Toxicity of silver nanoparticles in zebrafish models

Asharani, P. V.; Wu, Yi; Gong, Zhiyuan; Valiyaveettil, Suresh

doi:10.1088/0957-4484/19/25/255102

Cited by 918 publications

(594 citation statements)

References 32 publications

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“…In these studies, the particles are typically found to be agglomerated/aggregated, for example, TiO 2 [53,62,65,66], ZnO [43,53,[66][67][68], Ag [23,69], SiO 2 [70], and CeO 2 [53]. Manzo et al [71] analyzed an ZnO NP-contaminated soil by the Brunauer-Emmett-Teller method and found that the particles were not aggregated.…”

Section: Soil Propertiesmentioning

confidence: 99%

Metal‐based nanoparticles in soil: Fate, behavior, and effects on soil invertebrates

Tourinho

Gestel²,

Lofts

et al. 2012

Enviro Toxic and Chemistry

396

229

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Abstract-Metal-based nanoparticles (NPs) (e.g., silver, zinc oxide, titanium dioxide, iron oxide) are being widely used in the nanotechnology industry. Because of the release of particles from NP-containing products, it is likely that NPs will enter the soil compartment, especially through land application of sewage sludge derived from wastewater treatment. This review presents an overview of the literature dealing with the fate and effects of metal-based NPs in soil. In the environment, the characteristics of NPs (e.g., size, shape, surface charge) and soil (e.g., pH, ionic strength, organic matter, and clay content) will affect physical and chemical processes, resulting in NP dissolution, agglomeration, and aggregation. The behavior of NPs in soil will control their mobility and their bioavailability to soil organisms. Consequently, exposure characterization in ecotoxicological studies should obtain as much information as possible about dissolution, agglomeration, and aggregation processes. Comparing existing studies is a challenging task, because no standards exist for toxicity tests with NPs. In many cases, the reporting of associated characterization data is sparse, or missing, making it impossible to interpret and explain observed differences in results among studies. Environ. Toxicol. Chem.

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Section: Soil Propertiesmentioning

confidence: 99%

Metal‐based nanoparticles in soil: Fate, behavior, and effects on soil invertebrates

Tourinho

Gestel²,

Lofts

et al. 2012

Enviro Toxic and Chemistry

396

229

View full text Add to dashboard Cite

show abstract

“…In contrast, surface-enhanced Raman scattering (SERS) technique can amplify Raman signals up to 10 14 folds using metallic surfaces [e.g., silver (Ag) and gold] [6]. The SERS strategy has also demonstrated in vivo Raman measurements with penetration deeper than 700 mm, but the subcutaneous injection of metal nanoparticles can be toxic [7]. Though the use of SERS-active acupuncture needles can eliminate the need of nanoparticle injection [8], these needles are still required to be pulled out from the subject for SERS measurements and skillful needle administration is needed [8,9].…”

Section: Introductionmentioning

confidence: 99%

Towardsin vivointradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe

Yuen

Liu

2013

Journal of Biophotonics

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Journal of BIOPHOTONICSWe propose a microneedle coated with silver (Ag) to detect analytes at low concentrations positioned at a depth of more than 700 mm below the surface of a skin phantom with absorbers and scatterers for mimicking the intradermal surface-enhanced Raman scattering (SERS) measurements. The Ag layer in the Ag-coated microneedle-based probe is found to be the key to the effective detection of analytes buried inside the aforesaid phantom. Glucose concentrations ranging from 5 to 150 mM inside phantoms can be estimated with a root mean square error (RMSE) of 3.3 mM. This work shows the potential of using microneedles for simple in vivo intradermal SERS measurements of analytes with clinical relevance.SERS spectra of R6G molecules positioned inside the bottom layer of an agar phantom at a depth of 760 mm below the surface (inset) measured by using Ag-coated microneedle (conc: 10 -4 M; P EX : 5 mW), microneedle (conc: 10 -2 M; P EX : 5 mW), and ordinary Raman (conc: 10 -2 M; P EX : 100 mW). P EX means the excitation power and conc means concentration of R6G in the bottom layer.

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“…Earlier, PVP stabilized AgNPs were found to upregulate/down-regulate various processes in Chlamydia trachomatis [16]. Various reports on antioxidant system defense, show that oxidative stress is the primary mechanism for toxicity of AgNPs, wherein accumulation of AgNPs in the nucleus is responsible for genomic damage and instability which consequently lead to DNA damage and apoptosis, facilitating mortality [16,17].…”

Section: Amplification Of Antioxidant Bio-marker Enzyme Genesmentioning

confidence: 99%

Effect of biopolymer stabilized silver nanoparticles on antioxidant genes from larvae of Anopheles Stephensi mosquito

Erick¹,

M²,

Maniga³

et al. 2017

Front Nanosci Nanotech

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It is now a fact that silver nano-particles (AgNPs) have many commercial applications wherein AgNPs formulations have exhibited potent insecticidal activity. Our previous research findings demonstrated that the biopolymer stabilized AgNPs cause death at the different developmental stages of A. stephensi. This study was undertaken to examine the toxic effects of biopolymer stabilized AgNPs on various antioxidant gene markers to shade light on mechanism behind death of sanguinivorous insects. The systemic effect analyses on biomarker enzymes and at gene level were characterized after exposure to various biopolymer stabilized AgNPs whereby a concentration of 5 ppm was used based on our previous studies. The AgNPs were shown to up-regulate the total protein levels significantly. The activities of antioxidant enzymes catalase and superoxide dismutase were significantly higher statistically whilst glutathione peroxidase was significantly lower which augmented well to the mRNA level expression profiles. The results indicate that the various biopolymer stabilized AgNPs induce up-regulation of the total protein levels as well as oxidative stress related machineries. These findings suggest that formation of reactive oxygen species via detoxification system may play a role in modulating host defense for the observed larval mortality and thus warrants microarray analyses to reveal the pathways involved for AgNPs formulation as the antioxidant gene responses in A. stephensi are highly diversified, in response to biotic and abiotic stressors. Knowledge on this will not only pave way for novel anti-mosquitol agents but as well offer screening methodology to curb A. stephensi management and incorporated for integrated pest management.

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Toxicity of silver nanoparticles in zebrafish models

Cited by 918 publications

References 32 publications

Metal‐based nanoparticles in soil: Fate, behavior, and effects on soil invertebrates

Metal‐based nanoparticles in soil: Fate, behavior, and effects on soil invertebrates

Towardsin vivointradermal surface enhanced Raman scattering (SERS) measurements: silver coated microneedle based SERS probe

Effect of biopolymer stabilized silver nanoparticles on antioxidant genes from larvae of Anopheles Stephensi mosquito

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