Toxicity of hypercaloric diet and monosodium glutamate: oxidative stress and metabolic shifting in hepatic tissue

Diniz, Yeda S.; Fernandes, Ana Angélica Henrique; Campos, Kleber Eduardo de; Mani, Fernanda; Ribas, B.; Novelli, Ethel L. B.

doi:10.1016/j.fct.2003.09.006

Cited by 109 publications

(92 citation statements)

References 36 publications

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“…Moreover, inflammatory leukocyte infiltration, activated Kupffer cells, dilated central vein and blood sinusoids were markedly recorded. These results were accordance with those reported by Diniz et al (2004) who found that administration of MSG was associated with oxidative stress in hepatic tissues, leading to increased glycogen content of liver cells as a result of hyperglycemia and hyperinsulinemia. Malik and Ahluwalia (1994) reported that subcutaneous administration of MSG to adult mice (dose level over 4 mg/g b.wt.)…”

Section: Discussionsupporting

confidence: 83%

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Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

2016

Res. Opin. Anim. Vet. Sci.

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Monosodium glutamate (MSG) is one of the most widely used food additives as a flavour enhancer but its high dose can induce toxic effects on the liver. Melatonin is a potent antioxidant, could ameliorate acute and chronic hepatic injury. The present work was essentially designed to evaluate the ameliorating role of melatonin on the liver of pregnant female Albino rats and their pups induced by MSG. In the present research, twenty four pregnant Albino rats were divided into four groups (n=6). The control group received saline solution, the melatonin group received 100 mg/kg b.wt, MSG treated group received 400 mg/kg b.wt and ameliorative group received MSG 400 mg/kg b.wt simultaneously with melatonin 100 mg/kg b.wt. All groups were received their corresponding dose from the 4 th day of gestation till the end of weaning period. The histological study of the current work revealed that MSG could induce damage of hepatocytes with cytoplasmic vacuolation, dilation of central vein and blood sinusoids, prominent Kupffer cells, infiltration cells around the portal area, variable degree of fibrosis, and scattered fatty cells. Furthermore, MSG consumption is also associated with ultrastructural alterations that varied considerably from mild structural changes to cytoplasmic lysis and degradation of some cellular organelles. Such alterations were represented by undifferentiated cytoplasm with dispersed vacuoles, nuclear pyknosis, swollen and vacuolated mitochondria, manifested dilated rough endoplasmic reticulum, remarkable aggregation of glycogen granules and fat droplets and obvious dispersion of collagenous fibers. Supplementation of melatonin ameliorated MSG-induced histopathological and ultrastrucural changes in liver cells. Keywords: MSG, Liver, Melatonin, Histopathlology, Fibrosis, TEM, HepatocytesTo cite this article: Abd El-Fattah BM El-Beltagy, 2016. Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate. Res. Opin. Anim. Vet. Sci., 6(2): 59-68.

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Section: Discussionsupporting

confidence: 83%

“…body weight). The dose was chosen according to Diniz et al (2004) and Waer and Edress (2006). Group IV: Include six female pregnant rats that were given oral dose of MSG at the rate of 450 mg/kg body weight) simultaneously with I.P dose of melatonin (100 mg/kg body weight).…”

Section: Experimental Groupsmentioning

confidence: 99%

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

2016

Res. Opin. Anim. Vet. Sci.

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“…The supernatant was used for the quantification of phycocyanin by reading in the spectrophotometer at 640 nm and comparing it to a standard curve previously prepared. The dose of monosodium glutamate was given to the rats, intraperitoneally, at a concentration of 4 mg/body g, using references from Diniz et al (2004). The four experimental groups were divided into control group (G 1 ), phycocyanin group (G 2 ), glutamate group (G 3 ) and phycocyanin + glutamate group (G 4 ).…”

Section: Methodsmentioning

confidence: 99%

Antioxidant effect of phycocyanin on oxidative stress induced with monosodium glutamate in rats

Bertolin

Farias

Guarienti

et al. 2011

Braz. arch. biol. technol.

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“…It is reported that excess glutamate causes overstimulation in the brain, prolongs migraine attacks, and causes neuronal death due to overstimulation. It has been linked to diseases such as obesity (Dolnikoff et al 2001), type 2 diabetes (Nagata et al 2006), and neurotoxicity (Singh et al 2003;Park et al 2000), primarily affecting the liver Diniz et al 2004;Egbuonu et al 2009;Elagouza et al 2010). Since the liver is the central organ of detoxification, it is therefore susceptible to damage through different oxidative processes.…”

Section: Introductionmentioning

confidence: 98%

Preliminary study on the protective effect of vitamin C on monosodium glutamate-induced hepatotoxicity in rats

et al. 2014

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Monosodium glutamate (MSG) is a food additive with a wide range of biological effects but its high dose and prolonged use can cause a toxic effect on the liver. Therefore, the present study was aimed at investigating the role of vitamin C in MSG-induced hepatotoxicity in rats. MSG was administered to rats (by gavage) at a dose of 6 mg/g body weight for 10 days to induce hepatotoxicity, and vitamin C at a dose of 500 mg/kg body weight was coadministered to evaluate its ameliorating effect by measuring alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities in serum; superoxide dismutase (SOD) and catalase activities in liver fraction; lipid peroxidation; and liver weight. It was found that MSG significantly (P<0.05) induced lipid peroxidation (LPO), increased liver weight, and increased activity of SOD and catalase in the liver of animals. The activity of ALT and AST was also increased in the serum on MSG administration. Vitamin C (500 mg/kg) coadministered with MSG significantly reduced LPO and liver weight and decreased the hepatic activity of catalase, but the activity of SOD was not reduced significantly. Also, a significant reduction in ALT and AST activity was observed. MSG induced oxidative stress and hepatic toxicity in the experimental animals at a dose of 6 mg/g body weight. Vitamin C significantly reduced the oxidative stress and hepatic toxicity induced by MSG, thereby providing a protective effect against the MSGinduced hepatotoxicity. The protective effect is associated with decreased LPO and liver weight and decreased activities of catalase, ALT, and AST.

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Toxicity of hypercaloric diet and monosodium glutamate: oxidative stress and metabolic shifting in hepatic tissue

Cited by 109 publications

References 36 publications

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

Ameliorative effects of melatonin on the liver of pregnant albino rats and their offspring induced by monosodium glutamate

Antioxidant effect of phycocyanin on oxidative stress induced with monosodium glutamate in rats

Preliminary study on the protective effect of vitamin C on monosodium glutamate-induced hepatotoxicity in rats

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