Toxicity of selected airborne nitrophenols on eukaryotic cell membrane models

Majewska, Marta; Khan, Faria; Pieta, Izabela S.; Wróblewska, Aleksandra; Szmigielski, Rafał; Pieta, Piotr

doi:10.1016/j.chemosphere.2020.128996

Cited by 24 publications

(13 citation statements)

References 55 publications

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“…Previous research studies reported that 8-OHdG in cells was related to PM 2.5 as well as its bounded PAHs. , A strong correlation ( R = 0.894, P < 0.05) was observed between PAHs and IL-6 in wintertime samples collected in Taiyuan, China . Majewska et al recently confirmed that cell exposures to high doses of NPs can induce cell membrane damage and reduce cell viability from in vitro cell experiments …”

Section: Results and Discussionmentioning

confidence: 83%

Variations of Personal Exposure to Particulate Nitrated Phenols from Heating Energy Renovation in China: The First Assessment on Associated Toxicological Impacts with Particle Size Distributions

Feng

et al. 2022

Environ. Sci. Technol.

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The clean heating renovation has been executed for improving particulate matter (PM) pollution in northern China since 2017. This study determined particle size distributions of nitrated phenols (NPs) in personal exposure samples and their associations with biomarkers in saliva and urine from homemakers in rural households of the Fenwei Plain, China. Remarkable reductions of 28.6–66.3% and 52.2–82.4% on PMs and total quantified NPs, respectively, were found with the substitutions of raw coal chunk and biomass by advanced clean coal. 4-Nitroguaiacol (4NG) showed the largest reductions of 81.2% among individual NP. In addition, the clean coal efficiently reduced interleukin-6 (IL-6) and 8-hydrox-2′-deoxyguanosine (8-OHdG) in the urine and saliva by 12–72%. Furthermore, significant positive correlations between urinary 8-OHdG with most of NPs in all particle sizes, urinary IL-6 with 4NG for particles with Dp > 2.5 μm and Dp = 0.25–1.0 μm and salivary IL-6 with 4-nitrocatechol and 4-methyl-5-nitrocatechol for particles with Dp > 2.5 μm, Dp = 0.5–1.0 μm, and Dp < 0.25 μm were observed but not for salivary 8-OHdG or PMs. The results provide scientific support for the clean energy reformation and demonstrate the strong particle size dependence between NPs and biomarkers.

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Section: Results and Discussionmentioning

confidence: 83%

Variations of Personal Exposure to Particulate Nitrated Phenols from Heating Energy Renovation in China: The First Assessment on Associated Toxicological Impacts with Particle Size Distributions

Feng

et al. 2022

Environ. Sci. Technol.

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“…We evaluated toxicological profiles of 2NP, 3NP, 4NP, and their equimolar mixture in terms of cytotoxicity, OS, changes in the ΔΨm, and apoptosis. Previously, we showed that lung cell membranes exposed to the equimolar NP mixture (100–200 μg mL −1 ) underwent disruption ( Majewska et al, 2021 ). The IC 50 values of the NPs determined here for two cell lines help estimate the inhalation safety indices.…”

Section: Discussionmentioning

confidence: 99%

“…Equimolar mixtures of 2NP, 3NP, and 4NP caused changes in the eukaryotic cell membrane potential at concentrations above 100 μg mL −1 ( Majewska et al, 2021 ). Electrochemical impedance spectroscopy and atomic force microscopy showed that exposure to NP mixtures profoundly rearranged model eukaryotic cell membrane structures, let NPs internalize, and changed cellular morphology.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and oxidative stress induced by atmospheric mono-nitrophenols in human lung cells

Khan

Jaoui

Rudziński

et al. 2022

Environmental Pollution

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“…Nitrophenol molecules are compounds that have found themselves at the intersection of many fields of science, industry, and chemistry. They are of great interest in environmental chemistry [ 1 , 2 , 3 ], toxicology [ 4 , 5 , 6 ], atmospheric chemistry [ 7 , 8 , 9 , 10 ], chemical and bioengineering [ 2 , 11 ], computational chemistry [ 12 , 13 , 14 ], and ultrafast spectroscopy [ 15 , 16 , 17 , 18 ]. From an environmental perspective, nitrophenols are compact, prototypical examples and building blocks of nitroaromatic compounds, which are used for and produced through a wide variety of industrial applications and are emitted from diesel and gasoline engines.…”

Section: Introductionmentioning

confidence: 99%

Ultrafast Spectroscopies of Nitrophenols and Nitrophenolates in Solution: From Electronic Dynamics and Vibrational Structures to Photochemical and Environmental Implications

2023

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Nitrophenols are a group of small organic molecules with significant environmental implications from the atmosphere to waterways. In this work, we investigate a series of nitrophenols and nitrophenolates, with the contrasting ortho-, meta-, and para-substituted nitro group to the phenolic hydroxy or phenolate oxygen site (2/3/4NP or NP−), implementing a suite of steady-state and time-resolved spectroscopic techniques that include UV/Visible spectroscopy, femtosecond transient absorption (fs-TA) spectroscopy with probe-dependent and global analysis, and femtosecond stimulated Raman spectroscopy (FSRS), aided by quantum calculations. The excitation-dependent (400 and 267 nm) electronic dynamics in water and methanol, for six protonated or deprotonated nitrophenol molecules (three regioisomers in each set), enable a systematic investigation of the excited-state dynamics of these functional “nanomachines” that can undergo nitro-group twisting (as a rotor), excited-state intramolecular or intermolecular proton transfer (donor–acceptor, ESIPT, or ESPT), solvation, and cooling (chromophore) events on molecular timescales. In particular, the meta-substituted compound 3NP or 3NP exhibits the strongest charge-transfer character with FSRS signatures (e.g., C–N peak frequency), and thus, does not favor nitroaromatic twist in the excited state, while the ortho-substituted compound 2NP can undergo ESIPT in water and likely generate nitrous acid (HONO) after 267 nm excitation. The delineated mechanistic insights into the nitro-substituent-location-, protonation-, solvent-, and excitation-wavelength-dependent effects on nitrophenols, in conjunction with the ultraviolet-light-induced degradation of 2NP in water, substantiates an appealing discovery loop to characterize and engineer functional molecules for environmental applications.

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Toxicity of selected airborne nitrophenols on eukaryotic cell membrane models

Cited by 24 publications

References 55 publications

Variations of Personal Exposure to Particulate Nitrated Phenols from Heating Energy Renovation in China: The First Assessment on Associated Toxicological Impacts with Particle Size Distributions

Variations of Personal Exposure to Particulate Nitrated Phenols from Heating Energy Renovation in China: The First Assessment on Associated Toxicological Impacts with Particle Size Distributions

Cytotoxicity and oxidative stress induced by atmospheric mono-nitrophenols in human lung cells

Ultrafast Spectroscopies of Nitrophenols and Nitrophenolates in Solution: From Electronic Dynamics and Vibrational Structures to Photochemical and Environmental Implications

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