Toxicity of methylmercury chloride in rats I. Short-term study

Verschuure, H.G.; Kroes, R.; Tonkelaar, Engelina M. den; Berkvens, J.M.; Helleman, P. W.; Rauws, A. G.; Schuller, P. L.; Esch, G.J. van

doi:10.1016/0300-483x(76)90010-x

Cited by 26 publications

(10 citation statements)

References 10 publications

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“…This is consistent with some findings by Ulfvarson (1969), Klein et al (1972), andVerschuuren et al (1976a). Previous studies revealed that rats bind considerably more mercury in the blood than mouse and guinea pig, with higher blood to brain ratios (12-20) of mercury concentration for rats than mice, guinea pigs, dogs, monkeys and humans (Iverson et al, 1973).…”

Section: Discussionsupporting

confidence: 93%

“…A single IP injection of 24 mg MeHg/kg BW induced a significant decrease in hemoglobin, RBC count, and Hct% values in mice after 4 and 14 days of exposure (Shaw et al, 1991). After 12 weeks of dietary exposure, 25 ppm MeHg caused no changes in hemoglobin, Hct%, and RBC and WBC counts, but dramatically increased neutrophil counts and decreased lymphocyte counts in rats (Verschuuren et al, 1976a). However, little is known regarding the interaction of MeHg and diets on hematological parameters.…”

Section: Discussionmentioning

confidence: 95%

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Modulating effects of dietary fats on methylmercury toxicity and distribution in rats

et al. 2007

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Modulating effects of dietary fats on methylmercury toxicity and distribution in rats

et al. 2007

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“…Methyl mercury (MeHg), a compound which is generated from inorganic mercury by environmental microorganisms and which causes, among others, pathological changes in the central nervous system in man (Minamata disease, Tsubaki and Irukayama 1977) and in rats (Verschuuren et al 1976). …”

Section: The Reference Compoundsmentioning

confidence: 99%

Toxicological pathology in laboratory fish: an evaluation with two species and various environmental contaminants

Wester

Vos

1994

Ecotoxicology

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: This paper presents an overview of the studies carried out in small laboratory fish species to investigate the usefulness of histopathology as a tool in aquatic toxicology. The studies were performed with medaka (Oryzias latipes) and guppy (Poecilia reticulata) that were exposed to a variety of environmental contaminants for one and three months. Besides the measurement of routine toxicological parameters, total body histopathology was carried out. The data are summarized and evaluated in view of their contribution to the knowledge of toxicology, the specific responsiveness of animals and tissues, and the application in ecotoxicology. It is concluded that histopathology of (small) fish exposed to environmental contaminants may provide useful information as to target organs and mechanism of action: moreover, this technique can be more sensitive than routine parameters.

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“…In addition, after the 120-day exposure period, the platelet quantity (PLT) was significantly increased (P \ 0.05) in groups AII, BIII, BIV, and CV (Table 4). Effects of MeHg on hematological characteristics have been reported in cats (Charbonneau et al 1974) and rats (Verschuuren 1976a(Verschuuren , 1976b(Verschuuren , 1976cMunro et al 1980). In mice, intraperitoneal injection of methylmercury induced a significant decrease in hemoglobin, RBC count, and HCT % values (Shaw et al 1991).…”

Section: Hematological Parameter Changes Under Hg-polluted Soil Impactmentioning

confidence: 92%

Health effects of ingestion of mercury-polluted urban soil: an animal experiment

Muccillo-Baisch

Mirlean

Carrazzoni

et al. 2011

Environ Geochem Health

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Rio Grande, the southernmost Brazilian port and industrial center, is marked by mercury-polluted ground cover. This pollution varies spatially, with levels exceeding 1,000 μg kg(-1) in 30% of the urban territory. The risk of Hg impact as a result of deliberate and involuntary geophagy is increased by restrained urban conditions in combination with the large proportion of the population living at low-income levels. Laboratory tests have demonstrated that ingestion of Hg-polluted soil by rats results in significant alterations in animal health such as stagnation in body weight increase, and significant mercury accumulation in the liver and kidney. The consumption of Hg-contaminated urban soil also provoked changes in hematological profiles of experimental animals by increasing the number of platelets. The present study indicates the potential for the local population of Rio Grande living in mercury-polluted districts, specifically young children, to experience health disturbances.

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Toxicity of methylmercury chloride in rats I. Short-term study

Cited by 26 publications

References 10 publications

Modulating effects of dietary fats on methylmercury toxicity and distribution in rats

Modulating effects of dietary fats on methylmercury toxicity and distribution in rats

Toxicological pathology in laboratory fish: an evaluation with two species and various environmental contaminants

Health effects of ingestion of mercury-polluted urban soil: an animal experiment

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