1993
DOI: 10.2131/jts.18.supplementiii_1
|View full text |Cite
|
Sign up to set email alerts
|

Toxicity of Polyoxyethylene Hydrogenated Castor Oil 60 (Hco-60) in Experimental Animals

Abstract: HCO-60, a polyoxyethylene castor oil derivative, is used as a solubilizer in the injectable formulations of lipophilic agents. This study was performed to examine the toxicity of HCO-60 in various experimental animals including dogs, monkeys, rabbits, guinea pigs and rats. With 1.25 or 2.5 mg/kg of HCO-60 injected i.v. to dogs, blood pressure decreased, flush, swelling and itching appeared after injection, and with 10 mg/kg of HCO-60 there was additionally a decrease of spontaneous motility. In the two higher … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
12
0

Year Published

1997
1997
2023
2023

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 14 publications
(13 citation statements)
references
References 5 publications
1
12
0
Order By: Relevance
“…It has been reported that intravenous administration of more than 1.25 mg/kg HCO-60 causes anaphylaxis-like symptoms such as flushes and decrease of blood pressure as a result of histamine release from mast cells in dogs, whereas these effects are not observed in monkeys, rabbits, guinea pigs or rats. 21) These findings are consistent with our current study and previous observations. 8) If caused by additives such as solubilizers, severe anaphylaxis-like symptoms may modulate the PK profile of the main drug and thereby the crossover study must be terminated.…”
Section: Discussionsupporting
confidence: 94%
“…It has been reported that intravenous administration of more than 1.25 mg/kg HCO-60 causes anaphylaxis-like symptoms such as flushes and decrease of blood pressure as a result of histamine release from mast cells in dogs, whereas these effects are not observed in monkeys, rabbits, guinea pigs or rats. 21) These findings are consistent with our current study and previous observations. 8) If caused by additives such as solubilizers, severe anaphylaxis-like symptoms may modulate the PK profile of the main drug and thereby the crossover study must be terminated.…”
Section: Discussionsupporting
confidence: 94%
“…Acute toxicity studies were conducted for PEG-60 hydrogenated castor oil in various animals including male and female Beagle dogs, male and female cynomolgus monkeys, male New Zealand white rabbits, male Hartley guinea pigs, and male S-D rats. Overall results showed systemic and irritant effects only in dogs, and not in the other animals tested, indicating species-specific effects (22) .…”
Section: Peg Compounds For Cosmetic Usementioning
confidence: 76%
“…Anaphylaxis has been reported with IV administration, although it is thought to be due to the castor oil derivative in the injectable formulation [13]. The description of tacrolimus toxicity is confounded by the concomitant use of other immunosuppressants or the co-existence of underlying pathology.…”
Section: Discussionmentioning
confidence: 99%