023.116447

Cited by 7 publications

(2 citation statements)

References 36 publications

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“…Preclinical studies in developing new drugs must include toxicity assessments in suitable animal models. Due to people's unwavering belief in the efficacy of the herb and extensive traditional/folk usage of plants, toxicological testing of natural phytoconstituents, medicinal plants, or any new medicine for their harmful potential becomes essential 72 . The acute oral toxicity study found that large dosages of W. fruticosa leaf and bark extracts up to 5000 mg/kg did not cause toxicity symptoms, and no mice succumbed during the 14‐day observation period.…”

Section: Discussionmentioning

confidence: 99%

“…Due to people's unwavering belief in the efficacy of the herb and extensive traditional/folk usage of plants, toxicological testing of natural phytoconstituents, medicinal plants, or any new medicine for their harmful potential becomes essential. 72 The acute oral toxicity study found that large dosages of W. fruticosa leaf and bark extracts up to 5000 mg/kg did not cause toxicity symptoms, and no mice succumbed during the 14‐day observation period. Extracts having LD 50 values larger than 5000 mg/kg are normally regarded as nontoxic according to the globally harmonized system (GHS) of Classification and Labeling of Chemicals.…”

Section: Discussionmentioning

confidence: 99%

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Exploring therapeutic potential of Woodfordia fruticosa (L.) Kurz leaf and bark focusing on antioxidant, antithrombotic, antimicrobial, anti‐inflammatory, analgesic, and antidiarrheal properties

Rahman,

Soma,

Sultana

et al. 2023

Health Science Reports

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Background and AimsThe study aimed to evaluate the pharmacological properties of methanolic extracts of leaves and barks of Woodfordia fruticosa (L.) Kurz (family: Lythraceae) focusing on antioxidant, thrombolytic, anti‐inflammatory, antibacterial, analgesic, and antidiarrheal effects.Methods1,1‐Diphenyl‐2‐picrylhydrazyl (DPPH) free radical scavenging assay, clot lysis, disc diffusion, and membrane stabilizing methods were employed to assess in vitro antioxidant, thrombolytic, antibacterial, and anti‐inflammatory properties of the leaf and bark methanolic extracts (ME) of W. fruticosa and different organic solvents, that is, petroleum ether (PE), dichloromethane (DCM), chloroform (CL), and aqueous (AQ) fractions. In addition, in vivo central and peripheral analgesic and antidiarrheal activities of both crude extracts were evaluated at two doses (200 and 400 mg/kg of body weight [bw]).ResultsAll the extracts and fractions showed promising antioxidant properties by scavenging DDPH free radicals with IC50 of 6.11–20.79 μg/mL. AQ fraction (41.24%) of leaves and ME (44.90%) of bark exerted notable in vitro thrombolytic activity. The CL fraction of leaves and AQ fraction of the bark showed 43.16% and 45.37% inhibition of RBC hemolysis, respectively, compared to the inhibition of RBC hemolysis by aspirin in a hypotonic‐induced membrane stabilizing assay. Besides, both extracts were observed to provide significant (p < 0.001) central and peripheral analgesic responses at both doses of 200 and 400 mg/kg bw. Furthermore, both doses of bark extract (p < 0.001) and the 400 mg/kg bw of leaf extract (p < 0.05) were observed to possess statistically significant antidiarrheal activity. Additionally, in an in vivo acute toxicity investigation, both extracts had a median lethal dose (LD50) greater than 5000 mg/kg bw, indicating their safety level.ConclusionThe current study proves the ethnomedicinal uses of W. fruticosa; however, further studies are required for phytochemical screening to isolate the responsible bioactive compounds and discover the lead molecules from the plant species.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Exploring therapeutic potential of Woodfordia fruticosa (L.) Kurz leaf and bark focusing on antioxidant, antithrombotic, antimicrobial, anti‐inflammatory, analgesic, and antidiarrheal properties

Rahman,

Soma,

Sultana

et al. 2023

Health Science Reports

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Chemical Characterization, Evaluation of Acute Oral Toxicity, and Anti‐Diabetic Activity of Aloe sabaea Flowers Extract on Alloxan‐Induced Diabetic Rats

Raweh,

El‐Shaibany,

Al‐Mahbashi

et al. 2024

Chemistry & Biodiversity

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The study aimed to conduct chemical profiling, acute in‐vivo toxicity evaluation, and the potential anti‐diabetic effect of standardized Aloe sabaea flowers ethanolic extracts (ASFEE) on alloxan‐induced diabetic rats. The chemical composition was analyzed using GC–MS and TLC techniques. The oral acute toxicity study was performed according to the WHO 2000 and the OECD 420 guidelines. Furthermore, anti‐diabetic activity was investigated using two doses of ASFEE (0.2 and 0.5 g/kg/day BW, p.o.) compared with glibenclamide (5 mg/kg/day, p.o.). A molecular docking investigation of the identified components with the PTPN9 enzyme was performed to figure out the proposed anti‐diabetic mechanism. GC–MS analysis displayed the existence of 18 compounds; most of the compounds were fatty acids and their esters, and phytosterols. Total phenolic and flavonoid contents were 42.00±1.26 mg GAE/g DW and 22.21±1.55 mg QE/g DW, respectively. The results of the in‐vivo toxicity study revealed the absence of noticeable signs of toxicity or mortality at various doses establishing the safety of the tested extract. The estimated LD50 value was higher than 10 g/kg. Antidiabetic action exhibited a noticeable decline in fasting blood glucose (FBG) levels comparable to glibenclamide with no inducing intense hypoglycemia and considerable excess weight.

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Physicochemical characterization, in vitro and in vivo evaluation of chitosan/carrageenan encumbered with Imatinib mesylate-polysarcosine nanoparticles for sustained drug release and enhanced colorectal cancer targeted therapy

Bhattacharya

Bonde

Hatware

et al. 2023

International Journal of Biological Macromolecules

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Toxicity profiling of Burgmansia aurea Lagerh. Leaves using acute and sub-acute toxicity studies in rats

Cited by 7 publications

References 36 publications

Exploring therapeutic potential of Woodfordia fruticosa (L.) Kurz leaf and bark focusing on antioxidant, antithrombotic, antimicrobial, anti‐inflammatory, analgesic, and antidiarrheal properties

Exploring therapeutic potential of Woodfordia fruticosa (L.) Kurz leaf and bark focusing on antioxidant, antithrombotic, antimicrobial, anti‐inflammatory, analgesic, and antidiarrheal properties

Chemical Characterization, Evaluation of Acute Oral Toxicity, and Anti‐Diabetic Activity of Aloe sabaea Flowers Extract on Alloxan‐Induced Diabetic Rats

Physicochemical characterization, in vitro and in vivo evaluation of chitosan/carrageenan encumbered with Imatinib mesylate-polysarcosine nanoparticles for sustained drug release and enhanced colorectal cancer targeted therapy

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