Toxicity of Polymeric Nanoparticles with Respect to their Application as Drug Carriers

Chervenkov, Trifon; Ivanova, Diana; Galunska, B.; Gerova, Daniela; Yankova, T.

doi:10.1007/978-1-4020-6076-2_7

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…It is important to note that the toxicological effects are also of substantial importance to the potential of novel therapeutic agents. While separate studies have shown nanoparticulate silica and KSL are nontoxic, , the composities presented here will need to undergo extensive toxicological analysis before they are to be considered as therapeutic drugs.…”

Section: Discussionmentioning

confidence: 99%

Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties

2008

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Amphiphilicity and cationicity are properties shared between antimicrobial peptides and proteins that catalyze biomineralization reactions. Merging these two functionalities, we demonstrate a reaction where a cationic antimicrobial peptide catalyzes self-biomineralization within inorganic matrices. The resultant antimicrobial peptide nanoparticles retain biocidal activity, protect the peptide from proteolytic degradation, and facilitate a continuous release of the antibiotic over time. Taken together, these properties demonstrate the therapeutic potential of selfsynthesizing biomaterials that retain the biocidal properties of antimicrobial peptides.

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Section: Discussionmentioning

confidence: 99%

Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties

2008

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“…However, these metallic nanoparticles were previously synthesized using polymers or any other coating materials 33 , 34 . Several reports have indicated the toxicity caused due to the use of polymers in nanoparticle-mediated drug delivery systems 35 – 37 . In the present study, we used the green synthesis method for the production of nanoparticles as it is eco-friendly, less toxic, more stable, and cost-effective (as instead of high energy machines and expensive chemicals, plants are used).…”

Section: Discussionmentioning

confidence: 99%

Magnetofection approach for the transformation of okra using green iron nanoparticles

Farooq

Ather

Shafiq

et al. 2022

Sci Rep

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Climate change, pesticide resistance, and the need for developing new plant varieties have galvanized biotechnologists to find new solutions in order to produce transgenic plants. Over the last decade scientists are working on green metallic nanoparticles to develop DNA delivery systems for plants. In the current study, green Iron nanoparticles were synthesized using leaf extract of Camellia sinensis (green tea) and Iron Chloride (FeCl3), the characterization and Confirmation was done using UV–VIS Spectroscopy, FTIR, SEM, and TEM. Using these nanoparticles, a novel method of gene transformation in okra plants was developed, with a combination of different Magnetofection factors. Maximum gene transformation efficiency was observed at the DNA to Iron-nanoparticles ratio of 1:20, by rotation of mixture (Plasmid DNA, Iron-nanoparticles, and seed embryo) at 800 rpm for 5 h. Using this approach, the transformation of the GFP (green fluorescent protein) gene was successfully carried out in Abelmoschus esculentus (Okra plant). The DNA transformation was confirmed by observing the expression of transgene GFP via Laser Scanning Confocal Microscope (LSCM) and PCR. This method is highly economical, adaptable, genotype independent, eco-friendly, and time-saving as well. We infer that this approach can be a potential solution to combat the yield and immunity challenges of plants against pathogens.

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“…Although inspiring from biological viewpoint, polymeric NPs has also been reported to trigger detrimental responses. Nanopolymers made of silica dioxide have been shown to increase the kidney weight and creatinine levels when given intraperitoneally at 200 mg/kg body weight in in vivo animal model [73]. Another potential challenge for biodegradable polymeric nanoparticles is associated with solvent residues and polymer toxicity.…”

Section: Drug Delivery Systems To Increase Bioavailabilitymentioning

confidence: 99%

Bioavailability of phytochemicals and its enhancement by drug delivery systems

Aqil¹,

Munagala²,

Jeyabalan³

et al. 2013

Cancer Letters

271

163

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Issues of poor oral bioavailability of cancer chemopreventives have hindered progress in cancer prevention. Novel delivery systems that modulate the pharmacokinetics of existing drugs, such as nanoparticles, cyclodextrins, niosomes, liposomes and implants, could be used to enhance the delivery of chemopreventive agents to target sites. The development of new approaches in prevention and treatment of cancer could encompass new delivery systems for approved and newly investigated compounds. In this review, we discuss some of the delivery approaches that have already made an impact by either delivering a drug to target tissue or increasing its bioavailability by many fold.

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Toxicity of Polymeric Nanoparticles with Respect to their Application as Drug Carriers

Cited by 6 publications

References 20 publications

Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties

Synthesis of Bioinorganic Antimicrobial Peptide Nanoparticles with Potential Therapeutic Properties

Magnetofection approach for the transformation of okra using green iron nanoparticles

Bioavailability of phytochemicals and its enhancement by drug delivery systems

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