Variations of Personal Exposure to Particulate Nitrated Phenols from Heating Energy Renovation in China: The First Assessment on Associated Toxicological Impacts with Particle Size Distributions

Feng, Rong; Xu, Hongmei; Gu, Yan; Wang, Zexuan; Han, Bong-Ho; Sun, Jian; Liu, Suixin; Lu, Hongwei; Ho, Steven Sai Hang; Shen, Zhenxing; Cao, Junji

doi:10.1021/acs.est.1c07950

Cited by 14 publications

(3 citation statements)

References 60 publications

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“…Previous studies have assessed the effects of certain NACs, such as the vasodilatory, estrogenic, and antiandrogenic activities of 4-NP, 2-methyl-4NP, and 3-methyl-4NP by rat thoracic artery and in vitro assays . Eleven NACs in PM 2.5 showed positive correlations with interleukin (IL)-6 and 8-hydrox-2′-deoxyguanosine (8-OHdG) in urine and saliva of 18 homemakers . However, a comprehensive investigation of NACs based on exposure markers is largely absent from the literatures.…”

Section: Resultsmentioning

confidence: 99%

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Exposure Markers of Nitrated Aromatic Compounds and the Association with Nitrative Stress

Lin

Zhu

Chai

et al. 2023

Environ. Sci. Technol. Lett.

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Nitrated aromatic compounds (NACs) belong to a group of ubiquitous environmental contaminants, and lacking exposure markers has restricted the accurate assessment of their exposure and subsequent health effects. Hence, based on gas chromatography and tandem mass spectrometry coupled with an electron capture ion source, we established a novel nontargeted exposomic approach to achieve highly sensitive and standardindependent detection for urinary NACs. Applying this technique to urine samples from a panel of 26 international travelers, we detected 184 NACs, of which 151 were inferred molecular formulas by accurate mass, and 25 were verified by reference standards. The isomeric profiles of the identified NACs suggested their direct excretion without functionalization metabolism after environmental absorption, which was corroborated by in vitro metabolism assays. Levels of 121 NACs, including nitrophenols, hydroxy-nitrobenzoic acids, and nitronaphthols, were increased from 1.3 to 21.1-fold after traveling from Los Angeles to Beijing, in association with ambient NO 2 levels. Most NACs were significantly associated with the marker of nitrative stress, with stronger associations observed in Beijing. This study provided an advanced analytical approach for exposure markers of NACs and preliminary evidence of their potential to trigger nitrative stress, an important but poorly understood response that may relate to adverse health effects.

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Section: Resultsmentioning

confidence: 99%

“…30 Eleven NACs in PM 2.5 showed positive correlations with interleukin (IL)-6 and 8- hydrox-2′-deoxyguanosine (8-OHdG) in urine and saliva of 18 homemakers. 31 However, a comprehensive investigation of NACs based on exposure markers is largely absent from the literatures.…”

Section: Study Design and Sample Collectionmentioning

confidence: 99%

Exposure Markers of Nitrated Aromatic Compounds and the Association with Nitrative Stress

Lin

Zhu

Chai

et al. 2023

Environ. Sci. Technol. Lett.

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“…Further, in the north, the DTTv was closely related to the concentrations of NACs (r of 0.57 to 0.79) (Figure S2), suggesting that NACs could be important contributors to DTT consumption. Feng et al (2022) reported the positive correlations between NACs and biomarkers in saliva and urine (interleukin-6 and 8-hydrox-2ʹ-deoxyguanosine). Zhang et al (2023) also reported that NACs are major proinflammatory components in organic aerosols, contributing about 24% of the interleukin-8 response of all compounds detected by Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) in electrospray ionization negative mode (ESI-).…”

Section: Correlation Between Dtt Activity and Water-soluble Pm25 Comp...mentioning

confidence: 98%

Measurement report: Oxidation potential of water-soluble aerosol components in the southern and northern of Beijing

Yuan,

Huang,

Luo

et al. 2024

Preprint

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Abstract. Water-soluble components have significant contribution to the oxidative potential (OP) of atmospheric fine particles, while our understanding of their relationship is still limited. In this study, the water-soluble OP levels in wintertime PM2.5 in the south and north of Beijing, representing the difference in sources, were measured with dithiothreitol (DTT) assay. The volume normalized DTT (DTTv) in the north (3.5 ± 1.2 nmol min-1 m-3) was comparable to that in the south (3.9 ± 0.9 nmol min-1 m-3), while the mass normalized DTT (DTTm) in the north (65.3 ± 27.6 pmol min-1 μg-3) was almost twice that in the south (36.1 ± 14.5 pmol min-1 μg-3). In both the south and north of Beijing, DTTv was better correlated with soluble elements instead of total elements. In the north, soluble elements (mainly Mn, Co, Ni, Zn, As, Cd and Pb) and water-soluble organic compounds, especially light-absorbing compounds (also known as brown carbon), had positive correlations with DTTv. However, in the south, the DTTv was mainly related to soluble As, Fe and Pb. The sources of DTTv were further resolved using the positive matrix factorization (PMF) model. Traffic-related emissions (39.1 %) and biomass burning (25.2 %) were the main sources of DTTv in the south, and traffic-related emissions (> 50 %) contributed the most of DTTv in the north. Our results indicate that vehicle emission was the important contributor to OP in Beijing ambient PM2.5 and suggest that more study is needed to understand the intrinsic relationship between OP and light absorbing organic compounds.

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Characteristics of PM2.5 and Its Reactive Oxygen Species in Heating Energy Transition and Estimation of Its Impact on the Environment and Health in China—A Case Study in the Fenwei Plain

Wang

Feng

et al. 2023

Adv. Atmos. Sci.

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Variations of Personal Exposure to Particulate Nitrated Phenols from Heating Energy Renovation in China: The First Assessment on Associated Toxicological Impacts with Particle Size Distributions

Cited by 14 publications

References 60 publications

Exposure Markers of Nitrated Aromatic Compounds and the Association with Nitrative Stress

Exposure Markers of Nitrated Aromatic Compounds and the Association with Nitrative Stress

Measurement report: Oxidation potential of water-soluble aerosol components in the southern and northern of Beijing

Characteristics of PM2.5 and Its Reactive Oxygen Species in Heating Energy Transition and Estimation of Its Impact on the Environment and Health in China—A Case Study in the Fenwei Plain

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