Toxicity of Quinolones

Stahlmann, Ralf; Lode, H.

doi:10.2165/00003495-199958002-00007

Cited by 205 publications

(118 citation statements)

References 22 publications

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“…(c) Various dorsal vesicles (V) seem to be associated with plasma membrane rupture (arrowheads), displacement of axonemal microtubules (FA), electron-dense precipitates (P) and empty spaces in cytoplasm (Â48,000) (N, nucleus; AD, adhesive disc; FA, axonemal microtubules; VLF, ventrolateral flange; LC, lateral crest). findings and that CPX had magnesium-chelating properties (Stahlmann and Lode, 1999), our results suggest an interaction of CPX and intracellular Mg 2+ that could be the basis of CPX toxicity.…”

Section: Discussionsupporting

confidence: 52%

The cytotoxic effects of ciprofloxacin in Giardia lamblia trophozoites

Sousa

Poiares-da-Silva

2001

Toxicology in Vitro

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The cytotoxicity of ciprofloxacin was investigated in culture of Giardia lamblia (ATCC 30957), used as an in vitro cellular model, on the basis of cell growth, morphology, viability, adherence and metabolic studies. The effects on cell membrane integrity were evaluated by permeability of the cells to trypan blue, and the morphological alterations were studied by optical and transmission electronic microscopy. The metabolic studies were performed by measured oxygen uptake with a Clark-type oxygen electrode. Our data show that ciprofloxacin induces loss of viability with morphological alterations and loss of membrane integrity. Ultrastructural observations revealed that this drug promoted modifications on the cell shape, pronounced dorsal vesiculation, plasma membrane blebbing, disaggregation of ribosome, coagulation of cytoplasmic matrix, and heavy deposit of electron-dense precipitates on the cytoplasm and nucleus. Ciprofloxacin also inhibits parasite growth, adherence and O 2 uptake in a concentrationdependent manner. Some of these observations suggest that cytotoxicity of ciprofloxacin results in cell death by a necrosis process. We demonstrate that ciprofloxacin has a lethal effect in G. lamblia trophozoites and could be used as an alternative drug in giardiasis treatment, particularly in infections that are resistant to other antibiotics. #

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Section: Discussionsupporting

confidence: 52%

The cytotoxic effects of ciprofloxacin in Giardia lamblia trophozoites

Sousa

Poiares-da-Silva

2001

Toxicology in Vitro

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“…The withdrawal time for marbofloxacin orally administered in broiler chickens was ranged between 3 days at a dose of 2mg/kg BW for 3 days [15] and Yang et al [21] reported 4 days at a dose of 5 mg/kg BW for 3 days that supported our results. The withdrawal period in rabbits was 2 days after S/C injection of marbofloxacin at a dose of 2mg/kg BW for 5 days as reported by Ligabue et al [17].…”

Section: Discussionsupporting

confidence: 88%

“…Drug residues is defined as the very low amounts of drugs remained in animal products [13], that may lead to allergy, antibiotic resistance, disruption of intestinal flora and chronic toxic effects with prolonged administration [14]. Fluoroquinolones have health hazards as they cause gastro-intestinal toxicity, photo irritation and developmental alteration with joints inflammation [15]. High concentrations of marbofloxacin were detected after 24 h from the last administered dose in both kidneys and liver which were much lower than those reported by Anadon et al [16] who mentioned that marbofloxacin concentration in both kidneys and liver were 0.985 and 0.735 µg/gm, respectively in healthy Ross male broiler chickens received marbofloxacin at dose of 2mg/kg BW for 3 days.…”

Section: Discussionmentioning

confidence: 99%

Determination of Marbofloxacin residues in Rabbit Tissues by HPLC

Aziz

El‐Nabtity

Barawy³

et al. 2017

Zagazig Veterinary Journal

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The present study was designed to evaluate marbofloxacin residues in different rabbit tissues after multiple intramuscular administrations. For that purpose, rabbits were divided into two groups; the first group (n=21) administered 2mg/kg marbofloxacin for five successive days, while the second group (n=3) were untreated and served as controls. th and 21 st day after the last dose post administration of the drug. Liver, kidneys, pectoral muscle and thigh muscles, spleen, heart, blood and lung from each rabbit were taken, extracted and marbofloxacin residues were analyzed using high-performance liquid chromatographic method with ultraviolet detection. Results indicated a widespread distribution of marbofloxacin in the most tested tissues. It remained within detectable level till the 5 th day in liver and serum while it continues till the 7 th in kidneys day following the last dose. Therefore, muscles of rabbits treated with marbofloxacin could be consumed safely following the 1 st day post treatment, while liver and kidneys could be consumed safely in the 3 rd day after treatment without any hazards on consumers as the residual level below the recommended MRL (150µg/kg).

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“…The adverse effects of newer fluoroquinolones are dose dependent having steep dose response relationship. 19 The present study was aimed at defining the testicular morphological changes produced by fluoroquinolones such as ciprofloxacin, ofloxacin and enoxacin. No.…”

Section: Introductionmentioning

confidence: 99%